A5056051697- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Retinal Development and Disorders
- Circadian rhythm and melatonin
- Photoreceptor and optogenetics research
- Renal and related cancers
- Testicular diseases and treatments
- Epigenetics and DNA Methylation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Musicians’ Health and Performance
- Sexual Differentiation and Disorders
- Porphyrin Metabolism and Disorders
- Neonatal Health and Biochemistry
- Cancer Risks and Factors
- Growth Hormone and Insulin-like Growth Factors
- Pluripotent Stem Cells Research
- Oral and Craniofacial Lesions
- Neuroinflammation and Neurodegeneration Mechanisms
- Endometriosis Research and Treatment
- bioluminescence and chemiluminescence research
- EFL/ESL Teaching and Learning
- Connective tissue disorders research
- Neuroscience of respiration and sleep
- French Language Learning Methods
- Genetics and Neurodevelopmental Disorders
Université de Strasbourg
2014-2025
Inserm
2022-2025
Institut des Neurosciences Cellulaires et Intégratives
2014-2024
Université de Rouen Normandie
2022-2023
Université de Caen Normandie
2023
Normandie Université
2023
University of California, Los Angeles
2023
National Eye Institute
2018-2022
National Institutes of Health
2018-2022
Centre National pour la Recherche Scientifique et Technique (CNRST)
2020
Chromatin organization and enhancer-promoter contacts establish unique spatiotemporal gene expression patterns in distinct cell types. Non-coding genetic variants can influence cellular phenotypes by modifying higher-order transcriptional hubs consequently expression. To elucidate genomic regulation human retina, we mapped chromatin at high resolution integrated with super-enhancers (SEs), histone marks, binding of CTCF select transcription factors. We show that topologically associated...
In mammals, maternal photoperiodic programming (MPP) provides a means whereby juvenile development can be matched to forthcoming seasonal environmental conditions.
In wild mammals, offspring development must anticipate forthcoming metabolic demands and opportunities. Within species, different developmental strategies may be used, dependent on when in the year conception takes place. This phenotypic flexibility is initiated before birth linked to pattern of day length (photoperiod) exposure experienced by mother during pregnancy. programming depends transplacental communication via pineal hormone melatonin. Here, we show that, Siberian hamster (Phodopus...
Rhythmic physiology is central to retinal function and survival adapts vision daily light intensity changes. Mammalian retina rhythmically releases melatonin when cultured under constant conditions, the occurrence of clock gene [e.g., Period(Per)] expression has been shown for most cellular layers. However, contribution distinct layers genesis circadian rhythms within still debated. To characterize their endogenous oscillatory capacity communication at whole-tissue level, we used a...
Aging-associated functional decline is accompanied by alterations in the epigenome. To explore DNA modifications that could influence visual function with age, we perform whole-genome bisulfite sequencing of purified mouse rod photoreceptors at four ages and identify 2,054 differentially methylated regions (DMRs). We detect many DMRs during early stages aging regulatory regions, some these cluster chromosomal hotspots, especially on chromosome 10, which includes a longevity interactome....
Children undergoing cancer treatments are at risk for impaired fertility. Cryopreserved prepubertal testicular biopsies could theoretically be later matured in vitro to produce spermatozoa assisted reproductive technology. A complete spermatogenesis has been obtained from mouse tissue, although with low efficiency. Steroid hormones essential the progression of spermatogenesis, aim this study was investigate steroidogenesis and steroid signaling organotypic cultures. Histological, RT-qPCR,...
Abstract The circadian system is a hierarchical network of cell and tissue-specific oscillators synchronized to the environmental light/dark cycle. Entrainment mediated by retina through diverse photosensitive cells pigments. itself complex whose cellular constitutive elements have not been fully characterized. By using Nrl -/- cone gain-of-function mouse model we here show that retinal comprises an autonomous oscillator harbored in cones. We further provide novel evidence for input from...
Children undergoing cancer treatments are at risk for impaired fertility. Cryopreserved prepubertal testicular biopsies could theoretically be later matured in vitro to produce spermatozoa assisted reproductive technology. A complete spermatogenesis has been obtained from mouse tissue, although with low efficiency. Steroid hormones essential the progression of spermatogenesis, aim this study was investigate steroidogenesis and steroid signaling organotypic cultures. Histological, RT-qPCR,...
Cancer treatments such as chemotherapy can have gonadotoxic effects. In order to preserve and restore the fertility of prepubertal patients with cancer, testicular biopsies are frozen could theoretically be later matured in vitro produce spermatozoa for assisted reproductive technology. A complete spermatogenesis has been obtained from tissue mouse model, although sperm yield was low. Since steroid hormones play an essential role spermatogenesis, it appears necessary ensure that their...
Children undergoing cancer treatments are at risk for impaired fertility. Cryopreserved prepubertal testicular biopsies could theoretically be later matured in vitro to produce spermatozoa assisted reproductive technology. A complete spermatogenesis has been obtained from mouse tissue, although with low efficiency. Steroid hormones being essential the progression of spermatogenesis, aim this study was investigate steroidogenesis and steroid signaling organotypic cultures. Histological,...
Children undergoing cancer treatments are at risk for impaired fertility. Cryopreserved prepubertal testicular biopsies could theoretically be later matured in vitro to produce spermatozoa assisted reproductive technology. A complete spermatogenesis has been obtained from mouse tissue, although with low efficiency. Steroid hormones being essential the progression of spermatogenesis, aim this study was investigate steroidogenesis and steroid signaling organotypic cultures. Histological,...