A5015614820- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Nutrition, Genetics, and Disease
- Bipolar Disorder and Treatment
- Lipoproteins and Cardiovascular Health
- Functional Brain Connectivity Studies
- Birth, Development, and Health
- Advanced Neuroimaging Techniques and Applications
- Health disparities and outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Epigenetics and DNA Methylation
- Obesity, Physical Activity, Diet
- Diabetes Treatment and Management
- Tryptophan and brain disorders
- Health, Environment, Cognitive Aging
- Cardiovascular Disease and Adiposity
- Sleep and related disorders
- Dementia and Cognitive Impairment Research
- Chronic Disease Management Strategies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Mental Health Treatment and Access
- Muscle activation and electromyography studies
- Adolescent and Pediatric Healthcare
- Nutritional Studies and Diet
- Liver Disease Diagnosis and Treatment
University of Glasgow
2016-2025
Karolinska Institutet
2019-2022
Gartnavel General Hospital
2019
Royal Victoria Infirmary
2007
Collège de France
1993
Abstract Depression is a polygenic trait that causes extensive periods of disability. Previous genetic studies have identified common risk variants which progressively increased in number with increasing sample sizes the respective studies. Here, we conduct genome-wide association study 322,580 UK Biobank participants for three depression-related phenotypes: broad depression, probable major depressive disorder (MDD), and International Classification Diseases (ICD, version 9 or 10)-coded MDD....
Background UK Biobank is a well-characterised cohort of over 500 000 participants including genetics, environmental data and imaging. An online mental health questionnaire was designed for to expand its potential. Aims Describe the development, implementation results this questionnaire. Method expert working group questionnaire, using established measures where possible, consulting patient group. Operational criteria were agreed defining likely disorder risk states, lifetime depression,...
Background UK Biobank is a well-characterised cohort of over 500 000 participants that offers unique opportunities to investigate multiple diseases and risk factors. Aims An online mental health questionnaire completed by was expected expand the potential for research into disorders. Method expert working group designed questionnaire, using established measures where possible, consulting with patient regarding acceptability. Case definitions were defined operational criteria lifetime...
Cannabis use is observationally associated with an increased risk of schizophrenia, but whether the relationship causal not known. Using a genetic approach, we took 10 independent variants previously identified to associate cannabis in 32 330 individuals determine nature association between and schizophrenia. Genetic were employed as instruments recapitulate randomized controlled trial involving two groups (cannabis users vs nonusers) estimate effect on schizophrenia 34 241 cases 45 604...
Chronic pain is highly prevalent worldwide and represents a significant socioeconomic public health burden. Several aspects of chronic pain, for example back severity-related phenotype 'chronic grade', have been shown previously to be complex heritable traits with polygenic component. Additional pain-related phenotypes capturing an individual's overall sensitivity experiencing reporting also suggested as focus investigation. We made use measure the number sites in individuals within UK...
Higher body mass index (BMI) is a risk factor for cardiometabolic disease; however, the underlying causal associations remain unclear.To use UK Biobank data to report estimates of association between BMI and disease outcomes traits, such as pulse rate, using mendelian randomization.Cross-sectional baseline from population-based cohort study including 119 859 participants with complete phenotypic (medical sociodemographic) genetic data. Participants attended 1 22 assessment centers across...
We have employed immunohistochemistry for multiple markers to investigate the structure and possible function of different compartments human cerebral wall from formation cortical plate at 8 postconceptional weeks (PCW) arrival thalamocortical afferents 17 PCW. New observations include subplate emerging as a discrete differentiated layer by 10 PCW, characterized synaptophysin vesicular gamma-aminobutyric acid transporter expression also seen in marginal zone, suggesting that these may...
1. The behaviour of nuclear bag and chain intrafusal fibres in isolated cat muscle spindles with a blood supply, during stimulation dynamic gamma axons, beta or static axons ventral root filaments was observed recorded on still moving film. 2. Most were controlled by one axon (sometimes axon) three which often non-selective distribution. A large majority fusimotor pole the spindle only. 3. Dynamic produced focal contraction only two any this fibre never activated axons. Maximal tetanic...
The association between loneliness and suicide is poorly understood. We investigated how living alone, emotional support were related to self-harm in a longitudinal design.Between 2006 2010 UK Biobank recruited assessed detail over 0.5 million people middle age. Data linked prospective hospital admission mortality records. Adjusted Cox regression models used investigate relationships arrangements, support, both as outcomes.For men, alone (Hazard Ratio (HR) 2.16, 95%CI 1.51-3.09) with...
Reported associations between shiftwork and health have largely been based on occupation-specific, or single sex studies that might not be generalizable to the entire working population. The objective of this study was investigate whether independently associated with obesity, diabetes, poor sleep, well-being in a large, UK general population cohort.Participants Biobank who were employed at time assessment included. Exposure variables self-reported (any night shiftwork); outcomes objectively...
Apolipoprotein (APOE) e4 genotype is an accepted risk factor for accelerated cognitive aging and dementia, though its neurostructural substrates are unclear. The deleterious effects of this on brain structure may increase in magnitude into older age. This study aimed to investigate UK Biobank the association between APOE allele presence vs. absence imaging variables that have been associated with worse abilities; whether varies by cross-sectional We used magnetic resonance (MRI) genetic data...
UK Biobank is a prospective cohort study of around half-a-million general population participants, recruited between 2006 and 2010, with baseline studies at recruitment multiple assessments since. From 2014 to date, magnetic resonance imaging (MRI) has been pursued in participant sub-sample, the aim scan n = 100k. This sub-sample studied widely therefore understanding its relative characteristics important for future reports. We aimed quantify psychological physical health compared rest...
Abstract Mood instability is a core clinical feature of affective and psychotic disorders. In keeping with the Research Domain Criteria approach, it may be useful construct for identifying biology that cuts across psychiatric categories. We aimed to investigate biological validity simple measure mood evaluate its genetic relationship several disorders, including major depressive disorder (MDD), bipolar (BD), schizophrenia, attention deficit hyperactivity (ADHD), anxiety post-traumatic stress...
Anhedonia is a core symptom of several psychiatric disorders but its biological underpinnings are poorly understood. We performed genome-wide association study state anhedonia in 375,275 UK Biobank participants and assessed for genetic correlation between neuropsychiatric conditions (major depressive disorder, schizophrenia, bipolar obsessive compulsive disorder Parkinson's Disease). then used polygenic risk score approach to test loading both brain structure function. This included:...
Objectives To assess whether a history of major depressive disorder (MDD) in middle-aged individuals with hypertension influences first-onset cardiovascular disease outcomes. Design Prospective cohort survival analysis using Cox proportional hazards regression median follow-up 63 months (702 902 person-years). Four mutually exclusive groups were compared: only (n=56 035), MDD (n=15 098), comorbid plus (n=12 929) and an unaffected (no hypertension, no MDD) comparison group (n=50 798). Setting...
Risk-taking behaviour is a key component of several psychiatric disorders and could influence lifestyle choices such as smoking, alcohol use, diet. As phenotype, risk-taking therefore fits within Research Domain Criteria (RDoC) approach, whereby identifying genetic determinants this trait has the potential to improve our understanding across different disorders. Here we report genome-wide association study in 116,255 UK Biobank participants who responded yes/no question "Would you consider...
Abstract Major depression is a debilitating psychiatric illness that typically associated with low mood, anhedonia and range of comorbidities. Depression has heritable component remained difficult to elucidate current sample sizes due the polygenic nature disorder. To maximise size, we meta-analysed data on 807,553 individuals (246,363 cases 561,190 controls) from three largest genome-wide association studies depression. We identified 102 independent variants, 269 genes, 15 gene-sets...
Circadian rhythms are fundamental to health and particularly important for mental wellbeing. Disrupted of rest activity recognised as risk factors major depressive disorder bipolar disorder. We conducted a genome-wide association study (GWAS) low relative amplitude (RA), an objective measure rest-activity cycles derived from the accelerometer data 71,500 UK Biobank participants. Polygenic scores (PRS) RA were used investigate potential associations with psychiatric phenotypes. Two...
the apolipoprotein (APOE) e4 locus is a genetic risk factor for dementia. Carriers of allele may be more vulnerable to conditions that are independent factors cognitive decline, such as cardiometabolic diseases.we tested whether any association with APOE status on ability was larger in older ages or those diseases.UK Biobank includes over 500,000 middle- and aged adults who have undergone detailed medical phenotypic assessment. Around 150,000 currently data. We examined 111,739 participants...