A5003774654- Analytical Chemistry and Chromatography
- Analytical Methods in Pharmaceuticals
- Advanced Chemical Sensor Technologies
- Computational Drug Discovery Methods
- Crystallization and Solubility Studies
- Chromatography in Natural Products
- Thermodynamic properties of mixtures
- Drug Solubulity and Delivery Systems
- Microbial Natural Products and Biosynthesis
- Fungal Biology and Applications
- Heart rate and cardiovascular health
- Global Energy Security and Policy
- Steroid Chemistry and Biochemistry
- Cardiac electrophysiology and arrhythmias
- ECG Monitoring and Analysis
- Hybrid Renewable Energy Systems
- Antibiotics Pharmacokinetics and Efficacy
- Protein purification and stability
- Microfluidic and Capillary Electrophoresis Applications
- Renewable energy and sustainable power systems
- Pharmacological Effects of Medicinal Plants
- Receptor Mechanisms and Signaling
- Pharmacogenetics and Drug Metabolism
- Spectroscopy and Chemometric Analyses
- Chemical synthesis and alkaloids
University of Belgrade
2013-2021
Deleted Institution
2018-2021
Aims Selective serotonin re‐uptake inhibitors (SSRIs), specifically citalopram and escitalopram, are thought to cause QT c prolongation, although studies have shown contradictory results. Nevertheless, a maximum dosage of 20 mg in high risk patients (e.g. >60 years age) is recommended. We aimed investigate the association between use (individual) SSRIs population‐based study older adults. Methods This study, which was part prospective Rotterdam Study (period 1991–2012), included...
Most commonly used analytical technique for determination of active pharmaceutical ingredients and their impurities in quality control throughout all phases drug research, development manufacture is definitely reversed-phase high performance liquid chromatography (RP-HPLC). However, industry professionals are often faced with various challenges RP mode, which cannot be resolved common variations the composition mobile phase. These occur when analyzing compounds that contain basic ionizable...
Abstract The charged aerosol detector (CAD) is the latest representative of aerosol-based detectors that generate a response independent analytes’ chemical structure. This study was aimed at accurately predicting CAD homologous fatty acids under varying experimental conditions. Fatty from C12 to C18 were used as model substances due semivolatile characterics caused non-uniform behaviour. Considering both conditions and molecular descriptors, mixed quantitative structure–property relationship...
The aim of this study was to develop a novel reversed-phase high-performance liquid chromatography (RP-HPLC) method for efficient separation ivabradine and its 11 impurities. Similar polarity impurities in the sample mixture made optimization challenging accomplishable only when different chemometric tools, such as principal component analysis (PCA), Box–Behnken design (BBD), desirability function multicriteria approach, were employed. presence 3 positional isomers (impurities III, V, VI),...
Diabetes mellitus is one of the leading world’s public health problems. Therefore, it a huge interest to develop new antidiabetic drugs. Apart from traditional therapy diabetes, nowadays, importance given natural substances with potential. Fomes fomentarius mushroom widely used for different purposes, due its range already confirmed activities. Fomentariol constituent , responsible In that respect, important method isolation and quantification fomentariol fungal material, which will be...
Abstract Serbia is heavily dependent on expensive imported energy resources (oil, gas, and high-quality coal) that place a big burden the economy. Pollution, related to production consumption, becoming great environmental concern in country. At same time, it estimated has potential produce almost 4 Mtoes per year from renewable sources. It more than half of current primary production. In this regard, appear be one most efficient effective solutions for clean sustainable development. This...
Abstract This paper is aimed at developing a gradient elution reversed-phase high-performance liquid chromatography (RP-HPLC) method for the separation of complex mixture composed ivabradine and its eleven impurities, in reasonable timeframe. In order to obtain robust reliable HPLC this mixture, Analytical Quality by Design (AQbD) was applied. approach demonstrated be useful development long lasting life cycle methods. Four chromatographic variables were defined as key parameters (KMPs)...
Recently, growing interest is devoted to investigation of bioactive secondary metabolites endophytic fungi. Thus, as an extension our previous achievements related antimicrobial potential fungi, Phomopsis species isolated from conifer needles was selected appropriately promising natural source for drug discovery. Its dichloromethane and ethanol extracts considerably inhibited growth Escherichia coli Staphylococcus aureus . Moreover, the individual compounds extract have been separated,...
Recently, growing interest has been devoted to the investigation of compounds with antimicrobial activity due rising cases resistance microbes known therapies. A reliable and versatile source novel drug discovery was recently found among endophytic fungi. Hitherto, research usually enclosed in vitro evaluation chemical structure elucidation biomolecules extracted from fungal material. Therefore, this designed as an extension previous investigations fungi on conifer needles by means...
Cyclodextrins (CDs) are widely used in pharmaceutical analysis due to its biodegradability and eco-friendly character. The particular structure of CDs, characterized by hydrophobic cavity, enables the formation inclusion complexes with variety organic compounds. As structures lacking chromophores, CDs could not be detected Photodiode Array (PDA) detector Corona Charged Aerosol Detector (CAD) was introduced as most appropriate for formed complexes. aim study investigate degree complexation...