A5048854546- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Ophthalmology and Eye Disorders
- Retinal Development and Disorders
- Ocular Diseases and Behçet’s Syndrome
- Plant responses to water stress
- Nuts composition and effects
- Plant and Fungal Interactions Research
- Plant nutrient uptake and metabolism
- Legume Nitrogen Fixing Symbiosis
- Visual perception and processing mechanisms
- Corneal surgery and disorders
- Functional Brain Connectivity Studies
- Cerebral Venous Sinus Thrombosis
- Ophthalmology and Visual Impairment Studies
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Sleep and related disorders
- Blood properties and coagulation
- Sleep and Wakefulness Research
- Gout, Hyperuricemia, Uric Acid
- Biochemical and Molecular Research
Xihua University
2024
Tan Tock Seng Hospital
2016-2024
Affiliated Hospital of Nantong University
2024
Nantong University
2024
National University of Singapore
2013-2024
Central South University
2011-2023
Second Xiangya Hospital of Central South University
2011-2023
Hunan Provincial Center for Disease Control and Prevention
2019-2021
National Eye Institute
2021
Khoo Teck Puat Hospital
2018-2019
To evaluate choroidal structural changes in exudative age-related macular degeneration (AMD) using vascularity index computed from image binarization on spectral domain optical coherence tomography with enhanced depth imaging.This prospective case series included 42 consecutive patients unilateral AMD. Choroidal images were segmented into luminal area and stromal area. was defined as the ratio of to total choroid Mean mean thickness between study fellow eyes same patient dry AMD compared...
Abstract Purpose Recently, choroidal vascularity index ( CVI ) is proposed as a novel tool to evaluate the vasculature. In this study, we investigate impact of scanning area on measurement using spectral‐domain optical coherence tomography SD ‐ OCT ). Methods Spectral‐domain (SD‐OCT) enhanced depth imaging mode was performed in 30 eyes from 15 normal subjects. Three areas were compared: dingle foveal scan; central macular scans [scan passing through 1000 microns circle Early Treatment...
To compare the visibility of lamina cribrosa (LC) in optic disc images acquired from 60 glaucoma and control subjects using three optical coherence tomography (OCT) devices, with without enhanced depth imaging (EDI) adaptive compensation (AC).A horizontal B-scan was through center two spectral-domain (Spectralis Cirrus; EDI) a swept-source (DRI) OCT. Adaptive applied post acquisition to improve image quality. assess LC visibility, four masked observers graded 1200 randomized sequence. The...
Accurate diagnosis and timely management are vital for favorable uveitis outcomes. Artificial Intelligence (AI) holds promise in medical decision-making, particularly ophthalmology. Yet, the diagnostic precision advice from AI-based chatbots lack assessment.
The purpose of this study was to investigate the cytokine profiles in plasma and aqueous humor patients with choroidal neovascularization (CNV) due exudative AMD polypoidal vasculopathy (PCV).In cross-sectional study, 16 clinically diagnosed AMD, 18 PCV, 50 age- sex-matched cataract without AMD/PCV (controls) were enrolled. Study subjects treatment naïve, 200 μL undiluted 5 mL peripheral venous blood collected from subjects. Clinical samples analyzed for 41 different cytokines by Luminex...
Purpose: Cigarette smoking is a known risk factor for vascular dysfunction. This study evaluated choroidal structural changes in smokers using the vascularity index (CVI) derived from image binarization on spectral domain optical coherence tomography scans with enhanced depth imaging (EDI-OCT). Methods: cross-sectional included 39 and 44 non-smokers. Choroidal images EDI-OCT were binarized into luminal area (LA) stromal (LA). CVI was calculated as ratio of LA to total choroid (TCA). CVI,...
Purpose: To compare the agreement between optical coherence tomography (OCT)-based choroidal vascularity markers measured by two previously reported image binarization techniques. Methods: Spectral-domain OCT using enhanced-depth imaging was performed in 100 eyes from 52 normal subjects. Choroidal images were binarized to luminal area and stromal different algorithms. marker defined as ratio of total they termed “luminal/choroidal (L/C ratio)” “choroidal index (CVI)” per algorithm. The...
To assess choroidal structural changes in patients with retinal dystrophies using vascularity index (CVI), a novel optical coherence tomography (OCT) based tool.This retrospective study included 26 (17 retinitis pigmentosa, four Stargardt disease, three cone-rod dystrophy, one each Best disease and Bietti crystalline dystrophy) 32 healthy controls. Subfoveal OCT images were used for analysis. Mean CVI was compared between dystrophy control group, as well among the subgroups.Mean eyes 52 ± 9%...
Objective. This study is aimed at investigating differences in local brain activity and functional connectivity (FC) between children with unilateral amblyopia healthy controls (HCs) by using resting state magnetic resonance imaging (rs-fMRI). Methods. Local FC analysis methods were used to explore the altered spontaneous of amblyopia. function included amplitude low-frequency fluctuation (ALFF). consisted primary visual cortex (PVC-FC) other regions network interest (ROIs-FC) selected...
Urban greenways (UGW) are increasingly recognized as vital components of urban green infrastructure (UGI). While existing research has provided empirical evidence on the positive impacts UGW physical health, studies focusing effects mental health remain limited. Moreover, previous investigations predominantly compare a whole with other built environments, neglecting influence specific vegetation designs along health. To address this gap, we conducted randomized controlled experiment to...
Three susceptibility loci for primary angle-closure glaucoma (PACG) were recently identified: PLEKHA7 rs11024102, COL11A1 rs3753841, and rs1015213 located in the intergenic region between PCMTD1 ST18. The purpose of this study was to investigate associations these with ocular biometric parameters anterior chamber depth (ACD) axial length (AL).Genotype data available four population-based studies, including three from Singapore (Singapore Chinese Eye Study, Malay Indian Study) one China...
Stargardt disease (STGD) is the most common hereditary macular degeneration in juveniles, with loss of central vision occurring first or second decade life. The aim this study to identify genetic defects 33 probands disease. Clinical data and genomic DNA were collected from unrelated families STGD. Variants coding genes initially screened by whole exome sequencing. Candidate variants selected all known associated retinal dystrophy then confirmed Sanger Putative pathogenic further validated...
Purpose: To analyze choroidal angioarchitecture in sympathetic ophthalmia (SO) using swept-source optical coherence tomography (SS-OCT) images.Methods: Case-control study of six patients with SO. Qualitative changes and quantitative parameters, including thickness (CT) vascularity index (CVI), were analyzed.Results: findings the acute phase SO on SS-OCT included retinal serous detachment hyperreflective septa, folds, alterations loss vascular lacunae, Dalen-Fuchs nodules. There was...
Recently, three genetic susceptibility loci for primary angle closure glaucoma (PACG) were identified: COL11A1 rs3753841, PCMTD1-ST18 rs1015213, and PLEKHA7 rs11024102. The purpose of this study was to investigate whether these single nucleotide polymorphisms (SNPs) affect the phenotype PACG patients.A retrospective analysis performed 700 Singaporean Chinese patients who had been genotyped. associations between SNPs clinical features related severity studied. For a subgroup ≥ 5 years...