A5075818416- Genetics, Aging, and Longevity in Model Organisms
- Bioinformatics and Genomic Networks
- Diet and metabolism studies
- Telomeres, Telomerase, and Senescence
- Single-cell and spatial transcriptomics
- Adipose Tissue and Metabolism
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Genomics and Phylogenetic Studies
- Genomics, phytochemicals, and oxidative stress
- Technology Use by Older Adults
- Machine Learning in Bioinformatics
- Mitochondrial Function and Pathology
- Glycosylation and Glycoproteins Research
- Coral and Marine Ecosystems Studies
- Birth, Development, and Health
- Wound Healing and Treatments
- Marine animal studies overview
- Marine Bivalve and Aquaculture Studies
- Circadian rhythm and melatonin
- Gene expression and cancer classification
- Nutrition, Genetics, and Disease
- Health, Environment, Cognitive Aging
- Neuroinflammation and Neurodegeneration Mechanisms
- Histone Deacetylase Inhibitors Research
Romanian Academy
2012-2024
Institute of Biochemistry
2012-2024
Genomics (United Kingdom)
2013-2020
University of Liverpool
2013-2020
Chronos (France)
2019
Ben-Gurion University of the Negev
2008-2016
In spite of a growing body research and data, human ageing remains poorly understood process. Over 10 years ago we developed the Human Ageing Genomic Resources (HAGR), collection databases tools for studying biology genetics ageing. Here, present HAGR's main functionalities, highlighting new additions improvements. HAGR consists six core databases: (i) GenAge database ageing-related genes, in turn composed dataset >300 genes with >2000 associated or longevity model organisms; (ii) AnAge...
The Human Ageing Genomic Resources (HAGR, http://genomics.senescence.info) is a freely available online collection of research databases and tools for the biology genetics ageing. HAGR features now several with high-quality manually curated data: (i) GenAge, database genes associated ageing in humans model organisms; (ii) AnAge, an extensive longevity records complementary traits >4000 vertebrate species; (iii) GenDR, newly incorporated database, containing both gene mutations that interfere...
Cellular senescence, a permanent state of replicative arrest in otherwise proliferating cells, is hallmark aging and has been linked to aging-related diseases. Many genes play role cellular yet comprehensive understanding its pathways still lacking.
The role of cellular senescence (CS) in age-related diseases (ARDs) is a quickly emerging topic aging research. Our comprehensive data mining revealed over 250 genes tightly associated with CS. Using systems biology tools, we found that CS closely interconnected aging, longevity and ARDs, either by sharing common regulators or protein-protein interactions eventually signaling pathways. most enriched pathways across CS, ARDs aging-associated conditions (oxidative stress chronic inflammation)...
Multiple studies characterizing the human ageing phenotype have been conducted for decades. However, there is no centralized resource in which data on multiple age-related changes are collated. Currently, researchers must consult several sources, including primary publications, order to obtain at various levels. To address this and facilitate integrative, system-level of we developed Digital Ageing Atlas (DAA). The DAA a one-stop collection covering different biological levels (molecular,...
Caloric restriction (CR), a reduction in calorie intake without malnutrition, retards aging several animal models from worms to mammals. Developing CR mimetics, compounds that reproduce the longevity benefits of its side effects, is widespread interest. Here, we employed Connectivity Map identify drugs with overlapping gene expression profiles CR. Eleven statistically significant were predicted as mimetics using this bioinformatics approach. We then tested rapamycin, allantoin, trichostatin...
In model organisms, over 2,000 genes have been shown to modulate aging, the collection of which we call 'gerontome'. Although some individual aging-related subject intense scrutiny, their analysis as a whole has limited. particular, genetic interaction aging and age-related pathologies remain debate. this work, perform systematic gerontome across species, including human genes. First, by classifying pro- or anti-longevity, define distinct pathways that in different ways. Our subsequent...
Caloric restriction (CR) can increase longevity in rodents and improve memory function humans. α-Lipoic acid (LA) has been shown to rats, but not longevity. While studies have looked at survival after switching from one diet another, the underlying mechanisms of beneficial effects CR LA supplementation are unknown. Here, we use RNA-seq cerebral cortex rats subjected LA-supplemented understand how changes affect aging, neurodegeneration Gene expression during aging ad libitum-fed largely...
Abstract Supervised machine learning models rely on training datasets with positive (target class) and negative examples. Therefore, the composition of dataset has a direct influence model performance. Specifically, sample selection bias, concerning samples not representing target class, presents challenges across range domains such as text classification protein-protein interaction prediction. Machine-learning-based immunotherapeutics design is an increasingly important area research,...
Intricate and interconnected pathways modulate longevity, but screens to identify the components of these have not been saturating. Because biological processes are often executed by protein complexes fine-tuned regulatory factors, first-order protein-protein interactors known longevity genes likely participate in regulation longevity. Data-rich maps interactions established for many cardinal organisms such as yeast, worms, humans. We propose that interaction could be mined identification...
Leucine-rich-repeats (LRRs) belong to an archaic procaryal protein architecture that is widely involved in protein-protein interactions. In eukaryotes, LRR domains developed into key recognition modules many innate immune receptor classes. Due the high sequence variability imposed by specificity, precise repeat delineation often difficult especially plant NOD-like Receptors (NLRs) notorious for showing far larger irregularities. To address this problem, we introduce here LRRpredictor, a...
Abstract One important question in aging research is how differences genomics and transcriptomics determine the maximum lifespan various species. Despite recent progress, much still unclear on topic, partly due to lack of samples nonmodel organisms challenges direct comparisons transcriptomes from different The novel ranking‐based method that we employ here used analyze gene expression gray whale compare its de novo assembled transcriptome with other long‐ short‐lived mammals. Gray whales...
Hundreds of genes, when manipulated, affect the lifespan model organisms (yeast, worm, fruit fly, and mouse) thus can be defined as longevity-associated genes (LAGs). A major challenge is to determine whether these LAGs are model-specific or may play a universal role longevity regulators across diverse taxa. wide-scale comparative analysis 1805 known 205 species revealed that (i) LAG orthologs substantially overrepresented, from bacteria mammals, compared entire genomes interactomes, this...
Dysregulation of intercellular communication is a hallmark aging. To better quantify and explore changes in communication, we present scDiffCom scAgeCom. an R package, relying on approximately 5,000 curated ligand-receptor interactions, that performs differential analysis between two conditions from single-cell transcriptomics data. Built upon scDiffCom, scAgeCom atlas age-related cell-cell covering 23 mouse tissues 58 RNA sequencing datasets Tabula Muris Senis the Calico murine aging cell...
Mitochondria are the only organelles in animal cells that have their own genome. Due to a key role energy production, generation of damaging factors (ROS, heat), and apoptosis, mitochondria mtDNA particular long been considered one major players mechanisms aging, longevity age-related diseases. The rapidly increasing number species with fully sequenced mtDNA, together accumulated data on records, provides new fascinating basis for comparative analysis links between features longevity. To...
In spite of enormous efforts and accumulated knowledge, our capabilities for tackling aging age-related diseases (ARDs), ultimately to promote longevity, are still very modest. What is lacking—essential data on key players, efficient analytic tools, or both? Here we discuss how the existing may be integrated analyzed in context microRNA (miRNA)-regulated protein–protein interaction networks. The proposed model highlighted: (1) strong molecular links between aging, ARDs; (2) possibility even...
Abstract Accumulating metabolomics data is starting to become extremely useful in understanding the ageing process, by providing a snapshot into metabolic state of tissues and organs, at different ages. Molecular studies such variations during “normal” can hence guide lifestyle changes and/or medical interventions aimed improving healthspan perhaps even lifespan. In this work, we present MetaboAge, freely accessible database which hosts ageing-related metabolite changes, occurring healthy...
Abstract Interventional studies on genetic modulators of longevity have significantly changed gerontology. While available lifespan data are continually accumulating, further understanding the aging process is still limited by poor epistasis and non-linear interactions between multiple longevity-associated genes. Unfortunately, based observations so far, there no simple method to predict cumulative impact genes lifespan. As a step towards applying predictive methods, but also provide...
If somatic stem cells would be able to maintain their regenerative capacity over time, this might, a great extent, resolve rejuvenation issues. Unfortunately, the pool of is limited, and they undergo cell aging with consequent loss functionality. During last decade, low molecular weight compounds that are induce or enhance reprogramming have been reported. They were named âSmall Moleculesâ (SMs) might present definite advantages compared exogenous introduction stemness-related...