A5100442289- Pancreatic function and diabetes
- Tissue Engineering and Regenerative Medicine
- Pluripotent Stem Cells Research
- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Diabetes Management and Research
- Cancer Cells and Metastasis
- Diabetes and associated disorders
- Immune cells in cancer
- Ion channel regulation and function
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Cannabis and Cannabinoid Research
- Calcium signaling and nucleotide metabolism
- Immune Cell Function and Interaction
- CRISPR and Genetic Engineering
- Proteoglycans and glycosaminoglycans research
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Mesenchymal stem cell research
- PI3K/AKT/mTOR signaling in cancer
- Angiogenesis and VEGF in Cancer
- Glycosylation and Glycoproteins Research
- Cancer-related molecular mechanisms research
- Metabolism, Diabetes, and Cancer
Peking University
2015-2025
Shandong University
2025
Peking University Third Hospital
2023-2025
Tianjin Medical University
2025
Second Hospital of Tianjin Medical University
2025
Peking University First Hospital
2024
Cornell University
2014-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2024
Shenzhen MSU-BIT University
2024
Zunyi Medical University
2024
Although bladder cancer represents a serious health problem worldwide, relevant mouse models for investigating disease progression or therapeutic targets have been lacking. We show that combined deletion of p53 and Pten in epithelium leads to invasive novel model. Inactivation PTEN promotes tumorigenesis human cells is correlated with poor survival tumors. Furthermore, the synergistic effects are mediated by deregulation mammalian target rapamycin (mTOR) signaling, consistent ability block...
Abstract Hydrogels with adhesive properties have potential for numerous biomedical applications. Here, the design of a novel, intrinsically hydrogel and its use in developing internal therapeutic bandages is reported. The involves incorporation “triple hydrogen bonding clusters” (THBCs) as side groups into matrix. THBC through unique “load sharing” effect an increase bond density results strong adhesions to range surfaces, including glass, plastic, wood, poly(tetrafluoroethylene) (PTFE),...
Foreign body reaction (FBR) to implanted biomaterials and medical devices is common can compromise the function of implants or cause complications. For example, in cell encapsulation, cellular overgrowth (CO) fibrosis around constructs reduce mass transfer oxygen, nutrients metabolic wastes, undermining leading transplant failure. Therefore, materials that mitigate FBR CO will have broad applications biomedicine. Here we report a group zwitterionic, sulfobetaine (SB) carboxybetaine (CB)...
Transplantation of stem cell-derived β (SC-β) cells represents a promising therapy for type 1 diabetes (T1D). However, the delivery, maintenance, and retrieval these remain challenge. Here, we report design safe functional device composed highly porous, durable nanofibrous skin an immunoprotective hydrogel core. The consists electrospun medical-grade thermoplastic silicone-polycarbonate-urethane is soft but tough (~15 megapascal at rupture strain >2). Tuning nanofiber size to less than ~500...
Immunological protection of transplanted stem cell-derived islet (SC-islet) cells is yet to be achieved without chronic immunosuppression or encapsulation. Existing genetic engineering approaches produce immune-evasive SC-islet have so far shown variable results. Here, we show that targeting human leukocyte antigens (HLAs) and PD-L1 alone does not sufficiently protect from xenograft (xeno)- allograft (allo)-rejection. As an addition these approaches, genetically engineer secrete the...
Abstract Background A refractory wound is a typical complication of diabetes and common outcome after surgery. Current approaches have difficulty in improving healing. Recently, non-expanded stromal vascular fraction (SVF), which derived from mature fat, has opened up new directions for the treatment The aim current study to systematically investigate impact SVF on healing, including rate characteristics ability fibroblasts migrate, blood transport reconstruction, with special emphasis their...
Temporal activation of ETV2 enables robust differentiation human pluripotent stem cells into competent endothelial cells.
Abstract The success of engineered cell or tissue implants is dependent on vascular regeneration to meet adequate metabolic requirements. However, development a broadly applicable strategy for stable and functional vascularization has remained challenging. We report here highly organized resilient microvascular meshes fabricated through controllable anchored self-assembly method. are scalable centimeters, almost free defects transferrable diverse substrates, ready transplantation. They...
A cell encapsulation system generates oxygen from carbon dioxide for self-oxygenation.
Encapsulation of insulin-producing cells is a promising strategy for treatment type 1 diabetes. However, engineering an encapsulation device that both safe (i.e., no cell escape and breakage) functional low foreign-body response (FBR) high mass transfer) remains challenge. Here, family zwitterionic polyurethanes (ZPU) with sulfobetaine groups in the polymer backbone developed, which are fabricated into devices tunable nanoporous structures via electrospinning. The ZPU hydrophilic...
Metabolic reprogramming of the tumor microenvironment (TME) and poor immunogenicity are two challenges that cancer immunotherapies have to overcome for improved clinical benefits. Among various immunosuppressive metabolites keep anti-tumor immunity in check, tryptophan catabolite kynurenine (Kyn) is an attractive target blockade given its role mediating immunosuppression through multiple pathways. Here, we present a local chemo-immunometabolic therapy injection supramolecular hydrogel...
Monitoring the appearance and progression of tumors are important for improving survival rate patients with ovarian cancer. This study aims to examine circulating tumor cells (CTCs) in epithelial cancer (EOC) evaluate their clinical significance comparison existing biomarker CA125.Immuomagnetic bead screening, targeting antigens on cells, combined multiplex reverse transcriptase-polymerase chain reaction (Multiplex RT-PCR) was used detect CTCs 211 samples peripheral blood (5 ml) from 109 EOC...
Background/Aims: The incidence of gastric cancer (GC) ranks fifth among common tumors and GC is the third leading cause cancer-related death worldwide.The aim this study was to develop validate a nomogram for predicting overall survival (OS) patients with GC.Methods: DNA methylation (DNAm)-driven genes were identified by integrating DNAm gene expression profiling analyses from Cancer Genome Atlas (TCGA) cohort.Then, risk score model built based on Kaplan-Meier (K-M), least absolute shrinkage...
Adhesive hydrogels have been recently proposed as a potential option to seal and treat gastric perforation (GP) which causes high mortality despite advancements in surgical treatments. However, be effective, the must sufficient tissue adhesiveness, tough mechanical property, tunable biodegradability ideally are easy apply form. Herein, we report an adhesive resilient hydrogel for sealing treatment of perforation. The consists bioactive, transglutaminase (TG)-crosslinked gelatin network...
Islet transplantation has been established as a viable treatment modality for type 1 diabetes. However, the side effects of systemic immunosuppression required patients often outweigh its benefits. Here, we engineer programmed death ligand-1 and cytotoxic T lymphocyte antigen 4 immunoglobulin fusion protein–modified mesenchymal stromal cells (MSCs) accessory islet cotransplantation. The engineered MSCs (eMSCs) improved outcome both syngeneic allogeneic in diabetic mice resulted allograft...
A microwell-patterned membranous scaffold that integrates nano- and microscale topographical characteristics based on polyurethane is fabricated for transplanting syngeneic islets allogeneic mesenchymal stem cells into diabetic rodents. The effectively allows assembling of single cells/microtissues, enables the transplantation with spatial control, improves transplant's engraftment efficacy in vivo treating diabetes.