A5075645665- Prostate Cancer Treatment and Research
- Cancer Research and Treatments
- Molecular Biology Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Radiopharmaceutical Chemistry and Applications
- Cancer-related gene regulation
- RNA Research and Splicing
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Pluripotent Stem Cells Research
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Animal Genetics and Reproduction
- Bone and Dental Protein Studies
- Cancer Diagnosis and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Ubiquitin and proteasome pathways
- Estrogen and related hormone effects
- Gut microbiota and health
- Prostate Cancer Diagnosis and Treatment
- Bone health and treatments
- Bladder and Urothelial Cancer Treatments
- Amino Acid Enzymes and Metabolism
University of Baltimore
2010-2024
Johns Hopkins University
2013-2024
Baylor College of Medicine
2013-2024
Fermi National Accelerator Laboratory
2023
Northern Illinois University
2023
Baylor University
2022-2023
Boston University
2023
Texas Children's Hospital
2022
Johns Hopkins Medicine
2011-2020
Sidney Kimmel Comprehensive Cancer Center
2010-2017
Mucoadhesive particles (MAP) have been widely explored for pulmonary drug delivery because of their perceived benefits in improving particle residence the lungs. However, retention adhesively trapped airway mucus may be limited by physiologic clearance mechanisms. In contrast, that avoid mucoadhesion and diameters smaller than mesh spacings rapidly penetrate layers [mucus-penetrating (MPP)], which we hypothesized would provide prolonged lung compared to MAP. We vivo behaviors variously...
Animal models, particularly mouse play a central role in the study of etiology, prevention, and treatment human prostate cancer. While tissue culture models are extremely useful understanding biology cancer, they cannot recapitulate complex cellular interactions within tumor microenvironment that key cancer initiation progression. The National Cancer Institute (NCI) Mouse Models Human Cancers Consortium convened group veterinary pathologists to review current animal make recommendations...
Systemic exposure to nanoparticles induces immune responses that lead anticancer activation.
TWIST1 is a transcription factor critical for development that can promote prostate cancer metastasis. During embryonic development, and HOXA9 are coexpressed in mouse then silenced postnatally. Here we report coexpression reactivated human primary tumors further enriched metastases, correlating with survival. formed complex WDR5 the lncRNA Hottip/HOTTIP, members of MLL/COMPASS-like H3K4 methylases, which regulate chromatin Hox/HOX cluster during development. overexpression led to...
Local delivery of chemotherapeutics in the cervicovaginal tract using nanoparticles may reduce adverse side effects associated with systemic chemotherapy, while improving outcomes for early-stage cervical cancer. It is hypothesized here that drug-loaded rapidly penetrate mucus (CVM) lining female reproductive will more effectively deliver their payload to underlying diseased tissues a uniform and sustained manner compared do not efficiently CVM. Paclitaxel-loaded are developed, composed...
Abstract Inflammation is associated with several diseases of the prostate including benign enlargement and cancer, but a causal relationship has not been established. Our objective was to characterize inflammatory microenvironment after infection human prostate‐derived bacterial strain determine effect inflammation on cancer progression. To this end, we mimicked typical retrograde urethral instillation CP1 , prostatic isolate Escherichia coli . bacteria were tropic for accessory sex glands...
Mutant KRAS drives glycolytic flux in lung cancer, potentially impacting aberrant protein glycosylation. Recent evidence suggests of glucose into the hexosamine biosynthetic pathway (HBP). HBP is required for various glycosylation processes, such as N- or O-glycosylation and glycolipid synthesis. However, its function during tumorigenesis poorly understood. One contributor proposed target KRAS-driven cancers a developmentally conserved epithelial plasticity program called...
Tumor progression to metastasis is not cancer cell autonomous, but rather involves the interplay of multiple types within tumor microenvironment. Here we identify asporin (ASPN) as a novel, secreted mesenchymal stromal (MSC) factor in microenvironment that regulates metastatic development. MSCs expressed high levels ASPN, which decreased following lineage differentiation. ASPN loss impaired MSC self-renewal and promoted terminal Mechanistically, bound BMP-4 restricted BMP-4-induced...
The ability to induce pluripotent stem cells from committed, somatic human provides tremendous potential for regenerative medicine. However, there is a defined neoplastic inherent such reprogramming that must be understood and may provide model understanding key events in tumorigenesis. Using genome-wide assays, we identify cancer-related epigenetic abnormalities arise early during persist induced cell (iPS) clones. These include hundreds of abnormal gene silencing events, patterns aberrant...
Prostate cancer is the second leading cause of death among United States men. However, disease aggressiveness varied, with low-grade often being indolent and high-grade accounting for greatest density deaths. Outcomes are also disparate men prostate cancer, upwards 65% having recurrence even after primary treatment. Identification at risk elucidation molecular processes that drive their paramount, as these most likely to benefit from multimodal therapy. We previously showed androgen-induced...
Zhenhua Huang 1,2,3 , Paula J Hurley 1 Brian W Simons Luigi Marchionni 2,3 David M Berman Ashley E Ross and Edward Schaeffer Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD, USA. 2 Pathology, 3 Oncology, Received: June 26, 2012; Accepted: 30, Published: July 2, Keywords: Sox9, prostate, development, cancer, initiation Correspondence: Schaeffer, email: // Abstract Prostate cancer is one the most common malignancies second leading cause death from in men. The molecular...
Purpose: Enhancing immune responses in triple negative breast cancers (TNBCs) remains a challenge. Our study aimed to determine whether magnetic iron oxide nanoparticle (MION) hyperthermia (HT) can enhance abscopal effects with radiotherapy (RT) and checkpoint inhibitors (IT) metastatic TNBC model.Methods: One week after implanting 4T1-luc cells into the mammary glands of BALB/c mice, tumors were treated RT (3 × 8 Gy)±local HT, mild (HTM, 43 °C/20 min) or partially ablative (HTAbl, 45 °C/5...
Androgen receptor (
Background C-type lectin-like molecule 1 (CLL-1) is highly expressed in acute myeloid leukemia (AML) but absent primitive hematopoietic progenitors, making it an attractive target for a chimeric antigen receptor (CAR) T-cell therapy. Here, we optimized our CLL-1 CAR anti-leukemic activity mouse xenograft models of aggressive AML. Methods First, the using different spacer, transmembrane and costimulatory sequences. We used second retroviral vector to coexpress transgenic IL15. measured...
A defining hallmark of primary and metastatic cancers is the migration invasion malignant cells. These invasive properties involve altered dynamics cytoskeleton one its major structural components β-actin. Here we identify AIM1 (absent in melanoma 1) as an actin-binding protein that suppresses pro-invasive benign prostate epithelium. Depletion epithelial cells increases cytoskeletal remodeling, intracellular traction forces, cell invasion, anchorage-independent growth. In addition, decreased...