A5018139036- Migration and Labor Dynamics
- Migration, Ethnicity, and Economy
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Labor Movements and Unions
- Employment and Welfare Studies
- Prostate Cancer Treatment and Research
- Cytokine Signaling Pathways and Interactions
- Migration, Refugees, and Integration
- Global trade and economics
- Lung Cancer Research Studies
- Agricultural Economics and Policy
- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Ovarian cancer diagnosis and treatment
- Agriculture and Rural Development Research
- Tuberculosis Research and Epidemiology
- Agriculture and Farm Safety
- Agricultural Innovations and Practices
- Molecular Biology Techniques and Applications
- International Labor and Employment Law
- Economic Zones and Regional Development
- Rural development and sustainability
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
University of California Division of Agriculture and Natural Resources
2024
AstraZeneca (Japan)
2024
University of California, Davis
2013-2023
AstraZeneca (United States)
2012-2023
AstraZeneca (United Kingdom)
2023
Ingham Institute
2022-2023
University of Wollongong
2022
Stanford University
2006-2022
University of Manchester
2022
Center for Translational Molecular Medicine
2022
1. Introduction: Myths and Movements 2. Theories Approaches 3. Systems Boundaries 4. The Old Core 5. New 6. Extensions Potential Cores 7. Labour Frontier 8. Resource Niche 9. Conclusion: System the Future
This paper examines the relationship between number and rights of low-skilled migrant workers in high-income countries. It identifies a trade-off: Countries with large numbers offer them relatively few rights, while smaller migrants are typically associated more rights. We discuss number-vs.-rights trade-off theory practice as an example competing goods, raising question whether or should get higher priority. There is no easy universal answer, but avoiding explicit discussion issue – has...
Animal models, particularly mouse play a central role in the study of etiology, prevention, and treatment human prostate cancer. While tissue culture models are extremely useful understanding biology cancer, they cannot recapitulate complex cellular interactions within tumor microenvironment that key cancer initiation progression. The National Cancer Institute (NCI) Mouse Models Human Cancers Consortium convened group veterinary pathologists to review current animal make recommendations...
While immune checkpoint inhibitors such as anti-PD-L1 are rapidly becoming the standard of care in treatment many cancers, only a subset treated patients have long-term responses. IL12 promotes antitumor immunity mouse models; however, systemic recombinant had significant toxicity and limited efficacy early clinical trials.We therefore designed novel intratumoral mRNA therapy to promote local tumor production while mitigating effects.A single dose (m)IL12 induced IFNγ CD8+ T-cell-dependent...
Treatment with anti–PD-1 and anti-PD-L1 therapies has shown durable clinical benefit in non–small cell lung cancer (NSCLC). However, patients NSCLC epidermal growth factor receptor (EGFR) mutations do not respond as well to treatment without an EGFR mutation. We show that EGFR-mutated expressed higher levels of CD73 compared WT tumors expression was regulated by signaling. lines were significantly more resistant T killing through suppression proliferation function. In a xenograft mouse model...
Abstract Background CD73 upregulation in tumors leads to local immunosuppression. This phase I, first-in-human study evaluated oleclumab (MEDI9447), an anti-CD73 human IgG1λ monoclonal antibody, alone or with durvalumab patients advanced colorectal cancer (CRC), pancreatic ductal adenocarcinoma (PDAC), epidermal growth factor receptor-mutant non-small-cell lung (NSCLC). Methods Patients received 5–40 mg/kg (dose-escalation) 40 (dose-expansion) intravenously every 2 weeks (Q2W), (escalation...
California's agricultural employers hired an average of 413,000 workers between 2018 and 2021 reported 882,000 farmworkers during these years, a ratio 2.1 for each job. Average employment has been relatively stable since 2000, while the number by declined. Despite concerns about farm labor shortages, data show pool farmworkers, including rising share who are brought to farms contractors.
The third edition of this major work provides a systematic, comparative assessment the efforts selection countries, including U.S., to deal with immigration and immigrant issues- paying particular attention ever-widening gap between their migration policy goals outcomes. Retaining its comprehensive coverage nations built by immigrants those more recent history immigration, new pays tensions created post-colonial explores how countries have attempted control entry employment legal illegal...
Epithelial-mesenchymal transition (EMT) is implicated in various pathological processes within the prostate, including benign prostate hyperplasia (BPH) and cancer progression. However, an ordered sequence of signaling events initiating carcinoma-associated EMT has not been established. In a model transforming growth factor β (TGFβ)-induced prostatic EMT, SLUG dominant regulator initiation vitro vivo, as demonstrated by inhibition following Slug depletion. contrast, SNAIL depletion was...
ABSTRACT Experiments are reported concerning an evaluation of sympathetic influences on heart rate and cardiac contractility in normal young adult humans during a stressful reaction time task. During the preparatory interval only vagal change could be found which were related to concomitant somatic activity. In expectation shock for more sustained period thereafter, became manifested both independent follow‐up study, relationship was evaluated between blood pressure, as measured directly...
Tumor cells initiate platelet activation leading to the secretion of bioactive molecules, which promote metastasis. Platelet receptors on tumors have not been well-characterized, resulting in a critical gap knowledge concerning platelet-promoted We identify direct interaction between platelets and tumor CD97 that stimulates rapid bidirectional signaling. CD97, an adhesion G protein-coupled receptor (GPCR), is overexpressed antigen several cancer types. Purified extracellular domain or...
In 2009, a novel H1N1 influenza (pH1N1) virus caused the first pandemic in 40 y. The was identified as triple reassortant between avian, swine, and human viruses, highlighting importance of reassortment generation viruses with potential. Previously, we showed that composed wild-type avian H9N2 surface genes seasonal H3N2 backbone could gain efficient respiratory droplet transmission ferret model. Here determine ability context internal pH1N1 to efficiently transmit via droplets ferrets. We...
Abstract The majority of human high-grade serous epithelial ovarian cancer (SEOC) is characterized by frequent mutations in p53 and alterations the RB FOXM1 pathways. A subset SEOC harbors a combination germline somatic as well epigenetic dysfunction for BRCA1/2. Using Cre-conditional alleles intrabursal induction Cre-expressing adenovirus genetically engineered mice, we analyzed roles pathway perturbations initiation progression. Inactivation RB-mediated tumor suppression induced surface...
// Yuan Yang 1,* , Howard H. 2,* Ying Hu 2 Peter Watson 3 Huaitian Liu Thomas R. Geiger 1 Miriam Anver 4 Diana C. Haines Philip Martin Jeffrey E. Green Maxwell P. Lee Kent W. Hunter and Lalage M. Wakefield Lab of Cancer Biology Genetics, Center for Research, National Institute, Bethesda, MD, USA High Dimension Data Analysis Group, British Columbia Agency, Vancouver Island Center, Victoria, Columbia, Canada Pathology Histotechnology Lab, Leidos Biomedical Research Inc., Frederick Laboratory *...
Immunogenic cell death (ICD) is the process by which certain cytotoxic drugs induce apoptosis of tumor cells in a manner that stimulates immune system. In this study, we investigated whether antibody-drug conjugates (ADCS) conjugated with pyrrolobenzodiazepine dimer (PBD) or tubulysin payloads ICD, modulate microenvironment, and could combine immuno-oncology to enhance antitumor activity. We show these on their own induced an response prevented growth tumors following subsequent challenge....
<h3>Background</h3> Immuno-oncology and cancer immunotherapies are areas of intense research. The numbers locations CD8+ tumor-infiltrating lymphocytes (TILs) important measures the immune response to with prognostic, pharmacodynamic, predictive potential. We describe development, validation, application advanced image analysis methods characterize multiple immunohistochemistry-derived CD8 parameters in clinical nonclinical tumor tissues. <h3>Methods</h3> Commercial resection tumors from...
Mutations in the STK11 (LKB1) gene regulate resistance to PD-1/PD-L1 blockade. This study evaluated this association patients with nonsquamous non-small cell lung cancer (NSCLC) enrolled three phase I/II trials. mutations were associated anti-PD-L1 antibody durvalumab (alone/with anti-CTLA4 tremelimumab) independently of KRAS mutational status, highlighting as a potential driver checkpoint Retrospective assessments tumor tissue, whole blood, and serum revealed unique immune phenotype...
Foreword by Diego C. Asencio Introduction Conceptual and Theoretical Issues in International Labor Migration Development: Research Policy Demetrios G. Papademetriou Philip L. Martin Migration: Theory Reality Development Africa Binational Communities Circulation Sub-Saharan Aderanti Adepoju Southern Timothy T. Thahane Greece Turkey Greece: The Unfinished Story Ira Emke-Poulopolos without Case of Ali S. Gitmez Asian Emigration Countries from Pakistan to the Middle East Shahid Javed Burki South...