A5032728056- Venous Thromboembolism Diagnosis and Management
- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Cancer Immunotherapy and Biomarkers
- Diagnosis and Treatment of Venous Diseases
- Atrial Fibrillation Management and Outcomes
- Cancer, Stress, Anesthesia, and Immune Response
- Prostate Cancer Treatment and Research
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Epigenetics and DNA Methylation
- Peripheral Artery Disease Management
- Health Systems, Economic Evaluations, Quality of Life
- Intracerebral and Subarachnoid Hemorrhage Research
- Immunotherapy and Immune Responses
- Poisoning and overdose treatments
- Central Venous Catheters and Hemodialysis
- Clinical practice guidelines implementation
- Muscle and Compartmental Disorders
- Vascular anomalies and interventions
- Lymphoma Diagnosis and Treatment
- BRCA gene mutations in cancer
- Lung Cancer Treatments and Mutations
- Pericarditis and Cardiac Tamponade
CURE International UK
2024
Alberta Hospital Edmonton
2012-2023
Johns Hopkins University
2019-2023
University of Baltimore
2019-2022
Johns Hopkins Medicine
2019-2021
Northwestern Memorial Hospital
2019
Rosalind Franklin University of Medicine and Science
2019
UPMC Hillman Cancer Center
2018
Prince Charles Hospital
2003-2009
Prince Philip Hospital
1986
Tumor-associated macrophages (TAMs) are an abundant tumor-promoting cell type in the tumor microenvironment (TME). Most TAMs exhibit a pro-tumor M2-like phenotype supportive of growth, immune evasion, and metastasis. IL-4 IL-13 major cytokines that polarize to M2 subset share common receptor, receptor alpha (IL-4R alpha). Treatment human ex vivo polarized macrophage precursors with IL-4R antagonist antibody Dupilumab (DupixentⓇ) reduces features, including shift surface marker protein...
Many aspects of cancer can be explained utilizing well-defined ecological principles. Applying these principles to cancer, cells are an invasive species a healthy organ ecosystem. In their capacity as ecosystem engineers, release cytokines that recruit monocytes the tumor and polarize them M2-like protumor macrophages. Macrophages, recruited by cells, act secondary species. The engineering functions M2-macrophages in turn support stimulate cell survival proliferation. cooperative both...
Abstract Background Tumor‐associated macrophages (TAMs) are critical components of the tumor microenvironment (TME) in prostate cancer. Commonly used orthotopic models do not accurately reflect complete TME a human patient or natural initiation and progression tumor. Therefore, genetically engineered mouse essential for studying as well advancing TAM‐targeted therapies. Two common transgenic (TG) cancer Hi‐Myc adenocarcinoma (TRAMP), but TAM characteristics these have been characterized....
Purpose of review This aims to highlight recent advances in prostate cancer tumor-immune microenvironment research and summarize the state-of-the-art knowledge immune checkpoint inhibitors cancer. Recent findings Immune are cornerstone modern immunotherapy which have shown encouraging results across a spectrum cancers. However, only limited survival benefit has been seen patients with Prostate progression its response immunotherapies strongly influenced by microenvironment, whose feature can...
The prostate cancer tumor microenvironment (TME) is comprised of many cell types that can contribute to and influence progression. Some the most abundant TME cells are macrophages, which be modeled on a continuous spectrum M1-like (anti-tumor macrophages) M2-like (pro-tumor macrophages). A function macrophages efferocytosis, phagocytosis apoptotic cells. Based literature from other models contexts, efferocytosis further supports macrophage phenotype. MerTK receptor tyrosine kinase mediates...
Abstract. Biswas M, Prakash PK, Cossburn Myers K, Hanna F. Life‐threatening thrombotic complications of relative polycythaemia (Case Report). J Intern Med 2003; 253: 481–483. Relative refers to raised haematocrit with normal red cell mass. Plasma volume may be reduced. This condition is associated acute hypoxia, smoking, alcohol and diuretics. We describe two life‐threatening events in patients under age 40 years. The first had myocardial infarction on admission haemoglobin was 21.6 g dL −1...
Cancers exploit coinhibitory receptors on T cells to escape tumor immunity, and targeting such mechanisms has shown remarkable clinical benefit, but in a limited subset of patients. We hypothesized that cancer mimic noncanonical early development as axon guidance pathways evade cell immunity. Using gain-of-function genetic screens, we profiled proteins human their cognate ligands identified fibronectin leucine-rich transmembrane protein 3 (FLRT3) ligand inhibits activity. demonstrated FLRT3...
Abstract Our understanding of molecular cell-surface interactions that control T cell responses in cancer remains limited despite many advances the field. We hypothesized tumor cells take advantage developmental protein-protein such as axon guidance could inhibit or repel tumor-immune TME to evade anti-tumor immunity. used gain-of-function screening evaluate a gene-set proteins for inhibitory function human and identified validated Fibronectin Leucine-Rich Transmembrane protein-3 (FLRT3) an...
Management of right ventricular outflow tract obstructive (RVOTO) lesions requires precise quantification pulmonary artery (PA) size. Various cardiovascular magnetic resonance (CMR) sequences are available to assess PA This study aimed determine which CMR correlated best with cardiac catheterization and surgical measurements branch size in children. Forty children RVOTO biventricular circulation underwent prior either or surgery within 6 months. Maximal stenosis (if present) diameter were...
Natural killer (NK) cell lymphocytosis usually has an indolent course and can progress into massive with development of cytopenias neoplastic diseases. NK-cells express one or more "NK-associated" antigens (CD16, CD56, CD57). Reactive expansions are seen in autoimmune diseases, viral infections, solid tumours non-Hodgkin's lymphoma.We report a lady benign clinical over 10 years persistent CD8+/CD3-/CD57+/CD16+ LGL proliferation presence Howell-Jolly bodies (functional hyposplenism),...