A5063888519- Retinal Development and Disorders
- Alzheimer's disease research and treatments
- Photoreceptor and optogenetics research
- Circadian rhythm and melatonin
- Nerve injury and regeneration
- RNA Research and Splicing
- Nuclear Structure and Function
- Neuroinflammation and Neurodegeneration Mechanisms
- Glaucoma and retinal disorders
- Neurological Disease Mechanisms and Treatments
- Retinal Diseases and Treatments
- Cellular Mechanics and Interactions
Université de Strasbourg
2019-2022
Institut des Neurosciences Cellulaires et Intégratives
2019-2022
Centre National pour la Recherche Scientifique et Technique (CNRST)
2020
Centre National de la Recherche Scientifique
2019
Italian Institute of Technology
2013-2016
The architecture and structural mechanics of the cell nucleus are defined by nuclear lamina, which is formed A- B-type lamins. Recently, gene duplication protein overexpression lamin B1 (LB1) have been reported in pedigrees with autosomal dominant leukodystrophy (ADLD). However, how LB1 affects function it may result pathology remain unexplored. Here, we report that primary human skin fibroblasts derived from ADLD patients, LB1, but not other lamins, overexpressed at lamina specifically...
Tauopathies are neurodegenerative diseases characterized by intraneuronal inclusions of hyperphosphorylated tau protein and abnormal expression brain-derived neurotrophic factor (BDNF), a key modulator neuronal survival function. The severity both these pathological hallmarks correlate with the degree cognitive impairment in patients. However, how pathology specifically modifies BDNF signaling affects function during early prodromal stages tauopathy remains unclear. Here, we report that mild...
While rods, cones, and intrinsically photosensitive melanopsin-containing ganglion cells (ipRGCs) all drive light entrainment of the master circadian pacemaker suprachiasmatic nucleus, recent studies have proposed that mouse retinal clock is exclusively mediated by a UV-sensitive photopigment, neuropsin (OPN5). Here, we report can be phase shifted short duration relatively low-irradiance monochromatic in visible part spectrum, up to 520 nm. Phase shifts exhibit classical photon dose-response...
Retinal photoreceptor outer segments (POS) are renewed daily through phagocytosis by the adjacent retinal pigment epithelial (RPE) monolayer. Phagocytosis is mainly driven RPE circadian clock but underlying molecular mechanisms remain elusive. Using ARPE-19 (human cell-line) dispersed and monolayer cell cultures, we investigated influence of cellular organization on genes. PCR analysis revealed rhythmic expression genes in all cultures. Monolayers had a tendency for higher amplitudes gene...
Abstract The circadian system is a hierarchical network of cell and tissue-specific oscillators synchronized to the environmental light/dark cycle. Entrainment mediated by retina through diverse photosensitive cells pigments. itself complex whose cellular constitutive elements have not been fully characterized. By using Nrl -/- cone gain-of-function mouse model we here show that retinal comprises an autonomous oscillator harbored in cones. We further provide novel evidence for input from...
Intracellular inclusions made of microtubule-associated tau protein are a defining pathological hallmark tauopathies, which include Alzheimer disease and familial frontotemporal dementia parkinsonism linked to chromosome 17. Altered levels have been detected in the retina optic nerve patients with glaucoma, suggesting that degeneration tauopathies share similar pathogenic mechanisms. We recently demonstrated P301S mutant human (tauP301S) mice develop filamentous axonopathy retinal ganglion...
Neurotrophins, and especially BDNF, are important modulators of neuronal survival function in the brain visual system. Altered levels TrkB receptors result degeneration proteins associated with extracellular amyloid plaques intraneuronal inclusions made microtubule-associated protein tau Alzheimer disease (AD) brain. AD-type pathological changes have also been reported degenerative diseases retina. For instance, altered detected retina optic nerve patients glaucoma, suggesting that share...
Intracellular inclusions made of microtubule-associated tau protein are a defining pathological hallmark tauopathies, which include Alzheimer disease and familial frontotemporal dementia parkinsonism linked to chromosome 17. Altered levels have been detected in the retina optic nerve patients with glaucoma, suggesting that degeneration tauopathies share similar pathogenic mechanisms. We recently demonstrated P301S mutant human mice (tau P301S) develop filamentous axonopathy retinal ganglion...