A5043941957- Pharmacology and Obesity Treatment
- Diabetes Treatment and Management
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Eating Disorders and Behaviors
- Receptor Mechanisms and Signaling
- Obesity, Physical Activity, Diet
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Nutrition and Health in Aging
- Acne and Rosacea Treatments and Effects
- Hormonal and reproductive studies
- Muscle metabolism and nutrition
- ECG Monitoring and Analysis
- Health and Lifestyle Studies
- Biochemical Analysis and Sensing Techniques
- Heart Rate Variability and Autonomic Control
- Skin Protection and Aging
- Sleep and related disorders
- Sperm and Testicular Function
- Adipose Tissue and Metabolism
- Obesity and Health Practices
- Psoriasis: Treatment and Pathogenesis
- Vitamin D Research Studies
University of Copenhagen
2017-2024
Novo Nordisk Foundation
2019-2021
Universidade Federal de Minas Gerais
2019
Queen Mary University of London
2019
Leiden University Medical Center
2019
Gentofte Hospital
2011
Weight regain after weight loss is a major problem in the treatment of persons with obesity.In randomized, head-to-head, placebo-controlled trial, we enrolled adults obesity (body-mass index [the kilograms divided by square height meters], 32 to 43) who did not have diabetes. After an 8-week low-calorie diet, participants were randomly assigned for 1 year one four strategies: moderate-to-vigorous-intensity exercise program plus placebo (exercise group); liraglutide (3.0 mg per day) usual...
Abstract Background Identifying and reducing cardiometabolic risks driven by obesity remains a healthcare challenge. The metabolic syndrome is associated with abdominal inflammation predictive of long-term risk developing type 2 diabetes cardiovascular disease in otherwise healthy individuals living obesity. Therefore, we investigated the effects adherent exercise, glucagon-like peptide 1 receptor agonist (GLP-1 RA), or combination on severity syndrome, obesity, following weight loss....
BackgroundNew obesity medications result in large weight losses. However, long-term adherence a real-world setting is challenging, and termination of medication results regain towards pre-treatment body weight. Therefore, we investigated whether loss improved composition are sustained better at 1 year after active treatment with glucagon-like peptide-1 (GLP-1) receptor agonist, supervised exercise program, or both combined for year.MethodsWe conducted post-treatment study extension...
Importance A major concern with weight loss is concomitant bone loss. Exercise and glucagon-like peptide-1 receptor agonists (GLP-1RAs) represent strategies that may protect mass despite Objective To investigate health at clinically relevant sites (hip, spine, forearm) after diet-induced followed by a 1-year intervention exercise, liraglutide, or both combined. Design, Setting, Participants This study was predefined secondary analysis of randomized clinical trial conducted between August...
Abstract STUDY QUESTION Does diet-induced weight loss improve semen parameters, and are these possible improvements maintained with sustained loss? SUMMARY ANSWER An 8-week low-calorie was associated improved sperm concentration count, which were after 1 year in men who loss. WHAT IS KNOWN ALREADY Obesity is impaired quality. Weight improves metabolic health obesity, but there a lack of knowledge on the acute long-term effects parameters. DESIGN, SIZE, DURATION This substudy obesity enrolled...
Abstract Weight regain after weight loss remains a major challenge in obesity treatment and may involve alteration of eating sedentary behavior loss. In this randomized, controlled, double-blind trial, adults with were 1:1:1:1 ratio stratified by sex age group (<40 years ≥40 years), to one-year maintenance exercise, the GLP-1 receptor agonist liraglutide, or combination, as compared placebo, low-calorie diet-induced Primary outcome was change body weight, which has been published. Here,...
Abstract Objective The aim of this study was to investigate glucose tolerance, glucagon response, and beta cell function during a 1‐year maintenance period with either exercise, the glucagon‐like peptide‐1 receptor agonist liraglutide, or combination after diet‐induced weight loss. Methods In randomized placebo‐controlled trial, adults obesity (BMI: 32–43 kg/m 2 ) without diabetes underwent an 8‐week low‐calorie diet (800 kcal/d) were 52 weeks aerobic liraglutide 3.0 mg/d, exercise combined,...
Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease, recently associated with metabolic syndrome, subclinical atherosclerosis and increased risk of cardiovascular disease.To investigate the hitherto unknown electrocardiographic (ECG) changes HS, which have been significant burden.Data were obtained from cross-sectional Danish General Population Study (GESUS). HS diagnosis was based on validated self-reported questionnaire; 404 individuals met criteria 19 001 controls...
Whether there is a causal relationship between milk intake and acne unknown. We tested the hypothesis that genetically determined associated with in adults using Mendelian randomization design. LCT-13910 C/T (rs4988235) lactase persistence (TT/TC) Northern Europeans. investigated association intake, (rs4988235), 20,416 (age-range: 20–96) from The Danish General Suburban Population Study (GESUS). adjusted observational odds ratio for any vs. no was 0.93(95% confidence interval: 0.48–1.78)...
Introduction The success rate of weight loss maintenance is limited. Therefore, the purpose this study to investigate and immunometabolic health outcomes after diet-induced followed by 1-year treatment with a glucagon-like peptide-1 receptor agonist (liraglutide), physical exercise or combination both treatments as compared placebo in individuals obesity. Methods analysis This an investigator-initiated, randomised, placebo-controlled, parallel group trial. We will enrol expectedly 200 women...
The voltage-gated potassium channel Kv7.1 encoded by KCNQ1 is located in both cardiac myocytes and insulin producing beta cells. Loss-of-function mutations causes long QT syndrome along with glucose-stimulated hyperinsulinemia, increased C-peptide postprandial hypoglycemia. KCNE1 protein modulates myocytes, but not expressed Gain-of-function shorten the action potential duration their effect on cells secretion unknown.Two patients atrial fibrillation due to gain-of-function (R670K) (G60D)...
Abstract Context Obesity is associated with low vitamin D status -, and recent studies have suggested a difference in metabolism between females males. Objective The aim of this study was to investigate the effects weight loss on individuals obesity, secondarily, whether differs women men. Methods Secondary analysis from randomized placebo-controlled trial, designed efficacy 52 weeks treatment either liraglutide, exercise, or both combined compared placebo maintenance after an 8-week...
The voltage-gated potassium channel Kv 11.1 is important for repolarizing the membrane potential in excitable cells such as myocytes, pancreatic α- and β-cells. Moxifloxacin blocks increases risk of hypoglycaemia patients with diabetes. We investigated glucose regulation secretion glucoregulatory hormones young people without moxifloxacin, a drug known to block channel.The effect moxifloxacin (800 mg/day 4 days) or placebo on was assessed randomized, double-blind, crossover study men women...
Abstract Study Objectives Insufficient sleep may attenuate weight loss, but the role of in loss maintenance is unknown. Since regain after remains a major obstacle obesity treatment, we investigated whether insufficient predicts during maintenance. Methods In randomized, controlled, two-by-two factorial study, 195 adults with completed an 8-week low-calorie diet and were randomly assigned to 1-year or without exercise liraglutide 3.0 mg/day placebo. Sleep duration quality measured before...
Background: Physical inactivity and obesity are associated with short sleep duration poor quality of sleep. The aim was to explore the impact on habits a diet-induced weight loss followed by three maintenance strategies: Exercise training, GLP-1 receptor agonist (liraglutide), combination both treatments. Methods: Exploratory analyses from randomized trial S-LITE (NCT 04122716). Participants (BMI 32-43 kg/m2) were included 8 weeks very low-calorie diet (VLCD) 800 kcal/day 1-year treatment 1)...
Introduction: Improved cardiorespiratory fitness (CRF) is associated with reduced mortality. Each metabolic equivalent (MET) increase in CRF 10-25 % improvements survival. The aim was to explore changes during weight maintenance the glucagon-like peptide-1 receptor agonist liraglutide and/or exercise. Methods: Women and men obesity (18-65 years, BMI 32-43 kg/m2) who achieved ≥ 5 loss an 8-week very low-calorie diet (VLCD) were randomized (1) 3 mg/day (LIRA), (2) exercise 150 min/week +...