A5055987612- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Intraocular Surgery and Lenses
- Corneal surgery and disorders
- Ocular Surface and Contact Lens
- Retinal Imaging and Analysis
- Pelvic floor disorders treatments
- Retinal and Optic Conditions
- Gastroesophageal reflux and treatments
- Gastrointestinal motility and disorders
- Religion, Society, and Development
- Retinal and Macular Surgery
- Ocular Infections and Treatments
- Anorectal Disease Treatments and Outcomes
- South African History and Culture
- Christian Theology and Mission
- Ophthalmology and Eye Disorders
- Retinal Development and Disorders
- Cerebral Venous Sinus Thrombosis
- Clinical Nutrition and Gastroenterology
- Diet and metabolism studies
- African history and culture studies
- Eosinophilic Esophagitis
- Esophageal and GI Pathology
University of KwaZulu-Natal
2015-2025
Hôpital de la Croix-Rousse
2015-2024
Centre de Recherche en Nutrition Humaine d'Auvergne
2014-2024
Unité de Nutrition Humaine
2012-2024
Hospices Civils de Lyon
2015-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2012-2024
Université Claude Bernard Lyon 1
2014-2024
Université Clermont Auvergne
2013-2022
Université du Québec à Montréal
2022
Inserm
1988-2021
PURPOSE: Preliminary studies have shown improvement in fecal incontinence several patients who received temporary or permanent stimulation. The purpose of this study was to report our experience sacral nerve stimulation the treatment and target would benefit most from METHODS: Patients with were studied clinically manometrically before, during, after If successful, patient implanted followed up for six months. RESULTS: Nine (6 female) a mean age 50.7 ± 12.3 years underwent Temporary...
This study was done to understand the different available methods used calculate colorectal transit times. A single abdominal radiograph is taken following six successive daily ingestions of same number identical radiopaque markers. method correlates well (P< 0.001) with that using a ingestion markers x-ray films until total expulsion. In techniques measure time multiple markers, days depends on kinetics marker defecation. found differ markedly in various groups control subjects and...
In addition to rods and cones, the human retina contains light-sensitive ganglion cells that express melanopsin, a photopigment with signal transduction mechanisms similar of invertebrate rhabdomeric photopigments (IRP). Like fly rhodopsins, melanopsin acts as dual-state photosensitive flip-flop in which light drives both phototransduction responses chromophore photoregeneration bestows independence from retinoid cycle required by cones regenerate photoresponsiveness following bleaching...
To evaluate the relative safety and potential efficacy of high-intensity focused ultrasound cyclocoagulation by a miniaturized annular device containing six piezoceramic transducers in patients with refractory glaucoma.This was three-center prospective interventional pilot study. Twelve eyes 12 glaucoma were insonified using ring-shaped probe high-frequency operating at 21 MHz. Ultrasound biomicroscopy (UBM) complete ophthalmic examination performed before procedure 1 day, week, month, 3...
The deterioration of sleep in the older population is a prevalent feature that contributes to decrease quality life. Inappropriate entrainment circadian clock by light considered contribute alteration structure and rhythms elderly. present study investigates effects aging on non-visual spectral sensitivity tests hypothesis disturbances are related decreased transmittance. In within-subject design, eight aged five young subjects were exposed at night 60 minute monochromatic stimulations 9...
Purpose. To determine the prevalence of ocular surface diseases and identify risk factors in a population patients receiving antiglaucomatous eyedrops over long term. Methods. An observational cross-sectional study was designed to investigate signs symptoms using simple clinical tools. disease intensity score calculated based on 10 questions regarding with 4-grade scale. Patients were classified into 3 groups (A, B, C) according this total score. A multinomial logistic regression performed...
To evaluate the efficacy and safety of intravitreal implant dexamethasone (Ozurdex) in diabetic macular edema real-life practice.In this bicentric retrospective study, authors reviewed 128 eyes 89 patients. Main outcome measures included changes best-corrected visual acuity, central thickness, time to retreatment, incidence adverse effects. Linear mixed-effects models were used study acuity thickness over 3-year follow-up.Best-corrected increased by a mean 3.6 letters at Month 2 (P = 0.005),...
To evaluate eubacterial PCR compared with conventional cultures for detection and identification of bacterial agents in ocular samples from patients acute postcataract endophthalmitis.Broad-range amplification was used, followed by direct DNA sequencing (aqueous humor, vitreous tap or vitrectomy) 100 consecutive presenting endophthalmitis. Bacterial were performed on the same using traditional methods (brain-heart infusion broth).At time admission, rate not significantly different between...
Glaucoma is a widespread ocular disease and major cause of blindness characterized by progressive, irreversible damage the optic nerve. Although degenerative loss retinal ganglion cells (RGC) visual deficits associated with glaucoma have been extensively studied, we hypothesize that will also lead to alteration circadian timing system. Circadian non-visual responses light are mediated specialized subset melanopsin expressing RGCs provide photic input mammalian endogenous clock in...
Purpose: To evaluate known and potential risk factors, including nutritional, lifestyle environmental differentiating patients with high-tension primary open-angle glaucoma (POAG) from control subjects ocular hypertension (OHT). Methods: In 2006–2007, 111 French ophthalmologists prospectively enrolled 339 cases of POAG age-matched controls OHT. After a clinical examination assessment the ophthalmologist filled, during face-to-face interview, detailed questionnaire developed by nutritionists...
Purpose.: To evaluate the histologic effects and clinical outcomes of high-intensity focused ultrasound (HIFU) delivered by miniaturized annular transducers for ciliary body coagulation in an animal study. Methods.: Eighteen eyes 18 rabbits were insonified with a ring comprising six-sector transducer, to produce 12.8-mm-diameter circular lesion. Six sectors activated six (group 1), five 2), four 3) at 2 W acoustic power. The examined before treatment (day 0) after on days 1, 7, 15, 21, 28....
Purpose.: To evaluate the safety and efficacy of high-intensity focused ultrasound (HIFU) cyclocoagulation in reducing intraocular pressure (IOP) patients with refractory glaucoma by using a novel miniaturized delivery device (EyeOP1). Methods.: We conducted 12-month open-label multicenter prospective study (EyeMUST1 Study). Patients primary (primary open-angle [POAG]) or secondary were treated two groups depending on duration each shot (group 1: 4 seconds; group 2: 6 seconds). The outcome...
Abstract Purpose To evaluate the efficacy and safety of ultrasonic circular cyclocoagulation procedure in patients with open‐angle glaucoma naïve previous filtering surgery. Methods Prospective non‐comparative interventional clinical study conducted five French University Hospitals. Thirty eyes 30 glaucoma, intra‐ocular pressure (IOP) > 21 mmHg no surgeries were sonicated a probe comprising six piezoelectric transducers. The transducers activated 6‐s exposure time. Complete ophthalmic...
Skeletal muscle mitochondrial function is the biggest component of whole-body energy output. Mitochondrial production during exercise impaired in vitamin D-deficient subjects. In cultured myotubes, loss D receptor (VDR) decreases respiration rate and ATP from oxidative phosphorylation. We aimed to examine effects deficiency supplementation on expenditure old rats, mice, human To gain further insight into mechanisms involved, we used C2C12 cells transgenic mice with muscle-specific VDR...
Abstract TRUEFAD (TRUE Fiber Atrophy Distinction) is a bioimagery user-friendly tool developed to allow consistent and automatic measurement of myotube diameter in vitro, muscle fiber size type using rodents human biopsies. This package was set up standardize dynamize research via easy-to-obtain images run on an open-source plugin for FIJI. We showed here both the robustness performance our pipelines correctly segment cells fibers. evaluated pipeline real experiment image sets reliability...
Objective To evaluate the outcome of artificial anal sphincter implantation for severe fecal incontinence in 37 consecutive patients operated on a single institution from 1993 through 2001. Summary Background Data Implantation an is proposed when local treatment unsuitable or has failed. The results this technique have not been determined yet, and its place among various operative procedures still debated. Methods Artificial sphincters were implanted All had complete failed to respond...
The aim of this multicentre inquiry was to evaluate the prevalence sexual abuse among IBS patients consulting a gastroenterologist, in comparison healthy controls and with organic digestive diseases.Patients irritable bowel syndrome (IBS; Rome Criteria) were included by eight university hospitals (n = 196; 41.2 +/- 20.6 years; sex ratio (M/F) 0.23). Control groups were: (i) for follow-up non-neoplastic diseases 135; 41.5 17.0 1.21); (ii) attending ophthalmology units 200; 43.8 20.7 0.81);...