A5086343964- Nutrition and Health in Aging
- Frailty in Older Adults
- Maternal and fetal healthcare
- Sports injuries and prevention
- Balance, Gait, and Falls Prevention
- Blood transfusion and management
- Sports Performance and Training
- Diet and metabolism studies
- Exercise and Physiological Responses
- Cancer survivorship and care
- Diabetic Foot Ulcer Assessment and Management
- Maternal and Perinatal Health Interventions
- Metabolomics and Mass Spectrometry Studies
- Chronic Disease Management Strategies
- Cerebral Palsy and Movement Disorders
- Forensic Toxicology and Drug Analysis
- Muscle activation and electromyography studies
- Psychedelics and Drug Studies
- Dementia and Cognitive Impairment Research
- Pregnancy and preeclampsia studies
- Blood donation and transfusion practices
- Muscle metabolism and nutrition
- Cardiovascular and exercise physiology
- Intraocular Surgery and Lenses
- Diabetes Management and Research
Polyclinique de Bordeaux-Tondu
2012-2023
Centre Hospitalier Universitaire de Bordeaux
2012-2023
Université de Bordeaux
2013-2023
Hôpital Xavier Arnozan
2021
French Clinical Research Infrastructure Network
2021
Institut de Neurobiologie de la Méditerranée
2004-2011
Université Savoie Mont Blanc
2009-2011
Aix-Marseille Université
2004-2011
Complexité, Innovation et Activités Motrices et Sportives
2008
Nantes Université
2007
Prophylactic administration of tranexamic acid has been associated with reduced postpartum blood loss after cesarean delivery in several small trials, but evidence its benefit this clinical context remains inconclusive.
Type 2 diabetes, a highly prevalent chronic disease, is associated with increasing frailty and functional decline in older people. We aimed to evaluate the effectiveness of multimodal intervention on performance frail pre-frail participants aged ≥70 years type diabetes mellitus.The MID-Frail study was cluster-randomized multicenter clinical trial conducted 74 sites across seven European countries. The recruited 964 who were >70 [mean age group, 78.4 (SD 5.6) years, 49.2% male 77.6 5.29)...
Abstract Background Older adults with cancer experience negative long‐term functional effects of both and treatments. Exercise may minimize their age‐related cancer‐related decline. Methods We conducted a multicentre open‐label 12 month randomized clinical trial two parallel arms including participants aged ≥70 years lymphoma or carcinoma requiring curative treatment. The study started at the beginning any phase treatment (surgery, chemotherapy, radiotherapy). usual care group (UCG) received...
Diabetes and frailty are highly prevalent conditions that impact the health status of older adults. Perturbations in protein/amino acid metabolism associated with both functional impairment type 2 diabetes mellitus (T2DM). In present study, we compared concentrations a panel circulating 37 amino acids derivatives between frail/pre-frail adults T2DM robust non-diabetic controls. Sixty-six functionally impaired persons aged 70+ 30 age sex-matched controls were included analysis. We applied...
An altered amino acid metabolism has been described in frail older adults which may contribute to muscle loss and functional decline associated with frailty. In the present investigation, we compared circulating profiles of physical frailty sarcopenia (PF&S, n = 94), frail/pre-frail type 2 diabetes mellitus (F-T2DM, 66), robust non-diabetic controls (n 40). Partial least squares discriminant analysis (PLS-DA) models were built define signatures different phenotypes. PLS-DA allowed correct...
Using thermal-based energy sources [radiofrequency (RF) energy/cryo energy] for catheter ablation is considered effective and safe when performing pulmonary vein isolation (PVI) in patients with paroxysmal atrial fibrillation (AF). However, treatment success remains limited complications can occur due to the propagation of thermal into non-target tissues. We aim compare pulsed field (PFA) RF terms efficacy safety drug-resistant AF. The BEAT PAROX-AF trial a European multicentre, superiority,...
Importance The efficacy and safety of femtosecond laser–assisted cataract surgery is well documented. An important requirement for decision makers the evaluation cost-effectiveness (FLACS) over a sufficiently long horizon. Evaluating this treatment was preplanned secondary objective Economic Evaluation Femtosecond Laser Assisted Cataract Surgery (FEMCAT) trial. Objective To estimate cost utility FLACS compared with phacoemulsification (PCS) on 12-month time Design, Setting, Participants This...
COVID-19 pandemic seems to be under control. However, despite the vaccines, 5 10% of patients with mild disease develop moderate critical forms potential lethal evolution. In addition assess lung infection spread, chest CT helps detect complications. Developing a prediction model identify at-risk worsening from combining simple clinical and biological parameters qualitative or quantitative data using would relevant organizing optimal patient management.Four French hospitals were used for...
Minor cross‐over effects of unilateral muscle fatigue have been reported after isometric exercises. The present study re‐examined this possibility an exhaustive stretch‐shortening cycle (SSC)‐type exercise. Twenty‐five subjects performed on a sledge apparatus rebound exercise involving mostly the triceps surae group. Ipsilateral vs contralateral were compared in uni‐ and bilateral tests that included maximal voluntary contraction (MVC) series 10 drop jumps (DJ). These carried out just before...
In this study, we examined the effects of three recovery intensities on time spent at a high percentage maximal oxygen uptake (t90[Vdot]O(2max)) during short intermittent session. Eight endurance-trained male adolescents (16 +/- 1 years) performed four field tests until exhaustion: graded test to determine ([Vdot]O(2max); 57.4 6.1 ml x min(-1) . kg(-1)) and aerobic velocity (17.9 0.4 km h(-1)), exercises consisting repeat 30-s runs 105% alternating with 30 s active 50% (IE(50)), 67%...
( N Engl J Med . 2021;384:1623–1634. doi: 10.1056/NEJMoa2028788. PMID: 33913639) As postpartum hemorrhage (PPH) is a common and potentially deadly complication worldwide, mitigating reducing the risk of PPH critical. Tranexamic acid (TXA) has recently been given to reduce blood loss as it reduces breakdown clots in body slows bleeding, decreasing adverse outcomes mortality hemorrhaging women. Smaller studies have suggested that prophylactic administration TXA following cesarean delivery,...
Importance The stereotype that men perform surgery better than women is ancient. Surgeons have long been mainly men, but in recent decades an inversion has begun; the number of surgeons increasing, especially obstetrics and gynecology. Studies outside suggest postoperative morbidity mortality may be lower after by women. Objective To evaluate association between surgeons’ gender risks maternal postpartum hemorrhage (PPH) cesarean deliveries. Design, Setting, Participants This prospective...
Background & aimsSeveral studies with diabetes-specific formulas (DSFs) for hyperglycaemic patients in need of nutritional support have been conducted non-malnourished patients, mainly comparing products varying macronutrient compositions. Here, the effect a high energy, protein DSF on postprandial responses was compared to product similar composition malnourished or at risk malnutrition type 2 diabetes.MethodsIn this randomised, double-blind cross-over study, 20 were included. After...
The application of a stochastic mechanical noise has been shown to improve plantar touch sensitivity in patients with diabetic neuropathy and balance control. present work aimed test the feasibility specially designed vibrating device on gait posture older type 2 diabetes special interest potential side effect (sensation needles or tingling, dizziness falls) before further investigations. For this, tests were performed 29 out in-patients (mean age 84 years, Barthel index ≥ 60/100)...
Depression symptoms and lower health-related quality of life (HRQoL) are associated with inflammation. This multicenter dietary intervention was shown to reduce inflammation in older people. the main outcome. Here, we describe effects on HRQoL, anxiety, depressive according status. Overall, 125 healthy subjects (65–80 year) were recruited (Italy, France, Germany) randomized into four arms (A, Healthy diet (HD); B, HD plus De Simone Formulation probiotic blend; C, AISA d-Limonene; D, Argan...