Kristina M. Jordahl
A5014385672- Prostate Cancer Treatment and Research
- Epigenetics and DNA Methylation
- Digestive system and related health
- Air Quality and Health Impacts
- Birth, Development, and Health
- Molecular Biology Techniques and Applications
- Bladder and Urothelial Cancer Treatments
- RNA Research and Splicing
- Nutrition, Genetics, and Disease
- Genetic Associations and Epidemiology
- Cancer-related gene regulation
- Prostate Cancer Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Urinary and Genital Oncology Studies
- Genetic Syndromes and Imprinting
- Health, Environment, Cognitive Aging
- Estrogen and related hormone effects
- Air Quality Monitoring and Forecasting
- BRCA gene mutations in cancer
- Nutritional Studies and Diet
- Cancer-related molecular mechanisms research
- Climate Change and Health Impacts
- Cancer, Lipids, and Metabolism
- Frailty in Older Adults
- HIV-related health complications and treatments
University of Washington
2018-2024
Fred Hutch Cancer Center
2015-2024
Harvard University
2014-2017
Brigham and Women's Hospital
2015
Dana-Farber Cancer Institute
2015
<h3>Importance</h3> Accelerated biological aging is associated with decreased physical capability and cognitive functioning, which are increased risk of morbidity mortality. <h3>Objective</h3> We investigated associations between epigenetic age acceleration (EAA), a biomarker aging, healthy longevity among older women. <h3>Design, Setting, Participants</h3> This cohort study was secondary analysis participants in the Women's Health Initiative (WHI) who were eligible to survive 90 years by...
DNA methylation (DNAm) may contribute to processes that underlie associations between air pollution and poor health. Therefore, our objective was evaluate DNAm ambient concentrations of particulate matter (PM) ≤2.5, ≤10, 2.5-10 μm in diameter (PM
Abstract Purpose: Prostate cancers incite tremendous morbidity upon metastatic growth. We previously identified Asporin (ASPN) as a potential mediator of progression found within the tumor microenvironment. ASPN contains an aspartic acid (D)-repeat domain and germline polymorphisms in D-repeat-length have been associated with degenerative diseases. Associations D risk prostate cancer to disease not assessed. Experimental Design: Germline was retrospectively analyzed 1,600 men who underwent...
Abstract Background Menopausal hormone therapy (MHT), a common treatment to relieve symptoms of menopause, is associated with lower risk colorectal cancer (CRC). To inform CRC prediction and MHT risk-benefit assessment, we aimed evaluate the joint association polygenic score (PRS) for on risk. Methods We used data from 28,486 postmenopausal women (11,519 cases 16,967 controls) European descent. A PRS based 141 CRC-associated genetic variants was modeled as categorical variable in quartiles....
Regular, long-term aspirin use may act synergistically with genetic variants, particularly those in mechanistically relevant pathways, to confer a protective effect on colorectal cancer (CRC) risk. We leveraged pooled data from 52 clinical trial, cohort, and case-control studies that included 30,806 CRC cases 41,861 controls of European ancestry conduct genome-wide interaction scan between regular aspirin/nonsteroidal anti-inflammatory drug (NSAID) imputed variants. After adjusting for...
Abstract Background: The androgen receptor (AR) is an essential gene in prostate cancer pathogenesis and progression. Genetic variation AR exists, including a polymorphic CAG repeat sequence that inversely associated with transcriptional activity. Experimental data suggest heightened activity facilitates formation of TMPRSS2:ERG, fusion present approximately 50% tumors patients cancer. Methods: We undertook nested case–control study to investigate the hypothesis shorter length would be risk...
Background In the United States, half of men with prostate cancer harbor androgen-regulated gene fusion TMPRSS2:ERG. We hypothesized that TMPRSS2:ERG positive tumors are more responsive to androgen deprivation therapy (ADT). Methods studied a cohort 239 from Physicians' Health Study and Professionals Follow-up who received ADT during their disease course. Fusion status was assessed on available tumor tissue by immunohistochemistry for ERG protein expression. used Cox models calculate hazard...
To investigate the role of adiponectin receptor 2 (AdipoR2) in aggressive prostate cancer we used immunohistochemistry to characterize AdipoR2 protein expression tumor tissue for 866 men with from Physicians' Health Study and Professionals Follow-up Study. was not associated measures obesity, pathological stage or prostate-specific antigen (PSA) at diagnosis. However, positively proliferation as measured by Ki-67 quartiles (P-trend < 0.0001), fatty acid synthase = 0.001), two angiogenesis...
Smoking accounts for approximately 52% of bladder cancer incidence among postmenopausal women, but the underlying mechanism is poorly understood. Our study investigates whether changes in DNA methylation, as measured blood, mediate impact smoking on risk women. We conducted analyses 206 cases and 251 controls that were current or never smokers at baseline from a previous case-control genome-wide methylation nested within Women's Health Initiative. Separate mediation three CpG sites...
Genome-wide association studies have identified more than 100 SNPs that increase the risk of prostate cancer (PrCa). We identify and compare expression quantitative trait loci (eQTLs) CpG methylation (meQTLs) among 147 established PrCa in primary tumors (n = 355 from a Seattle-based study n 495 The Cancer Genome Atlas, TCGA) tumor-adjacent, histologically benign samples 471 Mayo Clinic study). role DNA eQTL regulation gene was investigated by data triangulation using several causal inference...
Molecular mechanisms underlying the negative health effects of shift work are poorly understood, which remains a barrier to developing intervention strategies protect long-term workers. We evaluated genome-wide differences in DNA methylation (measured blood) between 111 actively employed female nightshift and 86 dayshift workers from Seattle metropolitan area. also explored effect chronotype (i.e., measure preference for activity earlier or later day) on among 110 an additional group 131...
Background: Inflammatory effects of ambient particulate matter (PM) air pollution exposures may underlie PM-related increases in cardiovascular disease risk and mortality, although evidence PM-associated leukocytosis is inconsistent largely based on small, cross-sectional, and/or unrepresentative study populations. Objectives: Our objective was to estimate PM–leukocyte associations among U.S. women men the Women's Health Initiative Atherosclerosis Risk Communities (n=165,675). Methods: We...
Body mass index (BMI), a well-known risk factor for poor cardiovascular outcomes, is associated with differential DNA methylation (DNAm). Similarly, metabolic health has also been changes in DNAm. It unclear how overall outside of BMI may modify the relationship between and profiles, what consequences this have on downstream disease. The purpose study was to identify cytosine-phosphate-guanine (CpG) sites at which association DNAm could be modified by health.The discovery population derived...
Diabetes is an established risk factor for colorectal cancer. However, the mechanisms underlying this relationship still require investigation and it not known if association modified by genetic variants. To address these questions, we undertook a genome-wide gene-environment interaction analysis.
Abstract Background: Currently known associations between common genetic variants and colorectal cancer explain less than half of its heritability 25%. As alcohol consumption has a J-shape association with risk, nondrinking heavy drinking are both risk factors for cancer. Methods: Individual-level data was pooled from the Colon Cancer Family Registry, Colorectal Transdisciplinary Study, Genetics Epidemiology Consortium to compare nondrinkers (≤1 g/day) drinkers (&gt;28 light-to-moderate...
Colorectal cancer risk can be impacted by genetic, environmental, and lifestyle factors, including diet obesity. Gene-environment interactions (G × E) provide biological insights into the effects of obesity on colorectal risk. Here, we assessed potential genome-wide G E between body mass index (BMI) common SNPs for using data from 36,415 cases 48,451 controls three international consortia (CCFR, CORECT, GECCO). The tests included conventional logistic regression multiplicative terms (one...
Background: Differential DNA methylation as measured in blood is a promising marker of bladder cancer susceptibility. However, previous studies have exclusively used postdiagnostic samples, meaning that observed associations may be markers disease rather than susceptibility.Methods: Genome-wide was prediagnostic using the Illumina Infinium HumanMethylation450 Bead Array, among 440 cases with transitional cell carcinoma (TCC) subtype and matched cancer-free controls from Women's Health...
Abstract Background Epigenetic age acceleration (EAA), a measure of accelerated biological aging, has been associated with an increased risk several age-related chronic conditions. This is the first study to prospectively examine relationship between EAA and both multimorbidity count weighted score among long-lived postmenopausal women. Methods We included 1 951 women from Women’s Health Initiative who could have survived 90. was estimated using Horvath pan-tissue, Hannum, PhenoAge, GrimAge...