A5035391535- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Optical Coherence Tomography Applications
- Ophthalmology and Eye Disorders
- Retinal and Optic Conditions
- Retinal Development and Disorders
- Cerebral Venous Sinus Thrombosis
- Ocular Surface and Contact Lens
- Intraocular Surgery and Lenses
- Optical Imaging and Spectroscopy Techniques
- Ophthalmology and Visual Impairment Studies
- Retinal and Macular Surgery
- Genetic Associations and Epidemiology
- Neurological Disorders and Treatments
- Corneal Surgery and Treatments
- Retinopathy of Prematurity Studies
- Air Quality and Health Impacts
- Traumatic Brain Injury and Neurovascular Disturbances
- Photoacoustic and Ultrasonic Imaging
- Spectroscopy Techniques in Biomedical and Chemical Research
- Elasticity and Material Modeling
- Blood Pressure and Hypertension Studies
- Traffic and Road Safety
University College London
2016-2025
Moorfields Eye Hospital NHS Foundation Trust
2016-2025
Moorfields Eye Hospital
2014-2024
The University of Sydney
2015-2024
UK Biobank
2021-2023
Queen's University Belfast
2023
National Institute for Health Research
2008-2022
Singapore Eye Research Institute
2012-2020
National Health Service
2008-2020
Singapore National Eye Center
2013-2020
Primary open angle glaucoma and ocular hypertension are habitually treated with eye drops that lower intraocular pressure. Selective laser trabeculoplasty is a safe alternative but rarely used as first-line treatment. We compared the two.In this observer-masked, randomised controlled trial treatment-naive patients or no comorbidities were recruited between 2012 2014 at six UK hospitals. They randomly allocated (web-based randomisation) to initial selective drops. An objective target pressure...
Abstract Medical artificial intelligence (AI) offers great potential for recognizing signs of health conditions in retinal images and expediting the diagnosis eye diseases systemic disorders 1 . However, development AI models requires substantial annotation are usually task-specific with limited generalizability to different clinical applications 2 Here, we present RETFound, a foundation model that learns generalizable representations from unlabelled provides basis label-efficient adaptation...
To improve the quality of optical coherence tomography (OCT) images optic nerve head (ONH).Two algorithms were developed, one to compensate for light attenuation and other enhance contrast in OCT images. The former was borrowed from developments ultrasound imaging proven suitable with either time- or spectral-domain OCT. latter based on direct application pixel intensity exponentiation. performances these two tested four adult ONHs.Application compensation algorithm significantly reduced...
Given that the neural and connective tissues of optic nerve head (ONH) exhibit complex morphological changes with development progression glaucoma, their simultaneous isolation from optical coherence tomography (OCT) images may be great interest for clinical diagnosis management this pathology. A deep learning algorithm (custom U-NET) was designed trained to segment 6 ONH tissue layers by capturing both local (tissue texture) contextual information (spatial arrangement tissues). The overall...
Identifing potential screening tests for future cognitive decline is a priority developing treatments and the prevention of dementia.To examine retinal nerve fiber layer (RNFL) thickness measurement in identifying those at greater risk large community cohort healthy people.UK Biobank prospective, multicenter, community-based study UK residents aged 40 to 69 years enrollment who underwent baseline optical coherence tomography imaging, physical examination, questionnaire. The pilot phase was...
To compare the effectiveness and safety of MicroShunt versus trabeculectomy in patients with primary open-angle glaucoma (POAG).One-year results from a 2-year, prospective, randomized, multicenter, noninferiority study (NCT01881425) conducted United States Europe.Eligible were aged 40-85 years intraocular pressure (IOP) ≥15 ≤40 mmHg mild-to-severe POAG inadequately controlled on maximum tolerated medical therapy.Patients randomized 3:1 to undergo stand-alone implantation or trabeculectomy,...
Cadaveric studies have shown disease-related neurodegeneration and other morphological abnormalities in the retina of individuals with Parkinson disease (PD); however, it remains unclear whether this can be reliably detected vivo imaging. We investigated inner retinal anatomy, measured using optical coherence tomography (OCT), prevalent PD subsequently assessed association these markers development a prospective research cohort.
To investigate whether longitudinal changes deep within the optic nerve head (ONH) are detectable by spectral domain optical coherence tomography (SDOCT) in experimental glaucoma (EG) and these at onset of Heidelberg Retina Tomography (HRT; Engineering, Heidelberg, Germany)-defined surface topography depression.Longitudinal SDOCT imaging (Spectralis; Engineering) was performed both eyes nine rhesus macaques every 1 to 3 weeks. One eye each underwent trabecular laser-induced IOP elevation....
To examine the detection rates, specificity, and agreement between visual field (VF) progression Heidelberg Retina Tomograph (HRT; Engineering, GmbH, Heidelberg, Germany) rim area (RA) in subjects with ocular hypertension (OHT).One hundred ninety-eight OHT 21 control were examined prospectively (1994-2001) regular Humphrey VF (Carl Zeiss Meditec, Inc., Dublin, CA) HRT testing. Point-wise linear regression (PLR) of sensitivity/time was used to assess progression, using standard three-omitting...
Purpose.: To compare serial optic nerve head (ONH) histology with interpolated B-scans generated from a three-dimensional (3-D) spectral domain (SD)-OCT ONH volume acquired in vivo the same normal monkey eye. Methods.: A 15° SD-OCT was eye, IOP manometrically controlled at 10 mm Hg. After perfusion fixation Hg, trephined, specimen embedded paraffin block, and sagittal sections cut 4-μm intervals. The location of each histologic section identified within disc photograph by matching position...
To investigate spectral domain optical coherence tomography (SD-OCT)-detected optic disc margin anatomy in the monkey eye by colocalizing photographs to SD-OCT scans acquired from same eyes.The neural canal opening (NCO) was delineated within 40 digital radial sections generated volumes 33 normal eyes (15 degrees, 290 x 768 horizontal grid pattern). Each volume colocalized its photograph matching retinal vessels each vessel outlines visible en face images. Border tissue where it extended...
IOP is the most common independent risk factor for development and progression of glaucoma, but very little known about dynamics. Continuous telemetry was used in three nonhuman primates to characterize dynamics at multiple time scales 24-hour periods.An existing implantable telemetric pressure transducer system adapted monitoring anterior chamber IOP. The records 500 IOP, ECG, body temperature measurements per second compensates barometric real time. continuous signal digitally filtered...
Purpose.: To determine whether acutely elevated IOP alters optic nerve head (ONH) structural parameters characterized in vivo using spectral domain optical coherence tomography (SD-OCT). Methods.: Five rhesus macaques were tested under isoflurane anesthesia. SD-OCT images of the ONH both eyes acquired 30 minutes after was stabilized to 10 mm Hg and 60 stabilization 45 Hg. The internal limiting membrane, Bruch's membrane/retinal pigment epithelium, neural canal opening (NCO), anterior lamina...
We improved the visibility of lamina cribrosa (LC), including its posterior boundary, in optical coherence tomography (OCT) images human optic nerve head (ONH).An adaptive compensation algorithm was developed to overcome a limitation our standard algorithm, that is overamplification noise at high depth. Such currently hampers ability distinguish LC boundary. In compensation, operations are performed until an energy threshold reached, which stage process stopped limit deeper portion OCT...
To develop a deep learning approach to digitally stain optical coherence tomography (OCT) images of the optic nerve head (ONH).A horizontal B-scan was acquired through center ONH using OCT (Spectralis) for one eye each 100 subjects (40 healthy and 60 glaucoma). All were enhanced adaptive compensation. A custom network then designed trained with compensated (i.e., highlight) six tissue layers ONH. The accuracy our algorithm assessed (against manual segmentations) dice coefficient,...
Purpose: To measure lamina cribrosa (LC) strains (deformations) following abduction and adduction in healthy subjects to compare them with those resulting from a relatively high acute intraocular pressure (IOP) elevation. Methods: A total of 16 eyes 8 were included. Among the eyes, 11 had peripapillary atrophy (PPA). For each subject, both optic nerve heads (ONHs) imaged using optical coherence tomography (OCT) at baseline (twice), different gaze positions (adduction 20°) an IOP elevation...
To compare the visibility of lamina cribrosa (LC) in optic disc images acquired from 60 glaucoma and control subjects using three optical coherence tomography (OCT) devices, with without enhanced depth imaging (EDI) adaptive compensation (AC).A horizontal B-scan was through center two spectral-domain (Spectralis Cirrus; EDI) a swept-source (DRI) OCT. Adaptive applied post acquisition to improve image quality. assess LC visibility, four masked observers graded 1200 randomized sequence. The...
PurposeTo report clinical efficacy, predictors of success, and safety primary selective laser trabeculoplasty (SLT) used in treatment-naive patients with open-angle glaucoma (OAG) or ocular hypertension (OHT).DesignPost hoc analysis a multicenter, prospective, randomized, controlled trial.ParticipantsTreatment-naive OAG OHT.MethodsPatients randomized to SLT topical medication treated predefined target intraocular pressures (IOPs) requiring ≥20% IOP reduction from baseline for all disease...
Purpose: Glaucoma is more common in urban populations than others. Ninety percent of the world's population are exposed to air pollution above World Health Organization (WHO) recommended limits. Few studies have examined association between and glaucoma. Methods: Questionnaire data, ophthalmic measures, ambient residential area quality data for 111,370 UK Biobank participants were analyzed. Particulate matter with an aerodynamic diameter < 2.5 μm (PM2.5) was selected as exposure interest....