A5077184586- Venous Thromboembolism Diagnosis and Management
- Health disparities and outcomes
- Herpesvirus Infections and Treatments
- Atrial Fibrillation Management and Outcomes
- Ocular Oncology and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Pulmonary Hypertension Research and Treatments
- Frailty in Older Adults
- Transportation and Mobility Innovations
- Cardiac Arrhythmias and Treatments
- Cutaneous Melanoma Detection and Management
- Physical Activity and Health
- Health Systems, Economic Evaluations, Quality of Life
- Cytomegalovirus and herpesvirus research
- Retinal Diseases and Treatments
- Bartonella species infections research
- Acute Myocardial Infarction Research
- Statistical Methods in Clinical Trials
- Genital Health and Disease
- Dementia and Cognitive Impairment Research
- Cardiac Imaging and Diagnostics
- Traffic and Road Safety
- Legionella and Acanthamoeba research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Retinal and Macular Surgery
Aetion (United States)
2023-2024
University of California, San Diego
2020-2024
Engineering Information Foundation
2024
Human Longevity (United States)
2021-2022
San Diego State University
2019-2022
Himalayan University
2022
Rai University
2022
People’s University
2020
Massachusetts Eye and Ear Infirmary
2016-2019
Beth Israel Deaconess Medical Center
2016-2017
Human or recombinant apolipoprotein A-I (apoA-I) has been shown to increase high-density lipoprotein-mediated cholesterol efflux capacity and regress atherosclerotic disease in animal clinical studies. CSL112 is an infusible, plasma-derived apoA-I that studied normal subjects those with stable coronary artery disease. This study aimed characterize the safety, tolerability, pharmacokinetics, pharmacodynamics of patients a recent acute myocardial infarction.The AEGIS-I trial (Apo-I Event...
Patients with atrial fibrillation who undergo intracoronary stenting traditionally are treated a vitamin K antagonist (VKA) plus dual antiplatelet therapy (DAPT), yet this treatment leads to high risks of bleeding. We hypothesized that regimen rivaroxaban P2Y12 inhibitor monotherapy or DAPT could reduce bleeding and thereby have favorable impact on all-cause mortality the need for rehospitalization.Stented subjects nonvalvular (n=2124) were randomized 1:1:1 administration reduced-dose 15 mg...
<h3>Importance</h3> Accelerated biological aging is associated with decreased physical capability and cognitive functioning, which are increased risk of morbidity mortality. <h3>Objective</h3> We investigated associations between epigenetic age acceleration (EAA), a biomarker aging, healthy longevity among older women. <h3>Design, Setting, Participants</h3> This cohort study was secondary analysis participants in the Women's Health Initiative (WHI) who were eligible to survive 90 years by...
Stroke is a morbid and potentially mortal complication among patients hospitalized with acute medical illness. The potential of extended-duration thromboprophylaxis the factor Xa inhibitor betrixaban to reduce risk stroke compared standard-dose enoxaparin in this population was assessed retrospective APEX trial substudy (Acute Medically Ill Venous Thromboembolism Prevention With Extended Duration Betrixaban).Hospitalized acutely medically ill subjects (n=7513) were randomized double-dummy...
Background Extended‐duration betrixaban showed a significant reduction in venous thromboembolism the APEX trial (Acute Medically Ill VTE Prevention With Extended Duration Betrixaban Study). Given variable clinical impact of different efficacy and safety events, one approach to assess net outcomes is include only those events that are either fatal or cause irreversible harm. Methods Results This was post hoc analysis trial—a multicenter, double‐blind, randomized controlled comparing...
<h3>Importance</h3> Almost 1 in 4 women older than 65 years is unable to walk 2 3 blocks, and mobility disability a key factor associated with loss of independence. Lack moderate vigorous–intensity physical activity disability, but whether lighter unknown. <h3>Objective</h3> To determine the association light-intensity incident among women. <h3>Design, Setting, Participants</h3> This prospective cohort study included enrolled Objectively Measured Physical Activity Cardiovascular Health...
Abstract Background Self-reported time spent standing has been associated with lower risk of mortality. No previous studies have examined this association using device-measured standing. Method This was a prospective cohort study 5878 older (median age = 80 years), racial/ethnically diverse, community-dwelling women in the WHI Objective Physical Activity and Cardiovascular Health Study (OPACH). Women wore accelerometers for 1 week were followed The applied previously validated machine...
Genital herpes is a common sexually transmitted infection caused by the simplex virus. Contemporary US population-based epidemiologic data on genital are limited. This study aimed to provide nationally representative estimates of prevalence and treatment using large health insurance claims database.
Abstract Background Epigenetic age acceleration (EAA), a measure of accelerated biological aging, has been associated with an increased risk several age-related chronic conditions. This is the first study to prospectively examine relationship between EAA and both multimorbidity count weighted score among long-lived postmenopausal women. Methods We included 1 951 women from Women’s Health Initiative who could have survived 90. was estimated using Horvath pan-tissue, Hannum, PhenoAge, GrimAge...
Objectives. To examine how and what information is communicated via social media during an infectious disease outbreak. Methods. In the context of 2016 through 2018 hepatitis A outbreak in San Diego County, California, we used a grounded theory–based thematic analysis that employed qualitative quantitative approaches to uncover themes sample public tweets (n = 744) from Twitter, primary platform by key stakeholders communicate Results. Tweets contained both general A–specific related...
Despite dual antiplatelet therapy, persistent thrombin generation and thrombin-mediated platelet activation account in part for the residual risk of atherothrombotic disease among patients with prior acute coronary syndrome (ACS). Inhibition high-risk ACS (biomarker-positive ACS) factor Xa inhibitor rivaroxaban may limit ongoing thrombus formation myocardial necrosis thereby improve clinical outcomes.ATLAS 2-TIMI 51 was a double-blind, placebo-controlled trial that randomized to either 2.5...
The purpose of this study was to identify, characterize and compare attitudes, beliefs, behaviors other factors related electronic device (ED) use distracted driving (DD) among taxi app-based drivers.A survey drivers in San Diego across the United States used collect self-reported attitudes passenger-carrying from October 1, 2016 January 31, 2017. Chi-square or Fisher's exact test assess difference between sociodemographics, ED use, citation crash history by driver type. Prevalence ratios...
Summary Competing risk methods are time‐to‐event analyses that account for fatal and/or nonfatal events may potentially alter or prevent a subject from experiencing the primary endpoint. provide more accurate and less biased estimate of incidence an outcome but rarely applied in cardiology trials. APEX investigated efficacy extended‐duration betrixaban versus standard‐duration enoxaparin to composite symptomatic deep‐vein thrombosis (proximal distal), pulmonary embolism, venous...
Social support may be a modifiable risk factor for cognitive impairment. However, few long-term, large prospective studies have examined associations of various forms social with incident mild impairment (MCI) and dementia.
Abstract Background The objective of this study was to estimate the annual incidence rates herpes zoster (HZ) and postherpetic neuralgia (PHN) among individuals aged ≥19 years proportion who received HZ vaccination those ≥50 years. Methods This observational cohort conducted with administrative claims data from HealthVerity included insured across US. Crude US age- sex-standardized PHN were calculated 1 January 2019 31 May 2022 by calendar year in persons Outcomes defined as ≥1 ICD-10...
Abstract By evaluating published emulations of oncology RCTs studies in which both the active and comparator groups are sourced from RWD target trial results available for benchmarking, this systematic review aims to gain insight into factors related emulation performance. Thirteen using various types were identified through an online database search PubMed 2022. Based on ROBINS-I tool, most (N=8) had a serious risk overall bias driven by confounding. Approximately half (N=6) fully proxied...
This cohort study investigates rates of cytomegalovirus testing before and during the COVID-19 pandemic among individuals who were immunocompromised.