A5050521714- Pancreatic function and diabetes
- Nanoparticle-Based Drug Delivery
- Tissue Engineering and Regenerative Medicine
- Nanoplatforms for cancer theranostics
- Insect and Pesticide Research
- Bee Products Chemical Analysis
- Hydrogels: synthesis, properties, applications
- Immune cells in cancer
- Spectroscopy Techniques in Biomedical and Chemical Research
- Advanced biosensing and bioanalysis techniques
- Cancer Immunotherapy and Biomarkers
- Bone Tissue Engineering Materials
- Plant and animal studies
- Immunotherapy and Immune Responses
- Nanoparticles: synthesis and applications
- Surgical Sutures and Adhesives
- SARS-CoV-2 and COVID-19 Research
- Advanced Sensor and Energy Harvesting Materials
- biodegradable polymer synthesis and properties
- Immune Cell Function and Interaction
- Ultrasound and Hyperthermia Applications
- Insect and Arachnid Ecology and Behavior
- Electrospun Nanofibers in Biomedical Applications
- Diabetes Management and Research
- Diabetes and associated disorders
Cornell University
2020-2025
University at Buffalo, State University of New York
2018-2021
Johns Hopkins University
2019-2020
Johns Hopkins Medicine
2019-2020
Systemic exposure to nanoparticles induces immune responses that lead anticancer activation.
Metabolic reprogramming of the tumor microenvironment (TME) and poor immunogenicity are two challenges that cancer immunotherapies have to overcome for improved clinical benefits. Among various immunosuppressive metabolites keep anti-tumor immunity in check, tryptophan catabolite kynurenine (Kyn) is an attractive target blockade given its role mediating immunosuppression through multiple pathways. Here, we present a local chemo-immunometabolic therapy injection supramolecular hydrogel...
Adhesive hydrogels have been recently proposed as a potential option to seal and treat gastric perforation (GP) which causes high mortality despite advancements in surgical treatments. However, be effective, the must sufficient tissue adhesiveness, tough mechanical property, tunable biodegradability ideally are easy apply form. Herein, we report an adhesive resilient hydrogel for sealing treatment of perforation. The consists bioactive, transglutaminase (TG)-crosslinked gelatin network...
Abstract Encapsulation and transplantation of insulin‐producing cells offer a promising curative treatment for type 1 diabetes (T1D) without immunosuppression. However, biomaterials used to encapsulate often elicit foreign body responses, leading cellular overgrowth deposition fibrotic tissue, which in turn diminishes mass transfer from transplanted cells. Meanwhile, the encapsulation device must be safe, scalable, ideally retrievable meet clinical requirements. Here, durable safe...
Abstract Automated delivery of insulin based on continuous glucose monitoring is revolutionizing the way insulin‐dependent diabetes treated. However, challenges remain for widespread adoption these systems, including requirement a separate sensor, sophisticated electronics and algorithms, need significant user input to operate costly therapies. Herein, user‐centric glucose‐responsive cannula reported electronics‐free delivery. The cannula—made from tough, elastomer‐hydrogel hybrid membrane...
Biomaterials are widely used for applications that benefit human health and can improve quality of life. However, research in applying biomaterials to areas outside health, such as their use plants agriculture, is also prominent. Bees have a crucial role pollination, but they facing declines due factors disease, climate change, pesticide usage. Here, I discuss the roles bees agricultural sustainability, impacts pesticides on bees, how biomaterial-based strategies be bee after exposure....
Abstract The receptor binding domain (RBD) of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) spike protein that mediates viral entry into host cells is a good candidate immunogen for vaccine development against disease 2019 (COVID‐19). Because its small size, most preclinical and early clinical efforts have focused on multimerizing RBD various formats nanoparticles to increase immunogenicity. Using an easily administered injectable hydrogel scaffold rationally designed enhanced...
Purpose: A proposed mechanism for the enhanced effectiveness of hyperthermia and doxorubicin (Dox) combinations is increased intracellular Dox concentrations resulting from heat-induced cell stress. The purpose this study was to determine whether specific varied heat produce measurable effects greater than additive combination, these can be attributed increases in concentrations.Methods: HCT116, HT29 CT26 cells were exposed water bath heating independently. clonogenic survival assay used...
Zwitterionic cross-linked biodegradable nanocapsules (NCs) were synthesized for cancer imaging. A polylactide (PLA)-based diblock copolymer with two blocks carrying acetylenyl and allyl groups respectively was by ring-opening polymerization (ROP). Azide–alkyne "click" reaction conducted to conjugate sulfobetaine (SB) zwitterions fluorescent dye Cy5.5 onto the acetylenyl-functionalized first block of copolymer. The resulting a hydrophilic SB/Cy5.5-functionalized PLA hydrophobic...
Biodegradable elastomers are important emerging biomaterials for biomedical applications, particularly in the area of soft-tissue engineering which scaffolds need to match physicochemical properties native tissues. Here, we report novel fast photocurable with readily tunable mechanical properties, surface wettability, and degradability. These prepared by a 5-min UV-irradiation thiol-ene reaction systems glycerol tripentenoate (GTP; triene) or combination GTP 4-pentenyl 4-pentenoate (PP;...
The worldwide prevalence of type 1 diabetes motivates the development different treatment options for disease. Current clinical treatments typically require patient involvement, often resulting in stress or inconvenience to due frequent blood glucose measurements and insulin injections infusions. Islet transplantation, a potentially curative treatment, is limited by donor availability need long-term administration immunosuppressants. Cell encapsulation may prevent graft rejection without...