A5061520379- Circadian rhythm and melatonin
- Photoreceptor and optogenetics research
- Retinal Development and Disorders
- Sleep and Wakefulness Research
- Light effects on plants
- Glaucoma and retinal disorders
- Spaceflight effects on biology
- Genetics, Aging, and Longevity in Model Organisms
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Adipose Tissue and Metabolism
- Nicotinic Acetylcholine Receptors Study
- Psychedelics and Drug Studies
- Neuroendocrine regulation and behavior
- Dietary Effects on Health
- melanin and skin pigmentation
- Parkinson's Disease Mechanisms and Treatments
- Tryptophan and brain disorders
- Chemical synthesis and alkaloids
- Memory and Neural Mechanisms
- Neurobiology and Insect Physiology Research
- Birth, Development, and Health
- Neurological disorders and treatments
- Impact of Light on Environment and Health
Université Claude Bernard Lyon 1
2016-2025
Inserm
2016-2025
Institut Cellule Souche et Cerveau
2016-2025
Centre National de la Recherche Scientifique
2023
Lyon College
2013
Délégation Régionale Auvergne-Rhône-Alpes
2008
Institut de la Vision
2000-2006
Groupe Lépine (France)
2002
Laboratoire d’Ethologie Expérimentale et Comparée
1993-1996
Daily transcription cycling in the baboon Much of our knowledge about important effects circadian rhythms physiology comes from studies mice, which are nocturnal. Mure et al. report transcriptional profiles many tissues and brain regions baboons over a 24-hour period (see Perspective by Millius Ueda). The results emphasize how extensive rhythmic expression is, with more than 80% protein-coding genes involved. They also highlight unanticipated differences between mouse transcripts various...
Recent evidence has emerged that peroxisome proliferator-activated receptor alpha (PPARalpha), which is largely involved in lipid metabolism, can play an important role connecting circadian biology and metabolism. In the present study, we investigated mechanisms by PPARalpha influences pacemakers acting central clock located suprachiasmatic nucleus peripheral oscillator of liver. We demonstrate plays a specific control because it required to maintain rhythm master gene brain muscle Arnt-like...
Glaucoma is a widespread ocular disease and major cause of blindness characterized by progressive, irreversible damage the optic nerve. Although degenerative loss retinal ganglion cells (RGC) visual deficits associated with glaucoma have been extensively studied, we hypothesize that will also lead to alteration circadian timing system. Circadian non-visual responses light are mediated specialized subset melanopsin expressing RGCs provide photic input mammalian endogenous clock in...
Disturbances of the daily sleep/wake cycle are common non-motor symptoms Parkinson's disease (PD). However, impact dopamine (DA) depletion on circadian rhythms in PD patients or non-human primate (NHP) models disorder have not been investigated. We evaluated alterations NHP following MPTP lesion dopaminergic nigro-striatal system. DA degeneration was assessed by vivo PET ([(11)C]-PE2I) and post-mortem TH DAT quantification. In a light∶dark cycle, control MPTP-treated both exhibit rest-wake...
Abstract Strepsirrhines are of considerable interest for understanding the evolution cone photoreceptors because they represent most ancestral living primates. The retina nocturnal is reported to contain a single population medium/long wavelength (MW/LW) cones whereas short (SW) totally absent. area centralis also lacks degree central specialization seen in fovea diurnal In this study Strepsirrhine, gray mouse lemur ( Microcebus murinus ), we used specific antibodies that recognize SW and...
Although deep brain stimulation (DBS) shows promising efficacy as a therapy for intractable depression, the neurobiological bases underlying its therapeutic action remain largely unknown. The present study was aimed at characterizing effects of infralimbic prefrontal cortex (IL-PFC) DBS on several pre-clinical markers antidepressant-like response and investigating putative non-neuronal mechanism action. We found that induced an prevented by IL-PFC neuronal lesion adenosine A1 receptor...
Abstract Background Recent clinical trials reveal that serotonergic psychedelics, including the prototypical hallucinogen lysergic acid diethylamide (LSD), present a promising potential for treating psychiatric disorders, treatment-resistant depression. LSD is potent 5-HT receptors ligand endowed with high affinity most of all subtypes and regularly used as valuable pharmacological tool to characterize 5-HT1A 5-HT2A receptor mediations [1]. Notably, crystal structure in complex human 5-HT2B...
ABSTRACT Ubiquitin‐specific peptidase 2 (USP2) is a deubiquitinase (DUB) with diversity of functions in physiology. One these the regulation circadian rhythms, which are physiological rhythms period ~24 h. Previous studies have indicated role for USP2 photic entrainment, process by clocks synchronize to environmental light cues. Here, we investigated implication this process, using Usp2 knockout (KO) mice. Using different treatments and running wheel recordings, established that controls...
The daily behavioral, physiological, and hormonal rhythms in mammals are regulated by an endogenous circadian clock located the suprachiasmatic nucleus (SCN) synchronized natural 24 hr light/dark cycle. We studied response properties (threshold, saturation, linearity) of photic system to irradiance assaying light induction Fos, protein product immediate early gene c-fos. Fos expression was quantified image analysis SCN retina. retina unrelated because differs terms threshold, range. In SCN,...
While rods, cones, and intrinsically photosensitive melanopsin-containing ganglion cells (ipRGCs) all drive light entrainment of the master circadian pacemaker suprachiasmatic nucleus, recent studies have proposed that mouse retinal clock is exclusively mediated by a UV-sensitive photopigment, neuropsin (OPN5). Here, we report can be phase shifted short duration relatively low-irradiance monochromatic in visible part spectrum, up to 520 nm. Phase shifts exhibit classical photon dose-response...
Chronobiology investigations have revealed much about cellular and physiological clockworks but we are far from having a complete mechanistic understanding of the ecological implications. Here present some unresolved questions in circadian biology research as posed by editorial staff guest contributors to Journal Circadian Rhythms. This collection ideas is not meant be comprehensive does reveal breadth our observations on emerging trends chronobiology biology. It amazing what could achieved...
The induction of the proto-oncogene c-fos, and its phosphoprotein product Fos, has been extensively used to study effects light on circadian pacemaker in suprachiasmatic nucleus (SCN). Experimental approaches quantification Fos have mainly based immunohistochemistry subsequent measure immunoreactivity (IR) sections SCN. In this study, authors compare several methods using optical density image analysis or counts Fos-IR labeled cells. To assess whether measures reflect amount brain tissue,...
Since poor circadian synchrony and cognitive dysfunction have been linked to affective disorders, antidepressants that target key 5-HT (serotonin) receptor subtypes involved in rhythm regulation may therapeutic utility. Vortioxetine is a multimodal antidepressant inhibits 5-HT1D, 5-HT3, 5-HT7 activity, reuptake, enhances the activity of 5-HT1A 5-HT1B receptors. In this study, we investigated effects vortioxetine on period length PER2::LUC expression, behavior, episodic memory, using tissue...
There is increasing evidence that melanopsin-expressing ganglion cells (ipRGCs) are altered in retinal pathologies. Using a streptozotocin-induced (STZ) model of diabetes, we investigated the impact diabetic retinopathy on non-visual functions by analyzing ipRGCs morphology and light-induced c-Fos Period 1–2 clock genes central (SCN). The ability STZ-diabetic mice to entrain light was challenged exposure animals 1) successive light/dark (LD) cycle decreasing or intensities during phase 2)...
The mammalian retina contains an autonomous circadian clock that controls various aspects of retinal physiology and function, including dopamine (DA) release by amacrine cells. This neurotransmitter plays a critical role in development, visual signalling, phase resetting the adulthood. Interestingly, bidirectional regulation between dopaminergic cells melanopsin-expressing ganglion has been demonstrated adult during development. Additionally, melanopsin knockout mouse (Opn4 -/-) exhibits...
Melanopsin, expressed in a subset of intrinsically photosensitive ganglion cells that project to the suprachiasmatic nucleus (SCN), is involved photic entrainment circadian rhythms and other non-image-forming functions (pupil light reflex, masking, acute heart rate response, alertness). Melanopsin has recently been shown be "bireactive" photopigment as photosensory opsin using 11-cis retinaldehyde chromophore intrinsic photoisomerase activity. widely distributed retina vertebrates and,...