A5030893283- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Systemic Lupus Erythematosus Research
- Ocular Infections and Treatments
- Intraocular Surgery and Lenses
- Toxoplasma gondii Research Studies
- Sarcoidosis and Beryllium Toxicity Research
- Vasculitis and related conditions
- Herpesvirus Infections and Treatments
- Bartonella species infections research
- Ophthalmology and Visual Impairment Studies
- Cerebral Venous Sinus Thrombosis
- Syphilis Diagnosis and Treatment
- Corneal surgery and disorders
- Rabies epidemiology and control
- Cytomegalovirus and herpesvirus research
- Traumatic Ocular and Foreign Body Injuries
- Retinal Imaging and Analysis
- Retinal and Macular Surgery
- Drug-Induced Ocular Toxicity
- Antibiotic Resistance in Bacteria
- Ophthalmology and Eye Disorders
- Yersinia bacterium, plague, ectoparasites research
Université Paris Cité
2016-2025
Hôpital Cochin
2016-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Sorbonne Paris Cité
2014-2025
Maternité Port Royal
2004-2023
Inserm
1997-2021
Centre de Recherche des Cordeliers
2020-2021
Physiopathologie et Epidémiologie des Maladies Respiratoires
2020
Hôpital Broca
2020
Délégation Paris 5
2010-2019
Patients with noninfectious uveitis are at risk for long-term complications of uncontrolled inflammation, as well the adverse effects glucocorticoid therapy. We conducted a trial to assess efficacy and safety adalimumab glucocorticoid-sparing agent treatment uveitis.This multinational phase 3 involved adults who had active intermediate uveitis, posterior or panuveitis despite having received prednisone 2 more weeks. Investigators patients were unaware study-group assignments. randomly...
An international, expert-led consensus initiative to develop systematic, evidence-based recommendations for the treatment of noninfectious uveitis in era biologics.The availability biologic agents human eye disease has altered practice patterns management uveitis. Current guidelines are insufficient assure optimal use noncorticosteroid systemic immunomodulatory agents.An international expert steering committee comprising 9 specialists (including both ophthalmologists and rheumatologists)...
To evaluate safety and efficacy of adalimumab in patients with noninfectious intermediate, posterior, or panuveitis.Phase 3, open-label, multicenter clinical trial extension (VISUAL III).Adults meeting treatment failure (TF) criteria who completed VISUAL I II (phase randomized, double-masked, placebo-controlled) without TF.Patients received 40 mg every other week. Interim follow-up data were described from III weeks 0 through 78.Disease quiescence, steroid-free active inflammatory...
When immunocompetent people become infected with the parasite Toxoplasma gondii, disease is generally asymptomatic. However, transplacental transmission of T. gondii may lead to severe congenital infection including in utero abortion, foetal death, or neurological ocular damage foetus. France has had a national programme prevent toxoplasmosis since 1978. although estimated seroprevalence pregnant women fallen from 84% 1960s 44% 2003, no reliable data have been available on annual number...
The recent outbreak of coronavirus disease 2019 (COVID-19) has been declared a public health emergency worldwide. scientific community put in much effort and published studies that described COVID-19’s biology, transmission, clinical diagnosis, candidate therapeutics, vaccines. However, to date, only few data are available on the impact COVID-19 pandemic ophthalmological care different systems, its future consequences terms disability, access sight-saving cures for many patients. To reduce...
Ocular toxoplasmosis is a major cause of posterior uveitis worldwide. The diagnosis based mainly on ophthalmological examination. Biological necessary in atypical cases, and this requires aqueous humor sampling by anterior chamber paracentesis. We evaluated real-time PCR targeting the Toxoplasma gondii 529-bp repeat element, Goldmann-Witmer coefficient (GWC), immunoblotting for toxoplasmic retinochoroiditis 54 patients with uveitis. results these biological tests, applied to paired...
AbstractPURPOSE The aim of this study was to compare the incidence Nd : YAG laser capsulotomy after cataract surgery according type intra-ocular lens material (PMMA, silicone, hydrophilic acrylic, hydrophobic acrylic) implanted in four European countries (France, Italy, Germany, Spain). DESIGN A retrospective record review. PARTICIPANTS review 1525 patients (first operated eye), aged 50 80 years, on for 1996 or 1997 16 surgical centers (4 per country). METHODS employed a cohort design....
To report two cases of acute posterior multifocal placoid pigment epitheliopathy after immunization with a recombinant hepatitis B virus vaccine.Case reports.Two patients had development visual loss 3 days to 2 weeks the booster administration 20 micrograms surface antigen (Engerix-B). In both cases, fundus examination, fluorescein angiograms, and course disease were typical epitheliopathy. case 1, 1 week immunization, leukocyte count was 10.3 X 10(9)/L 24% polynuclear eosinophils (2.47...
<h3>Importance</h3> This case series highlights the risk of uveitis in patients treated with vemurafenib for unresectable or metastatic cutaneous melanoma. <h3>Objective</h3> To assess occurrence and severity as an adverse effect therapy. <h3>Design, Setting, Patients</h3> In this observational small series, data were collected successively from May 1, 2012, through February 31, 2013, clinical signs ocular inflammation at Department Ophthalmology, Cochin-Hôtel-Dieu Hospital. <h3>Main...