A5010330353- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Monoclonal and Polyclonal Antibodies Research
- Rheumatoid Arthritis Research and Therapies
- Inflammatory Myopathies and Dermatomyositis
- Genetic Associations and Epidemiology
- Immune Cell Function and Interaction
- Vasculitis and related conditions
- Genetics and Neurodevelopmental Disorders
- Immunotherapy and Immune Responses
- Diabetes and associated disorders
- Celiac Disease Research and Management
- Cell Adhesion Molecules Research
- Immunodeficiency and Autoimmune Disorders
- Lymphoma Diagnosis and Treatment
- Urticaria and Related Conditions
- Chronic Lymphocytic Leukemia Research
- Viral Infections and Immunology Research
- Atherosclerosis and Cardiovascular Diseases
- Autoimmune and Inflammatory Disorders Research
- Cognitive Abilities and Testing
- Immune Response and Inflammation
- Dermatologic Treatments and Research
- Inflammasome and immune disorders
- Bioinformatics and Genomic Networks
Manchester Metropolitan University
2019-2024
University of Manchester
2014-2023
NIHR Manchester Biomedical Research Centre
2005-2023
Manchester Academic Health Science Centre
2012-2022
Health Sciences Centre
2022
Salford Royal NHS Foundation Trust
2008-2018
Manchester University NHS Foundation Trust
2018
Primary Health Care
1984-2017
Genomics (United Kingdom)
2016
Manchester University
1994-2014
Abstract Objective Cardiovascular (CV) disease is the most common cause of mortality in patients with rheumatoid arthritis (RA). We assessed contribution epidemiologic features, clinical routine laboratory markers inflammation, and HLA–DRB1 alleles to CV RA prospectively followed at a single referral center Spain. Methods Patients fulfilling 1987 American College Rheumatology classification criteria for seen rheumatology outpatient clinic Hospital Xeral‐Calde, Lugo between March September...
<h3>Objectives:</h3> There is a known association between myositis and cancer. The risk greater in dermatomyositis (DM) than polymyositis (PM), although reliable methods to predict cancer specific patients with are not presently available. This study was undertaken determine whether of developing can be predicted by antibody profiling. <h3>Methods:</h3> A cross-sectional UK Caucasian adults PM (n = 109), DM 103) connective tissue disease overlap (myositis/CTD-overlap, n 70). Patients were...
Giant cell (temporal) arteritis (GCA) is the most common systemic vasculitis in Western countries. It involves large and medium-sized vessels with predisposition to cranial arteries elderly. Cranial ischemic complications, particular permanent visual loss, constitute feared aspects of this vasculitis. Although use corticosteroids a higher physician awareness may have contributed decrease frequency severe loss still present 7%-14% patients. To investigate further incidence, trends, clinical...
Section:ChooseTop of pageAbstract <<METHODSRESULTSDISCUSSIONCONCLUSIONSReferencesCITING ARTICLES
The UK Biobank is a major collaborative research project to recruit and follow longitudinally the health of 500,000 volunteers aged between 40-69 years. It will provide important biological samples environmental exposure data. As such, it constitute resource for many future investigations separate combined effects genetic, lifestyle factors on human morbidity, mortality health.
Abstract Objective To undertake a systematic whole‐genome screen to identify regions exhibiting genetic linkage rheumatoid arthritis (RA). Methods Two hundred fifty‐two RA‐affected sibling pairs from 182 UK families were genotyped using 365 highly informative microsatellite markers. Microsatellite genotyping was performed fluorescent polymerase chain reaction primers and semiautomated DNA sequencing technology. Linkage analysis undertaken MAPMAKER/SIBS for single‐point multipoint analysis....
Objective To determine if polymorphisms of the macrophage migration inhibitory factor (MIF) gene are associated with systemic-onset juvenile idiopathic arthritis (JIA). Methods Denaturing high-performance liquid chromatography was used to screen for MIF in 32 healthy Caucasian subjects. One hundred seventeen UK patients JIA and 172 unrelated controls were genotyped a single-nucleotide polymorphism (SNP) identified 5′-flanking region gene, using polymerase chain...
<h3>Objectives:</h3> Autoantibodies to a novel autoantigen small ubiquitin-like modifier activating enzyme (SAE) associated with dermatomyositis (DM) have previously been identified. The aim of this study was establish the frequency anti-SAE autoantibodies in UK myositis cohort and investigate clinicoimmunogenetic associations. <h3>Methods:</h3> Clinical data sera were studied from 266 patients recruited Adult Onset Myositis Immunogenetic Collaboration. sera, control including 250 other...
The personality traits of neuroticism and extraversion are predictive a number social behavioural outcomes psychiatric disorders. Twin family studies have reported moderate heritability estimates for both traits. Few associations been between genetic variants neuroticism/extraversion, but hardly any replicated. Moreover, the ones that replicated explain only small proportion (<∼2%). Using genome-wide single-nucleotide polymorphism (SNP) data from ∼12 000 unrelated individuals we estimated...
Animals might be able to use highly polymorphic genetic markers recognize very close relatives and avoid inbreeding. The major histocompatibility complex (MHC) is thought provide such a marker because it influences individual scent in broad range of vertebrates. However, direct evidence limited. In house mice (Mus musculus domesticus), the urinary protein (MUP) gene cluster provides another signal identity that could underlie kin recognition. We demonstrate wild breeding freely seminatural...
The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of rare autoimmune diseases characterised by muscle weakness and extramuscular manifestations such as skin rashes interstitial lung disease. We genotyped 2566 IIM cases Caucasian descent using the Immunochip; custom array covering 186 established susceptibility loci. cohort was predominantly comprised patients with dermatomyositis (DM, n=879), juvenile DM (JDM, n=481), polymyositis (PM, n=931) inclusion body myositis...
To identify new genetic associations with juvenile and adult dermatomyositis (DM).