A5077476381- Prostate Cancer Treatment and Research
- Cancer Immunotherapy and Biomarkers
- Molecular Biology Techniques and Applications
- Immunotherapy and Immune Responses
- RNA Research and Splicing
- Connexins and lens biology
- Urological Disorders and Treatments
- S100 Proteins and Annexins
- Transcranial Magnetic Stimulation Studies
- Obstructive Sleep Apnea Research
- Musculoskeletal pain and rehabilitation
- Acute Ischemic Stroke Management
- Cancer-related gene regulation
- Pediatric Urology and Nephrology Studies
- Renal and related cancers
- Prostate Cancer Diagnosis and Treatment
- Neonatal and fetal brain pathology
- Sleep and Wakefulness Research
- Infant Development and Preterm Care
- Neonatal Respiratory Health Research
- RNA and protein synthesis mechanisms
- Alcohol Consumption and Health Effects
- Ubiquitin and proteasome pathways
- Inflammasome and immune disorders
- Neuroscience of respiration and sleep
University of Split
2011-2025
University of Mostar
2025
Johns Hopkins University
2014-2019
Johns Hopkins Medicine
2014-2019
University of Baltimore
2016
Johns Hopkins Hospital
2016
Acute ischemic stroke (AIS) is the world's second leading cause of mortality. An established method for treating patients in acute settings endovascular therapy (EVT). However, correlation successful treatment AIS with presence communicating arteries circle Willis needs to be proven. Our study examined clinical and radiological data 158 consecutive treated mechanical thrombectomy (MT) at our comprehensive center. We analyzed their CT angiograms digital subtraction angiography (DSA) assess...
Cardiac surgery-related acute kidney injury (CS-AKI) is a decrease in function after open-heart surgery, affecting up to 50% of patients. The pathophysiology CS-AKI involves ischemia-reperfusion injury, inflammation, and oxidative stress. Ubiquinone potent antioxidant, we hypothesized that it could both the incidence severity CS-AKI. intervention group received ubiquinone (8 mg/kg/day) divided into three daily doses, while control placebo. primary outcome was CS-AKI, which manifested as an...
As acute ischemic stroke (AIS) is still a significant cause of morbidity globally, new methods rapid diagnostics are continually being researched and improved. Still, the only definite way to diagnose AIS radiological imaging. Lately, serum biomarkers glial fibrillary acidic protein (GFAP) ubiquitin C-terminal hydrolase L1 (UCH-L1) have shown their usefulness in as potential complementary tools early recognition. We aimed investigate if GFAP UCH-L1 can correlate with comprehensive diagnostic...
Abstract Purpose: Prostate cancers incite tremendous morbidity upon metastatic growth. We previously identified Asporin (ASPN) as a potential mediator of progression found within the tumor microenvironment. ASPN contains an aspartic acid (D)-repeat domain and germline polymorphisms in D-repeat-length have been associated with degenerative diseases. Associations D risk prostate cancer to disease not assessed. Experimental Design: Germline was retrospectively analyzed 1,600 men who underwent...
Approximately 60% of patients with squamous cell carcinoma (LSCC) have regional occult metastatic disease/distant metastases at the time diagnosis, putting them higher risk for disease progression. Therefore, biomarkers are needed early prognostic purpose. The aim this study was to analyze expression pattern connexins (Cx) 37, 40 and 45, pannexin1 (Panx1) vimentin in LSCC correlate tumor grade (G) outcome.Thirty-four who underwent (hemi-)laryngectomy lymphadenectomy due from 2017 2018...
We studied the influence of experimentally induced DM1, in combination with different dietary n6:n3 polyunsaturated fatty acid (PUFA) ratios on types nerve fibers rat myocardium, order to reveal whether protective/unfavorable effects PUFAs myocardial function diabetic patients could be a (partial) repercussion their effect changes cardiac innervation. The control group (c) and (stz) were fed an n6/n3 ratio ≈7; diet stz+n6 had ≈60, while for stz+DHA contained 2.5% fish oil (containing 16%...
Numerous evidence corroborates roles of gap junctions/hemichannels in proper kidney development. We analyzed how Dab1 gene functional silencing influences expression and localization Cx37, Cx40, Cx43, Cx45, Panx1 renin postnatal kidneys yotari mice, by using immunohistochemistry electron microscopy. Δ102/221 might lead to the activation c-Src tyrosine kinase, causing upregulation Cx43 medulla mice. The was more prominent mice (p < 0.001). Renin granules were unusually present inside vascular...
Hyperinflammatory response that resembles Kawasaki disease may develop in children after COVID-19 disease, and it is called multisystem inflammatory syndrome children. The cause of MIS-C dysregulated innate immune a subsequent cytokine storm results endothelial damage. It has been determined low levels serum 25(OH)D increase the risk developing immune-related diseases disorders.To determine incidence hypovitaminosis D, possible correlation between clinical severity MIS-C, 21 patients...
We report the establishment of B6CaP, an allograft tumor line from a Hi-Myc transgenic mouse that had been backcrossed onto C57BL/6J background. This grows subcutaneously in wildtype immunocompetent mice, expresses AR, and has luminal cytokeratin profile. When digested into single cells injected via intracardiac injection, B6CaP produces metastatic widespread metastases including frequent bone lesions. Metastatic lesions occur most often femur, spine, skull, have mixed...
Purpose: The aim of this study was to analyze the incidence intrarenal reflux (IRR) among vesicoureteral refluxes (VURs), diagnosed by contrast-enhanced voiding urosonography (ceVUS), define VURs which are positive IRR and their locations in kidney. Materials Methods: Seventy patients with VURs, including 103 uretero-renal units (URUs) grades II–V (37 URUs were excluded because renal anomalies or absence VUR) examined ceVUS due recurrent febrile UTI first accompanied abnormalities on...
Studies of the cardioprotective effects wine are mainly focused on red wines, due to their much higher content bioactive compounds relative white wines. Although some studies indicate a effect wine, there is no clear consensus existence additional benefits over ethanol. The aim this study was determine and compare moderate consumption ethanol survival rats subjected surgically induced myocardial infarction (MI). Male Sprague Dawley (n = 74) were randomized into three groups: water only, or...
AimTo test the association of NOS3 gene with hypoxic-ischemic encephalopathy (HIE).MethodsThe study included 110 unrelated term or preterm born children (69 boys and 41 girls) HIE 128 (60 68 without any neurological problems after second year life. Children perinatal fulfilled diagnostic criteria for asphyxia. All were admitted to Clinical Hospital Split between 1992 2008. We analyzed 6 tagging single nucleotide polymorphisms (SNP) within (rs3918186, rs3918188, rs1800783, rs1808593,...
Neutrophils and monocytes through their CD15s, CD11b CD44 adhesion molecules are implicated in the initiation resolution of cardiac inflammation as well healing processes after myocardial infarction (MI). The aim this study was to determine effect white wine consumption on granulocyte monocyte CD11b, expression 24h surgically inflicted MI. Granulocytes were analyzed by flow cytometry, using whole blood male Sprague–Dawley rats that consumed for 4 weeks. This group compared with water only...
Hip osteoarthritis (HOA) is characterized by degradation of the cartilage and synovitis. However, pathohistological effects synovial tissue inflammation on HOA are not clear. The aim this study was to evaluate expression iNOS, BCL-2 MMP-9 markers in different cell populations. A total 32 patients were evaluated retrospectively. Age, sex, height, weight, body mass index recorded lymphocyte, fibrocytes macrophages analysed sections. Osteoarthritis histopathology assessment system (OARSI),...
This study aimed to explore the spatio-temporal expression patterns of congenital anomalies kidney and urinary tract (CAKUT) candidate genes, Fibroblast Growth Factor Receptor 1 (FGFR1), 2 (FGFR2) Receptor-Interacting Protein Kinase 5 (RIP5), in human fetal development (CTRL) kidneys affected with CAKUT. Human from 22nd 41st developmental week (duplex, hypoplastic, dysplastic, controls) were stained antibodies analyzed by epifluorescence microscopy RT-qPCR. The effect CAKUT genes on...
Introduction . Effects of white wine and the role polyphenols on weight gain in rats different age were examined 4‐week‐voluntary‐consumption trial. Methods Materials Biochemically characterized standard (low polyphenols, W) macerated (high polyphenolic content, PW) wines compared. One‐ three‐month‐old Sprague‐Dawley male ( n = 78) used. Each group was subdivided into water‐only‐drinking controls (C), W, PW‐drinking animals. Daily total liquid consumption, food intake, body measured, energy...
Thyroid volume of Hashimoto's thyroiditis (HT) patients varies in size over the course disease and it may reflect changes biological function thyroid gland. Patients with subclinical hypothyroidism predominantly have increased whereas more pronounced smaller volumes. Suggested mechanism for atrophy is thyrocyte death due to apoptosis. We performed first genome-wide association study (GWAS) two groups HT patients, depending on levothyroxine (LT4) therapy, then meta-analysed across. Study...
Gastric cancer (GC) therapies include gastrectomy and chemoradiotherapy. The tumor immune microenvironment (TME) has implications for potential immunotherapy. We analyzed the expression of PD-L1, CD8, CTLA-4 IFN-γ in regional lymph node (LN) patients with GC compared it clinical pathological data. Paraffin blocks were collected from 97 undergoing gastrectomy/lymphadenectomy GC. Double immunohistochemistry was performed CD8 PD-L1 double immunofluorescence IFN-γ. Statistical significance set...
Our study analyzed the expression pattern of different connexins (Cxs) and renin positive cells in juxtaglomerular apparatus (JGA) developing, postnatal healthy human kidneys nephrotic syndrome Finnish type (CNF), by using double immunofluorescence, electron microscopy statistical measuring. The JGA contained several cell types connected Cxs, consisting macula densa, extraglomerular mesangium (EM) (JC), which release involved renin-angiotensin- aldosteron system (RAS) arterial blood pressure...
Immune thrombocytopenia (ITP) is an acquired autoimmune disorder characterized by isolated defined as platelet count in peripheral blood <100 × 109/L. Hypovitaminosis D very common children with diseases. To analyze whether hypovitaminosis associated the clinical presentation of ITP children, medical records 45 pediatric patients newly diagnosed immune coastal region Croatia were evaluated. The severity bleeding was assessed using two scores. Children lower 25-hydroxyvitamin (25(OH)D) values...