Antoine Baldassari
A5039257148- Genetic Associations and Epidemiology
- Air Quality and Health Impacts
- Rheumatoid Arthritis Research and Therapies
- Epigenetics and DNA Methylation
- Cardiac electrophysiology and arrhythmias
- Systemic Lupus Erythematosus Research
- Cardiomyopathy and Myosin Studies
- Autoimmune and Inflammatory Disorders Research
- Blood groups and transfusion
- Health disparities and outcomes
- Adipokines, Inflammation, and Metabolic Diseases
- Health, Environment, Cognitive Aging
- Cancer-related molecular mechanisms research
- Nutrition, Genetics, and Disease
- Birth, Development, and Health
- RNA modifications and cancer
- Global Health Workforce Issues
- Genetic Mapping and Diversity in Plants and Animals
- Genomics and Rare Diseases
- BRCA gene mutations in cancer
- Energy and Environment Impacts
- Hemoglobinopathies and Related Disorders
- Cancer-related gene regulation
- Air Quality Monitoring and Forecasting
- Spondyloarthritis Studies and Treatments
Regeneron (United States)
2023-2025
University of North Carolina at Chapel Hill
2014-2023
DNA methylation (DNAm) may contribute to processes that underlie associations between air pollution and poor health. Therefore, our objective was evaluate DNAm ambient concentrations of particulate matter (PM) ≤2.5, ≤10, 2.5-10 μm in diameter (PM
DNA methylation patterns associated with habitual diet have not been well studied. Diet quality was characterized using a Mediterranean-style score and the Alternative Healthy Eating Index score. We conducted ethnicity-specific trans-ethnic epigenome-wide association analyses for leukocyte-derived at over 400 000 CpGs (cytosine-guanine dinucleotides) in 5 population-based cohorts including 6662 European ancestry, 2702 African 360 Hispanic ancestry participants. For diet-associated identified...
Abstract The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization and repolarization, estimated by QRS duration JT interval, respectively. abnormalities are associated with potentially fatal arrhythmia. Using genome-wide multi-ancestry analyses (>250,000 individuals) we identify 177, 156 121 independent loci for QT, QRS, respectively, including a male-specific X-chromosome locus. gene-based rare-variant methods, associations Mendelian disease...
Abstract The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They independent risk predictors for arrhythmia, but underlying biology is unknown. Using multi-ancestry genome-wide association studies we identify 61 (58 previously unreported) loci angle ( N = 118,780) 11 159,715). Seven out of have not been reported other electrocardiographic measures. Enrichments observed in pathways related to cardiac vascular development, muscle...
Abstract Background Quantitative red blood cell (RBC) traits are highly polygenic clinically relevant traits, with approximately 500 reported GWAS loci. The majority of RBC trait have been performed in European- or East Asian-ancestry populations, despite evidence that rare ancestry-specific variation contributes substantially to heritability. Recently developed combined-phenotype methods which leverage genetic correlation improve statistical power not yet applied these traits. Here we...
Background: Inflammatory effects of ambient particulate matter (PM) air pollution exposures may underlie PM-related increases in cardiovascular disease risk and mortality, although evidence PM-associated leukocytosis is inconsistent largely based on small, cross-sectional, and/or unrepresentative study populations. Objectives: Our objective was to estimate PM–leukocyte associations among U.S. women men the Women's Health Initiative Atherosclerosis Risk Communities (n=165,675). Methods: We...
There is abundant evidence that low socioeconomic status (SES) associated with worse health outcomes among people Rheumatoid Arthritis (RA); however, the influence of disadvantage in early life has yet to be studied within population.Data originated from cross-sectional arm Consortium Evaluation African-Americans (CLEAR II), which recruited RA six sites Southeastern United States. We used linear regression models evaluate associations parental homeownership and educational level at...
Abstract Background Circulating white blood cell and platelet traits are clinically linked to various disease outcomes differ across individuals ancestry groups. Genetic factors play an important role in determining these many loci have been identified. However, most of findings were identified populations European (EA), with African Americans (AA), Hispanics/Latinos (HL), other races/ethnicities being severely underrepresented. Results We performed ancestry-combined ancestry-specific...
To examine cross-sectional baseline data from the Consortium for Longitudinal Evaluation of African Americans with Early Rheumatoid Arthritis registry association between socioeconomic status (SES) clinical and self-report health outcomes.We analyzed on 937 who provided comprehensive sociodemographic in addition to self-reported outcomes. SES measures included educational attainment, homeownership, household income, occupation. Outcomes disease activity, joint damage, autoantibody status,...
Compelling evidence suggests that socioeconomic status (SES) is a determinant of health outcomes among persons with arthritis. SES in early life has likewise been associated various aspects health, but the connection between childhood and people arthritis remains to be investigated. The purpose this study was determine influences current on self-reported disability, depression, physical mental doctor-diagnosed arthritis.Data originated from North Carolina network primary care centers....
Abstract Background Associations of socioeconomic status (SES) with the prevalence various forms arthritis are well documented. Increasing evidence suggests that SES during childhood is a lasting determinant health, but its association onset remains unclear. Methods Cross-sectional data on 1276 participants originated from 22 family practices in North-Carolina, USA. We created 4-level (high, medium, low, lowest) current and summary scores based parental participant education, occupation...
Background: We examined how expanding electrocardiographic trait genome-wide association studies to include ancestrally diverse populations, prioritize more precise phenotypic measures, and evaluate evidence for shared genetic effects enabled the detection characterization of loci. Methods: decomposed 10 seconds, 12-lead electrocardiograms from 34 668 multi-ethnic participants (15% Black; 30% Hispanic/Latino) into 6 contiguous, physiologically distinct (P wave, PR segment, QRS interval, ST T...
Concurrent variation in adiposity and inflammation suggests potential shared functional pathways pleiotropic disease underpinning. Yet, exploration of pleiotropy the context adiposity-inflammation has been scarce, none included self-identified Hispanic/Latino populations. Given high level ancestral diversity Hispanic American population, genetic studies may reveal variants that are infrequent/monomorphic more homogeneous Using multi-trait Adaptive Sum Powered Score (aSPU) method, we examined...
Genome-wide association studies have been successful mapping loci for individual phenotypes, but few comprehensively interrogated evidence of shared genetic effects across multiple phenotypes simultaneously. Statistical methods proposed analyzing using summary statistics, which enables while avoiding challenges associated with individual-level data sharing. Adaptive tests developed to maintain power against alternative hypotheses because the most powerful single-alternative test depends on...