Marten E. van den Berg
A5081327643- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- ECG Monitoring and Analysis
- Genetic Associations and Epidemiology
- Heart Rate Variability and Autonomic Control
- Cardiomyopathy and Myosin Studies
- Heart rate and cardiovascular health
- Receptor Mechanisms and Signaling
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Cardiac Imaging and Diagnostics
- Congenital heart defects research
- Blood Pressure and Hypertension Studies
- Cardiac Arrest and Resuscitation
- Thyroid Disorders and Treatments
- Respiratory and Cough-Related Research
- Magnesium in Health and Disease
- Gastroesophageal reflux and treatments
- Acute Myocardial Infarction Research
- Birth, Development, and Health
- Heart Failure Treatment and Management
- Heat shock proteins research
- Neuroscience of respiration and sleep
Erasmus MC
2014-2023
Erasmus University Rotterdam
2015-2021
Framingham Heart Study
2018
Boston University
2018
National Heart Lung and Blood Institute
2018
Dutch Health Care Inspectorate
2016
Harvard University
2016
University of Groningen
1988
Background Low serum magnesium has been implicated in cardiovascular mortality, but results are conflicting and the pathway is unclear. We studied association of with coronary heart disease ( CHD ) mortality sudden cardiac death SCD within prospective population‐based Rotterdam Study, adjudicated end points long‐term follow‐up. Methods Results Nine‐thousand eight‐hundred twenty participants (mean age 65.1 years, 56.8% female) were included a median follow‐up 8.7 years. used multivariable Cox...
Both sudden cardiac death (SCD) and chronic obstructive pulmonary disease (COPD) are common conditions in the elderly. Previous studies have identified an association between COPD cardiovascular disease, with SCD specific patient groups. Our aim was to investigate whether there is general population. The Rotterdam study a population-based cohort among 14 926 subjects aged 45 years older up 24 of follow-up. Analyses were performed (time dependent) Cox proportional hazard model adjusted for...
Purpose: Heart-rate variability (HRV) measured on standard 10-second electrocardiograms (ECGs) has been associated with increased risk of cardiac and all-cause mortality, but age- sex-dependent normal values have not established. Since heart rate strongly affects HRV, its effect should be taken into account. We determined a comprehensive set heart-rate corrected HRV derived from ECGs for both children adults, covering sexes. Methods: Five population studies in the Netherlands (Pediatric...
BACKGROUND: The association between thyroid function and cardiovascular disease is well established, but no study to date has assessed whether it a risk factor for sudden cardiac death (SCD). Therefore, we studied the of with SCD in prospective population-based cohort. METHODS: Participants from Rotterdam Study ≥45 years thyroid-stimulating hormone or free thyroxine (FT4) measurements clinical follow-up were eligible. We FT4 by using an age- sex-adjusted Cox proportional-hazards model, all...
Abstract The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization and repolarization, estimated by QRS duration JT interval, respectively. abnormalities are associated with potentially fatal arrhythmia. Using genome-wide multi-ancestry analyses (>250,000 individuals) we identify 177, 156 121 independent loci for QT, QRS, respectively, including a male-specific X-chromosome locus. gene-based rare-variant methods, associations Mendelian disease...
Aims Selective serotonin re‐uptake inhibitors (SSRIs), specifically citalopram and escitalopram, are thought to cause QT c prolongation, although studies have shown contradictory results. Nevertheless, a maximum dosage of 20 mg in high risk patients (e.g. >60 years age) is recommended. We aimed investigate the association between use (individual) SSRIs population‐based study older adults. Methods This study, which was part prospective Rotterdam Study (period 1991–2012), included...
Resting heart rate is a heritable trait, and an increase in associated with increased mortality risk. Genome-wide association study analyses have found loci resting rate, at the time of our these explained 0.9% variation. This aims to discover new genetic from Exome Chip meta-analyses.Heart was measured either elecrtrocardiograms or pulse recordings. We meta-analysed results 104 452 European-ancestry individuals 30 cohorts, genotyped using Chip. Twenty-four variants were selected for...
Background Tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs) may be associated with lower heart rate variability (HRV), a condition increased mortality risk. We aimed to investigate the association between TCAs, SSRIs HRV in population-based study. Method In prospective Rotterdam Study cohort, up five electrocardiograms (ECGs) per participant were recorded (1991–2012). Two variables studied based on 10-s ECG recordings: standard deviation of...
The ST-segment and adjacent T-wave (ST-T wave) amplitudes of the electrocardiogram are quantitative characteristics cardiac repolarization. Repolarization abnormalities have been linked to ventricular arrhythmias sudden death. We performed first genome-wide association meta-analysis ST-T-wave in up 37 977 individuals identifying 71 robust genotype–phenotype associations clustered within 28 independent loci. Fifty-four genes were prioritized as candidates underlying phenotypes, including with...
The ATP-binding cassette B1 (ABCB1) gene encodes P-glycoprotein, a transport protein, which plays an important role in the bioavailability of digoxin. We aimed to investigate interaction between variants within ABCB1 and digoxin on risk sudden cardiac death (SCD).Within Rotterdam Study, population-based cohort study persons 45 years age older, we used Cox regression analyse association three polymorphisms that have been associated with bioavailability, extracted from 1000-Genomes imputed...
A prolonged heart rate corrected QT interval (QTc) increases the risk of sudden cardiac death. Some methods correction (notably Bazett) overestimate QTc in people with high rates. Studies suggest that tricyclic antidepressants (TCAs) can prolong and increase rate. Therefore, we aimed to study whether TCA-induced prolongation is a false-positive observation due overestimation at For this, included 12,734 participants from prospective population-based Rotterdam Study, total 27,068...
Purpose Prolonged ventricular repolarization (measured as heart-rate corrected QT (QTc) prolongation or JT-interval prolongation) is a risk factor for arrhythmias and can be drug-induced. Drugs classified having known possible QTc-prolonging properties. Regulatory agencies recommend avoiding concomitant use of multiple drugs, but evidence lacking to what degree influenced by these drugs. Methods Within population-based cohort persons aged 45 years older, with up five electrocardiograms...
Aims: QT variability is a promising electrocardiographic marker. It has been studied as screening tool for coronary artery disease and left ventricular hypertrophy, increased known risk factor sudden cardiac death. Considering that comprehensive normal values were lacking, we set out to establish these in standard 10-s electrocardiograms (ECGs) covering both sexes all ages. Methods: Ten-second, 12-lead ECGs provided by five Dutch population studies (Pediatric Normal ECG Study, Leiden...