A5020497851- Bariatric Surgery and Outcomes
- Diabetes Treatment and Management
- Diet and metabolism studies
- Asthma and respiratory diseases
- Chronic Disease Management Strategies
- Chronic Kidney Disease and Diabetes
- Respiratory and Cough-Related Research
- Diabetes Management and Education
- Diabetes Management and Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Dialysis and Renal Disease Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Body Contouring and Surgery
- Electronic Health Records Systems
- Diabetes and associated disorders
- Medication Adherence and Compliance
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Growth Hormone and Insulin-like Growth Factors
- Inhalation and Respiratory Drug Delivery
- Blood Pressure and Hypertension Studies
- Mobile Health and mHealth Applications
- Pancreatic function and diabetes
- Health Systems, Economic Evaluations, Quality of Life
- Adipose Tissue and Metabolism
- Heart Failure Treatment and Management
Salford Royal NHS Foundation Trust
2014-2024
Salford Royal Hospital
2002-2022
University of Manchester
2013-2022
Manchester Academic Health Science Centre
2010-2021
University of California, San Diego
2011
Drexel University
2011
Manchester University
2008
University of Salford
2000-2007
Maryland Medical Research Institute
2007
St George's, University of London
2007
Evidence for the management of chronic obstructive pulmonary disease (COPD) comes from closely monitored efficacy trials involving groups patients who were selected on basis restricted entry criteria. There is a need randomized to be conducted in conditions that are closer usual clinical practice.In controlled effectiveness trial 75 general practices, we randomly assigned 2799 with COPD once-daily inhaled combination fluticasone furoate at dose 100 μg and vilanterol 25 (the...
Higher phosphate is associated with mortality in dialysis patients but few prospective studies assess this nondialysis managed an outpatient nephrology clinic. This longitudinal study examined whether level was death a referred population.Patients (1203) of chronic kidney disease (CKD) the Chronic Renal Insufficiency Standards Implementation Study were assessed. Survival analyses performed for quartiles baseline relative to GFR, 12-month time-averaged phosphate, and according published...
Background. Diabetes mellitus and chronic kidney disease (CKD) are common exhibit synergistic associations with premature mortality. Current diabetes guidelines in the UK recommend annual urinary albumin serum creatinine determinations to screen for diabetic disease. The aim of this study was estimate burden CKD patients examine ability albuminuria detect clinically meaningful compared estimated glomerular filtration rate (eGFR).
OBJECTIVE—To determine the effectiveness of specialist nurse-led clinics for hypertension and hyperlipidemia provided diabetic patients receiving hospital-based care. RESEARCH DESIGN AND METHODS—This study was a randomized controlled implementation trial at Hope Hospital, Salford, U.K. The subjects consisted 1,407 presenting annual review with raised blood pressure (≥140/80 mmHg), total cholesterol (≥5.0 mmol/l), or both. Individuals diabetes were to usual care subsequent invitation attend...
OBJECTIVE: To evaluate the performance of a hand-held ketone sensor that is able to measure blood beta-hydroxybutyrate (beta-HBA) concentrations within 30 s in patients with diabetic ketoacidosis (DKA) and who attend weight management clinic. RESEARCH DESIGN AND METHODS: Two groups were studied: 19 admitted DKA 156 attending Paired capillary venous whole samples measured using also an enzymatic laboratory reference method. RESULTS: The accurately beta-HBA (limits agreement -0.9 + 1.0 mmol/l)...
Abstract Aims To compare rates of chronic kidney disease (CKD) in patients with diabetes and management risk factors compared people without using general practice computer records, to assess the utility serum creatinine albuminuria as markers impaired renal function. Methods The simplified Modification Diet Renal Disease (MDRD) equation was used estimate glomerular filtration rate (eGFR) stage CKD. Further data were extracted how effectively function being identified well potentially...
We need to assess clinical treatments in real-life settings outside of randomised controlled trials (RCTs). Pragmatic RCT (pRCT) data can supplement RCTs by providing effectiveness information support healthcare decisions. Electronic health records facilitate concurrent safety monitoring and collection without direct patient contact for large study populations pRCTs. The Salford Lung Study is the world9s first phase III pRCT asthma chronic obstructive pulmonary disease (COPD), which aims...
To investigate the best glucose monitoring strategy for maintaining euglycaemia by comparing self-monitoring of blood with continuous monitoring, or without an alarm function.A 100-day, randomized controlled study was conducted at four European centres, enrolling 160 patients Type 1 2 diabetes, on multiple daily insulin injections subcutaneous infusion. Participants were to alarms (n = 48), 49) 48).Time spent outside target during days 80-100 9.9 h/day group, 9.7 group and 10.6 (P 0.18 0.08...
OBJECTIVE— To determine whether Pro-Active Call Center Treatment Support (PACCTS), using trained nonmedical telephonists supported by specially designed software and a diabetes nurse, can effectively improve glycemic control in type 2 diabetes. RESEARCH DESIGN AND METHODS— A randomized controlled implementation trial of 1-year duration was conducted Salford, U.K. The comprised 591 randomly selected individuals with By random allocation, 197 were assigned to the usual care (control) group 394...
Abstract Background Anaemia occurs early in the course of diabetes‐related chronic kidney disease (CKD). There is little evidence about prevalence anaemia people with diabetes. The aim this study was to assess anaemia, by stage CKD, general diabetic population. Methods Haemoglobin (Hb) measured on all glycated haemoglobin (HbA 1c ) samples and most recent (< 4 months) estimated glomerular filtration rate (eGFR) obtained. (at treatment level) defined as Hb < 110 g/l or use erythropoetic...
Background. There have been few attempts to estimate progression of kidney disease in people with diabetes a single large population predictive modelling. The aim this study was investigate the rate chronic according their estimated glomerular filtration (eGFR) and presence albuminuria. Methods. Data were collected on all Salford, UK, where an eGFR could be calculated using four-variable MDRD formula urinary albumin–creatinine ratio (uACR) available. All data between 2001 2007 used model....
Obesity is a major modifiable risk factor for cardiovascular disease. Bariatric surgery considered to be the most effective treatment option weight reduction in obese patients with and without type 2 diabetes (T2DM).To evaluate changes lipoproteins, insulin resistance, mediators of systemic vascular inflammation, endothelial dysfunction following Roux-en-Y bariatric diabetes.Lipoproteins, were measured 37 (n = 17) 20) T2DM, before 6 12 months after surgery. Two way between subject ANOVA was...
OBJECTIVE—To derive and validate an absolute risk algorithm for major coronary heart disease (CHD) events in the U.K. population with type 2 diabetes. RESEARCH DESIGN AND METHODS—A cohort diabetes was constructed Tayside, Scotland, U.K., longitudinally followed-up to June 2004. Participants were all people registered general practices Diabetes Audit Research database (97% sensitive) no previous CHD event complete measurements (n = 4,569). The main outcome measure of defined as fatal or...
Novel therapies need to be evaluated in normal clinical practice allow a true representation of the treatment effectiveness real-world settings. The Salford Lung Study is pragmatic randomised controlled trial adult asthma, evaluating and safety once-daily fluticasone furoate (100 μg or 200 μg)/vilanterol 25 novel dry-powder inhaler, versus existing asthma maintenance therapy. study was initiated before this investigational licensed conducted consider adherence, co-morbidities, polypharmacy,...
New treatments need to be evaluated in real-world clinical practice account for co-morbidities, adherence and polypharmacy. Patients with chronic obstructive pulmonary disease (COPD), ≥40 years old, exacerbation the previous 3 are randomised 1:1 once-daily fluticasone furoate 100 μg/vilanterol 25 μg a novel dry-powder inhaler versus continuing their existing therapy. The primary endpoint is mean annual rate of COPD exacerbations; an electronic medical record allows real-time collection...
OBJECTIVE—To determine the cost-effectiveness of specialist nurse–led clinics provided to improve lipid and blood pressure control in diabetic patients receiving hospital-based care. RESEARCH DESIGN AND METHODS—A policy targeting improved care through is evaluated using a novel method, linking antihypertensive lipid-lowering treatments with cost level behavioral change achieved by clinics. Treatment modeled from U.K. Prospective Diabetes Study Heart Protection treatment trials, whereas are...
Real-world data on the benefit/risk profile of medicines is needed, particularly in patients who are ineligible for randomised controlled trials conducted registration purposes. This paper describes methodology and source verification which enables conduct pre-licensing clinical COPD asthma community using electronic medical record (EMR), NorthWest EHealth linked database (NWEH-LDB) alert systems.Dual extracts into NWEH-LDB was performed two independent sources (Salford Integrated Record...
Refractory and unexplained chronic cough (RCC UCC) necessitate frequent referral for specialist evaluations, but data on healthcare resource utilisation costs are lacking.