Quan Dong Nguyen
A5102022309- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Ocular Infections and Treatments
- Infectious Diseases and Tuberculosis
- Retinal Diseases and Treatments
- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Intraocular Surgery and Lenses
- Sarcoidosis and Beryllium Toxicity Research
- Retinal and Macular Surgery
- Antifungal resistance and susceptibility
- Optical Coherence Tomography Applications
- Photoacoustic and Ultrasonic Imaging
- Retinal Imaging and Analysis
- Toxoplasma gondii Research Studies
- Cytomegalovirus and herpesvirus research
- Glaucoma and retinal disorders
- Vitamin D Research Studies
- Cancer-related molecular mechanisms research
- Travel-related health issues
- Leprosy Research and Treatment
- Otitis Media and Relapsing Polychondritis
- Neurological and metabolic disorders
- Retinal Development and Disorders
- Ocular Oncology and Treatments
Smith-Kettlewell Eye Research Institute
2017-2025
Stanford University
2017-2025
QIMR Berghofer Medical Research Institute
2024
The University of Queensland
2024
Memorial Hospital
2023
Stanford Medicine
2020
Neurosciences Institute
2020
San Francisco Foundation
2018
Advanced Imaging Research (United States)
2016-2017
Johns Hopkins University
2002-2016
Sadiq, Mohammad A.; Loh, Graeme K.; Sepah, Yasir J.; Nguyen, Quan Dong; Lin, PhoebeEditor(s): McDonald, H. Richard Author Information
Eradication of systemic tuberculosis (TB) has been limited by neglected populations and the HIV pandemic. Whereas ocular TB often presents as uveitis without any prior evidence TB, existing uncertainty in diagnosis may perpetuate missed opportunities to address TB.To examine clinical features associations with response antitubercular therapy (ATT).This retrospective multinational cohort study included patients from 25 ophthalmology referral centers diagnosed treated ATT January 1, 2004,...
Accurate diagnosis and timely management are vital for favorable uveitis outcomes. Artificial Intelligence (AI) holds promise in medical decision-making, particularly ophthalmology. Yet, the diagnostic precision advice from AI-based chatbots lack assessment.
Purpose: To standardize a nomenclature system for defining clinical phenotypes, and outcome measures reporting research data in patients with ocular tuberculosis (OTB).Methods: Uveitis experts initially administered further deliberated the survey an open meeting to determine propose preferred terms related OTB, describing phenotypes treatment outcomes.Results: The group of reached consensus on terming uveitis attributable (TB) as tubercular uveitis. working introduced SUN-compatible that...
Purpose: To analyze the role of polymerase chain reaction (PCR) ocular fluids in management tubercular (TB) anterior, intermediate, posterior, and panuveitis.Methods: In Collaborative Ocular Tuberculosis Study (COTS)-1 (25 centers, n = 962), patients with TB-related uveitis were included. 59 undergoing PCR intraocular (18 females; 53 Asian Indians) included.Results: (6.13%) COTS-1 underwent analysis. was positive for Mycobacterium TB 33 (23 males; all Indians). 26 negative males). Eight had...
To assess the ability of enhanced depth imaging optical coherence tomography (EDI-OCT) in detecting variations structure and size choroidal granulomas response to treatment compare these findings with indocyanine green angiography (ICGA).EDI-OCT ICGA images eyes patients diagnosed tubercular or sarcoid uveitis were obtained at baseline follow-up visits. Two independent masked observers analyzed lesions changes their structural features such as shape, reflectivity, margins, among others,...
Purpose: To contribute a global description of the spectrum choroidal involvement in tubercular uveitis (TBU).Methods: Retrospective cohort study TBU patients with from 25 centers between January 2004 and December 2014. Medical records minimum follow-up 1 year were reviewed.Results: 245 included. The phenotypic variations included serpiginous-like choroiditis (SLC) (46%), tuberculoma (13.5%), multifocal (MFC) (9.4%), ampiginous (9%), among others. 219 treated anti-tubercular therapy (ATT) (n...
Purpose: The aim of this study was to examine regional variation management practices and outcomes for tubercular uveitis (TBU). Methods: In retrospective multinational cohort study, patients from 25 international eye care centers diagnosed with TBU a minimum follow-up 1 year were included. geographic in treatment on survival analysis analyzed. Treatment failure is defined as persistence or recurrence inflammation within 6 months completing antitubercular therapy, the inability taper oral...
To detect choriocapillaris changes by enhanced depth imaging optical coherence tomography (EDI-OCT) in areas of hypoperfusion visualized on indocyanine green angiography.Combined angiography and EDI-OCT from patients diagnosed with inflammatory were retrospectively analyzed. The EDI-OCTs compared to suggestive both active stage (AS) inactive the disease. was graded two independent observers for pattern (normal/altered) reflectivity (hyper/hypo/isoreflective) changes. Manual measurements...
Abstract Purpose To report IgG4-related ophthalmic disease (IgG4-ROD) presenting as posterior scleritis in a pediatric patient. Observations A 7-year-old girl presented with proptosis, painful eyelid swelling, and restricted extraocular movements (EOM) of her left eye (OS). Visual acuity (VA) was 20/20 right (OD) counting fingers (CF) at 1 foot OS. Slit lamp examination revealed 2 + anterior chamber (AC) cells, optic disc edema (ODE) elevated appearance macula Optical coherence tomography...
Purpose: Tubercular retinal vasculitis (TRV) is a heterogeneous disease that can be difficult to manage because of nonspecific presentation and limitations confirmatory tests for tuberculosis. This big data analysis on phenotypes treatment outcomes TRV. Methods: Multicentre retrospective study patients with TRV between January 2004 December 2014 minimum follow-up 1 year. Results: Two hundred fifty-one mean age 38.9 ± 14.4 years (range, 9–86 years) were included. The predominantly males (n =...
Noninfectious uveitis is a leading cause of visual impairment with an unmet need for additional treatment options.
We introduce a new multi aperture system capable of capturing six identical images the human fundus at different spectral bands. The is based on lenslet array architecture and well suited for spectroscopy application. multi-aperture was interfaced with camera to acquire spectroscopic sensitive retina vessel ultimately calculate oxygen saturation in vivo. In vitro testing showed that able accurately reconstruct curves partially oxygenated hemoglobin. vivo healthy volunteers conducted yielded...
Background: Tuberculosis (TB) is a major infection that can affect the eye as first and sole presentation without features of systemic disease. Controversy exists regarding diagnosis management tubercular uveitis (TBU), further compounded by regional variations in disease expression. Purpose: Collaborative Ocular Study (COTS)-1 aims to address knowledge deficits through collaboration amongst specialists across globe sharing data patients with TBU presented at participating centers from...
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Abstract Importance In a subset of patients with retinal vasculitis, there is occlusion blood flow through the vessels. These eyes are at high risk sight‐threatening complications. Background To characterize epidemiology, clinical course, treatment and outcomes occlusive vasculitis (ORV). Design Retrospective study Participants Seventy‐seven uveitis ORV two large tertiary‐care institutions (the USA India). Methods Out 2438 screened, 346 were diagnosed which 77 (96 eyes) ORV. Patients...
Long non-coding RNAs (lncRNAs) play pivotal roles in gene regulation and disease, including cancer. Overcoming the limitations of lncRNA analysis with bulk data, we analyzed single-cell spatial transcriptomics data to uncover 354937 novel lncRNAs their functions across 13 cancer types. LncRNA were assessed by identifying cell-type specificity distinct distributions different tissue regions. First, computationally validated comparing existing databases, experimentally using long read...