A5039876698- Circadian rhythm and melatonin
- Diet and metabolism studies
- Bat Biology and Ecology Studies
- Spaceflight effects on biology
- Dermatology and Skin Diseases
- Physiological and biochemical adaptations
- Adipose Tissue and Metabolism
- Light effects on plants
- Molecular Biology Techniques and Applications
- Neuroscience of respiration and sleep
- Genetics, Aging, and Longevity in Model Organisms
- Photoreceptor and optogenetics research
- Asthma and respiratory diseases
- RNA Research and Splicing
- Aquaculture disease management and microbiota
- Technology Use by Older Adults
- Regulation of Appetite and Obesity
- CRISPR and Genetic Engineering
- Neonatal Respiratory Health Research
- GDF15 and Related Biomarkers
- Antimicrobial Peptides and Activities
- Human-Animal Interaction Studies
- Protist diversity and phylogeny
- Fish Ecology and Management Studies
- Exercise and Physiological Responses
UiT The Arctic University of Norway
2018-2024
Centre for Arctic Gas Hydrate, Environment and Climate
2018-2024
University of Manchester
2008-2020
University of Liverpool
2007-2015
Genomics (United Kingdom)
2011-2015
Manchester University
2014
Highlights•A circannual timer may reside in the pituitary pars tuberalis thyrotroph•This is defined by a digital switching mechanism controlling EYA3 expression•The clockwork drives morphogenic cycle PT and hypothalamus•This involves recapitulation of developmental programSummaryPersistent free-running (approximately year-long) rhythms have evolved animals to regulate hormone cycles, drive metabolic (including hibernation), time annual reproduction. Recent studies photoperiodic input this...
Multiple studies characterizing the human ageing phenotype have been conducted for decades. However, there is no centralized resource in which data on multiple age-related changes are collated. Currently, researchers must consult several sources, including primary publications, order to obtain at various levels. To address this and facilitate integrative, system-level of we developed Digital Ageing Atlas (DAA). The DAA a one-stop collection covering different biological levels (molecular,...
Brain aging frequently underlies cognitive decline and is a major risk factor for neurodegenerative conditions. The exact molecular mechanisms underlying brain aging, however, remain unknown. Whole transcriptome sequencing provides unparalleled depth sensitivity in gene expression profiling. It also allows non-coding RNA splice variant detection/comparison across phenotypes. Using RNA-seq to sequence the cerebral cortex 6-, 12- 28-month-old rats, age-related changes were studied....
Caloric restriction (CR) can increase longevity in rodents and improve memory function humans. α-Lipoic acid (LA) has been shown to rats, but not longevity. While studies have looked at survival after switching from one diet another, the underlying mechanisms of beneficial effects CR LA supplementation are unknown. Here, we use RNA-seq cerebral cortex rats subjected LA-supplemented understand how changes affect aging, neurodegeneration Gene expression during aging ad libitum-fed largely...
The annual photoperiod cycle provides the critical environmental cue synchronizing rhythms of life in seasonal habitats. In 1936, Bünning proposed a circadian-based coincidence timer for photoperiodic synchronization plants. Formal studies support universality this so-called timer, but we lack understanding mechanisms involved. Here show mammals that long photoperiods induce circadian transcription factor BMAL2, pars tuberalis pituitary, and triggers summer biology through eyes...
In mammals, maternal photoperiodic programming (MPP) provides a means whereby juvenile development can be matched to forthcoming seasonal environmental conditions.
Abstract Background Although many diseases have been well characterized at the molecular level, underlying mechanisms are often unknown. Nearly half of all human genes remain poorly studied, yet these may contribute to a number disease processes. Genes involved in common biological processes and co-expressed. Using known disease-associated co-expression analysis help identify prioritize novel candidate for further study. Results We created an online tool, called GeneFriends, which identifies...
Dietary restriction (DR), limiting nutrient intake from diet without causing malnutrition, delays the aging process and extends lifespan in multiple organisms. The conserved life-extending effect of DR suggests involvement fundamental mechanisms, although these remain a subject debate. To help decipher mechanisms DR, we first compiled list genes that if genetically altered disrupt or prevent effects DR. We called DR–essential identified more than 100 model organisms such as yeast, worms,...
Atlantic salmon ( Salmo salar ) move from fresh- to seawater environments following a seasonally timed preparative transition called smoltification, which takes place under photoperiodic control in the freshwater environment. In masu Oncorhynchus masou ), coordination of sexual maturation is proposed involve fish-specific circumventricular organ, saccus vasculosus (SV), through its intrinsic opsin-based light sensitivity, thyrotrophin secretion and modulation deiodinase activity (TSH-DIO...
Anadromous salmonids begin life adapted to the freshwater environments of their natal streams before a developmental transition, known as smoltification, transforms them into marine-adapted fish. In wild, smoltification is photoperiod-regulated process, involving radical remodeling gill function cope with profound osmotic and immunological challenges seawater (SW) migration. While prior work has highlighted role specialized “mitochondrion-rich” cells (MRCs) accessory (ACs) in delivering this...
ABSTRACT Hibernation is an extreme state of seasonal energy conservation, reducing metabolic rate to as little 1% the active state. During hibernation season, many species hibernating mammals cycle repeatedly between (aroused) and (torpid) states (T–A cycling), using brown adipose tissue (BAT) drive cyclical rewarming. The regulatory mechanisms controlling this process remain undefined but are presumed involve thermoregulatory centres in hypothalamus. Here, we used golden hamster...
Abstract Genes potentially involved in the pathology of canine atopic dermatitis (AD) were identified using gene expression microarrays. Total RNA extracted from skin biopsies was hybridized to an Agilent Technologies custom‐designed 22K array. The arrays analysed Genedata Analyst software. Data corrected for multiple hypothesis testing and tested significance National Institute on Aging array analysis tool. For comparison, data divided into separate groups: lesional ( n = 16), nonlesional...
Across taxa, circadian control of physiology and behavior arises from cell-autonomous oscillations in gene expression, governed by a networks so-called 'clock genes', collectively forming transcription-translation feedback loops. In modern vertebrates, these contain multiple copies clock family members, which arose through whole genome duplication (WGD) events during evolutionary history. It remains unclear to what extent members are functionally redundant or have allowed for functional...
Regulation of mitochondrial oxidative phosphorylation is essential to match energy supply changing cellular demands, and cope with periods hypoxia. Recent work implicates the circadian molecular clock in control function hypoxia sensing. Because diving mammals experience intermittent episodes severe hypoxia, diel patterning dive depth duration, it interesting consider circadian-mitochondrial interaction this group. Here, we demonstrate that hooded seal (Cystophora cristata), a deep-diving...