A5022659943- Circadian rhythm and melatonin
- Advanced Chemical Sensor Technologies
- Diet and metabolism studies
- Dietary Effects on Health
- Sleep and related disorders
- Gastrointestinal motility and disorders
- Sleep and Wakefulness Research
- Meat and Animal Product Quality
- Climate Change and Health Impacts
- Heme Oxygenase-1 and Carbon Monoxide
- Spaceflight effects on biology
- Biochemical Analysis and Sensing Techniques
- Neuroscience of respiration and sleep
- Gastroesophageal reflux and treatments
- Obesity, Physical Activity, Diet
- Psychological and Temporal Perspectives Research
- Health, Environment, Cognitive Aging
- High Altitude and Hypoxia
- Thermal Regulation in Medicine
- Olfactory and Sensory Function Studies
- Veterinary Equine Medical Research
- Obesity and Health Practices
- Metabolomics and Mass Spectrometry Studies
- Impact of Light on Environment and Health
- Biochemical effects in animals
National University of Ireland, Maynooth
2022-2024
Royal College of Surgeons in Ireland
2017-2021
University College Dublin
2020
University of Glasgow
2004-2020
University of Aberdeen
2009-2016
Département Santé Animale
2016
Swansea University
2008-2010
University of Bristol
2005-2009
Scottish Enterprise
2007
Scottish Universities Environmental Research Centre
2007
A variety of innate immune responses and functions are dependent on time day, many inflammatory conditions associated with dysfunctional molecular clocks within cells. However, the functional importance these has yet to be fully characterized. NRF2 plays a critical role in system, limiting inflammation via reactive oxygen species (ROS) suppression direct repression proinflammatory cytokines, IL-1β IL-6. Here we reveal that core clock protein, BMAL1, controls mRNA expression Nrf2 E-box...
Methionine restriction (MR) decreases body weight and adiposity improves glucose homeostasis in rodents. Similar to caloric restriction, MR extends lifespan, but is accompanied by increased food intake energy expenditure. Most studies have examined young animals; therefore, the aim of this study was investigate ability reverse age-induced obesity insulin resistance adult animals. Male C57BL/6J mice aged 2 12 months old were fed (0.172% methionine) or control diet (0.86% for 8 weeks 48 h....
Reported associations between shiftwork and health have largely been based on occupation-specific, or single sex studies that might not be generalizable to the entire working population. The objective of this study was investigate whether independently associated with obesity, diabetes, poor sleep, well-being in a large, UK general population cohort.Participants Biobank who were employed at time assessment included. Exposure variables self-reported (any night shiftwork); outcomes objectively...
Seasonal disease outbreaks are perennial features of human infectious but the factors generating these patterns unclear. Here we investigate seasonal and daytime variability in multiple immune parameters 329,261 participants UK Biobank test for associations with a wide range environmental lifestyle factors, including changes day length, outdoor temperature vitamin D at time blood sample was collected. were evident lymphocyte neutrophil counts, C-reactive protein CRP, not monocytes,...
Adaptive immunity in homeotherms depends greatly on CD4+ Th cells which release cytokines response to specific antigen stimulation. Whilst bony fish and poikilothermic tetrapods possess that express TcR CD4-related genes (that exist two forms teleost fish; termed CD4-1 CD4-2), date there is no unequivocal demonstration equivalent exist. Thus, this study we determined whether CD4-1+ lymphocytes can typical of following stimulation, using the zebrafish (Danio rerio). Initially, analyzed CD4...
Circadian rhythms are fundamental to health and particularly important for mental wellbeing. Disrupted of rest activity recognised as risk factors major depressive disorder bipolar disorder. We conducted a genome-wide association study (GWAS) low relative amplitude (RA), an objective measure rest-activity cycles derived from the accelerometer data 71,500 UK Biobank participants. Polygenic scores (PRS) RA were used investigate potential associations with psychiatric phenotypes. Two...
Biological rhythms that oscillate with periods close to 24 h (circadian cycles) are pervasive features of mammalian physiology, facilitating entrainment the cycle generated by rotation Earth. In absence environmental time cues, circadian default their endogenous period called tau , or free-running period. This sustained rhythmicity in constant conditions has been reported across animal kingdom, a ubiquity could imply innate confers an adaptive advantage. this study, we found deviation from...
The Earth's solar orbit induces annual climatic changes challenging to survival. Many animals have evolved cope with seasonal variability through compensatory in their physiology and behavior, which involve innate long-term timing photoperiodic synchronization anticipate the environmental cycles. Here we considered potential involvement of cyclical histogenesis mechanisms sheep. Adult Soay rams were established three distinctive states by controlled photoperiod exposure. A first group,...
In this paper, we present a radiotelemetry sensor, designed as lab-in-a-pill, which incorporates two-channel microfabricated sensor platform for real-time measurements of temperature and pH. These two parameters have potential application use in remote biological sensing (for example they may be used markers that reflect the physiological environment or indicators disease, within gastrointestinal tract). We investigated effects biofouling on these sensors, by exploring their response time...
Abstract Background The prevalence of sleep disturbance is high and increasing. study investigated whether active, former passive smoking were associated with disturbance. Methods This cross-sectional used data from the UK Biobank: a cohort 502 655 participants, whom 498 208 provided self-reported on characteristics. Multivariable multinomial logistic regression models to examine associations between Results Long-sleep duration (>9 h) was more common among current smokers [odds ratio...
The assessment of belief that equine conformation is associated with performance and durability a fundamental concept horsemanship. Surprisingly, there almost no quantitative evidence to support these beliefs.To assess the prevalence heritability conformational traits in Thoroughbred yearlings, investigate their significance for subsequent turf flat-racing durability.Nine selected were assessed consistent, qualitative manner by single veterinary observer entered into database together...