A5048249201- Cardiac Imaging and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Cardiac Ischemia and Reperfusion
- Acute Myocardial Infarction Research
- Cardiac Structural Anomalies and Repair
- Lipoproteins and Cardiovascular Health
- Mechanical Circulatory Support Devices
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiac Arrest and Resuscitation
- Takotsubo Cardiomyopathy and Associated Phenomena
- Coronary Interventions and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Vascular Procedures and Complications
- Anesthesia and Neurotoxicity Research
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Issues in Pregnancy
- Adipose Tissue and Metabolism
- Atrial Fibrillation Management and Outcomes
- Atherosclerosis and Cardiovascular Diseases
- Cardiomyopathy and Myosin Studies
- Cardiovascular Disease and Adiposity
- Vector-borne infectious diseases
- Endoplasmic Reticulum Stress and Disease
John Paul II Hospital
2020-2025
Uczelnia Łazarskiego
2022-2025
Western Hospital
2016-2024
Medical University of Warsaw
2016-2024
Assistance Publique – Hôpitaux de Paris
2016
Inserm
2016
Clinical Research Institute
2016
Sorbonne Paris Cité
2016
Université Paris Cité
2016
Hôpital Bichat-Claude-Bernard
2016
Human or recombinant apolipoprotein A-I (apoA-I) has been shown to increase high-density lipoprotein-mediated cholesterol efflux capacity and regress atherosclerotic disease in animal clinical studies. CSL112 is an infusible, plasma-derived apoA-I that studied normal subjects those with stable coronary artery disease. This study aimed characterize the safety, tolerability, pharmacokinetics, pharmacodynamics of patients a recent acute myocardial infarction.The AEGIS-I trial (Apo-I Event...
Epicardial adipose tissue (EAT) is a fat deposit surrounding the heart and located under visceral layer of pericardium. Due to its unique features, contribution EAT pathogenesis cardiovascular metabolic disorders extensively studied. Especially, can be associated with onset development coronary artery disease, myocardial infarction post-infarct failure which all are significant problems for public health. In this article, we focus on mechanisms how impacts acute syndromes. Particular...
Despite significant advances in imaging modalities for diagnosing coronary artery disease (CAD), there remains a need novel diagnostic approaches with high predictive values and fewer limitations. Circulating biomarkers, including cytokines such as interleukin-6 (IL-6) interleukin-8 (IL-8), cell adhesion molecules soluble vascular molecule-1 (sVCAM-1), peptides secreted by endothelial cells endothelin-1 (ET-1), enzymes involved extracellular matrix remodeling disintegrin metalloproteinase...
In this paper, we present 2 patients with ST-elevation myocardial infarction in the course of Spontaneous Coronary Artery Dissection. The first patient, a female admitted STEMI, was diagnosed SCAD intravascular imaging and treated IVUS-guided PCI. second young male hospitalized due to angina not identified initially, patient conservatively. Based on these cases, show different faces same disease that imply diagnostics management strategies. We draw attention fact affects only women without...
The Impella percutaneous mechanical circulatory support device provides improved in treating patients with high-risk coronary interventions (HR-PCI) or cardiogenic shock. IMPELLA-PL is a multicenter registry developed to share clinical data and experiences using technology Poland. retrospective analysis conducted this study aims fill the knowledge gap of performance multivessel artery disease (CAD) depressed left ventricular ejection fraction (EF) (≤30%) treated HR-PCI. Retrospective were...
Late presenters with ST-elevation myocardial infarction pose a considerable challenge in the field of cardiovascular medicine. These individuals, who delay seeking medical attention after onset symptoms, often face substantial difficulties treatment. The coronavirus disease 2019 pandemic led to significant increase number late presenters. By increasing frequency complications such as thromboembolic events course left ventricular thrombus, necessitated refinement existing management...
Impella is a percutaneous mechanical circulatory support device for treatment of cardiogenic shock (CS) and high-risk coronary interventions (HR-PCIs). IMPELLA-PL national retrospective registry Impella-treated CS HR-PCI patients in 20 Polish interventional cardiological centers, conducted from January 2014 until December 2021.
Heart failure (HF) is a complex syndrome characterized by impaired cardiac function. Two common subtypes of HF include heart with preserved ejection fraction (HFpEF) and reduced (HFrEF). In this study, we aimed to evaluate compare the plasma levels 3-nitrotyrosine (3-NT)—as marker nitrosative/oxidative stress myeloperoxidase (MPO)—as an indicator inflammation between HFpEF HFrEF. Twenty-seven patients diagnosed twenty-two HFrEF were enrolled in study. Additionally, forty-one recruited for...
With a growing number of patients on ticagrelor therapy after stent implantation, we observe many cases side effects the drug, mostly dyspnoea and bradycardia. In our article present 2 patients, in which symptoms were particularly severe. Then describe possible mechanisms these complications, explain how to carry out differential diagnosis, discuss when switch other antiplatelet drug finally way deal with symptoms.
Myocardial infarction (MI) significantly contributes to the global mortality rate, often leading heart failure (HF) due left ventricular remodeling. Key factors in pathomechanism of HF include nitrosative/oxidative stress, inflammation, and endoplasmic reticulum (ER) stress. Furthermore, while a high-fat diet (HFD) is known exacerbate post-MI cardiac remodeling, its impact on these critical context not as well understood.
Unfolded Protein Response (UPR), endoplasmic reticulum (ER) stress, and inducible nitric oxide synthase (iNOS) overexpression have been found to influence heart failure with preserved ejection fraction (HFpEF) pathogenesis. Their importance in reduced (HFrEF) is not entirely established; there little data involving a detailed comparison between HFpEF HFrEF from this perspective. This pilot study aimed compare circulating levels of Glucose-regulated protein 78kDa (GRP78) (ER - stress marker)...
Background: Distal transradial access (dTRA) has been proposed as an alternative to traditional (TRA) in cardiac catheterization. Aims: The study aimed compare these two approaches: TRA and dTRA terms of clinical biochemical aspects. Methods: Two hundred patients who qualified for the elective coronary procedure were included. assigned one groups depending on their vascular access. compared perceived pain using Visual Analogue Scale (VAS), time gaining access, need conversion, local...
Objective: Spontaneous coronary artery dissection (SCAD) is one of the causes acute syndrome unknown etiology. Potential risk factors and comorbidities are female gender, fibromuscular dysplasia (FMD) increased tortuosity. HTN associated with tortuosity both have been shown to increase recurrence after SCAD. The aim this study was assess angiographic data clinical course SCAD in patients HTN. Design method: group comprised 94 consecutive (97.8% females, aged 44.4 ± 9.3 years) a history...
Relation of right-to-left shunt (RLS) with chronic hyperventilation syndrome (CHVS) has not been previously reported. We evaluated the prevalence RLS in patients CHVS. Patients CHVS and 25 healthy controls (CG) were recruited into study. Vascular was diagnosed using contrast TCD. Of subjects CHVS, 16 (64%) had vs 3 from CG (12%). TEE confirmed PFO 10 (40%) 2 (8%). Pulmonary AVM found chest CT (10%) none CG. The significantly higher than subjects.
Patients with acute myocardial infarction are at high risk for developing heart failure due to scar development. Although regenerative approaches evolving, consistent clinical benefits have not yet been reported. Treatment dutogliptin, a second-generation DPP-4 inhibitor, in co-administration filgrastim (G-CSF) has shown enhance endogenous repair mechanisms experimental models. The REC-DUT-002 trial was phase 2, multicenter, double-blind placebo-controlled which explored the safety,...