A5014749864- Cancer-related gene regulation
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- CAR-T cell therapy research
- Angiogenesis and VEGF in Cancer
- Axon Guidance and Neuronal Signaling
- Cancer Research and Treatments
- Video Analysis and Summarization
- Cytokine Signaling Pathways and Interactions
- Virus-based gene therapy research
- Cancer Treatment and Pharmacology
- CRISPR and Genetic Engineering
- Multimedia Communication and Technology
- Immune Cell Function and Interaction
- Autism Spectrum Disorder Research
- Advanced Steganography and Watermarking Techniques
- Genetics and Neurodevelopmental Disorders
- Cancer, Hypoxia, and Metabolism
Moderna Therapeutics (United States)
2018-2023
Cygnal Therapeutics (United States)
2019-2021
Local mRNA therapy encoding inflammatory cytokines and T cell costimulator OX40L mediates persistent anticancer immunity across tumor models.
While immune checkpoint inhibitors such as anti-PD-L1 are rapidly becoming the standard of care in treatment many cancers, only a subset treated patients have long-term responses. IL12 promotes antitumor immunity mouse models; however, systemic recombinant had significant toxicity and limited efficacy early clinical trials.We therefore designed novel intratumoral mRNA therapy to promote local tumor production while mitigating effects.A single dose (m)IL12 induced IFNγ CD8+ T-cell-dependent...
<h3>Background</h3> Neuropilin-1 (NRP1) is a co-receptor that complexes with diverse ligands and their cognate receptors. As such, it plays role in multiple different biological processes, including axon guidance angiogenesis. NRP1 contains two CUB domains (a1 a2) involved binding the ligand Semaphorin3A (SEMA3A), Factor V/VIII (b1 b2) VEGF one MAM domain (c domain). While functional antibodies anti-tumor activity have been generated against SEMA3A domains, little attention has paid to c of...
Abstract Immunologic responses to cancer involve complex interactions of cells within the tumor microenvironment (TME). These are mediated in part through co-stimulatory and inhibitory transmembrane proteins, cytokines chemokines. Direct intratumoral (ITu) administration messenger RNA results synthesis proteins that can prime enhance an anti-cancer immune response. Priming, expansion migration T-cell clones may also result a systemic or ‘abscopal’ response distal lesions. There is mounting...
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<div>AbstractPurpose:<p>While immune checkpoint inhibitors such as anti–PD-L1 are rapidly becoming the standard of care in treatment many cancers, only a subset treated patients have long-term responses. IL12 promotes antitumor immunity mouse models; however, systemic recombinant had significant toxicity and limited efficacy early clinical trials.</p>Experimental Design:<p>We therefore designed novel intratumoral mRNA therapy to promote local tumor production while...
<div>AbstractPurpose:<p>While immune checkpoint inhibitors such as anti–PD-L1 are rapidly becoming the standard of care in treatment many cancers, only a subset treated patients have long-term responses. IL12 promotes antitumor immunity mouse models; however, systemic recombinant had significant toxicity and limited efficacy early clinical trials.</p>Experimental Design:<p>We therefore designed novel intratumoral mRNA therapy to promote local tumor production while...
Abstract As a central mediator of TH1 immune responses, interleukin 12 (IL-12) in the tumor microenvironment (TME) plays key role driving anti-tumor immunity. Recombinant IL-12 has been reported to promote CD8+ cytotoxic T cell (CTL) dependent immunity wide variety preclinical models. However, systemic recombinant was poorly tolerated early clinical trials. We are therefore investigating whether intra-tumoral (IT) delivery messenger RNA encoding formulated lipid nanoparticles can drive local...
Abstract The pancreas is highly innervated with sensory, autonomic and enteric neurons, recent studies have highlighted the crosstalk between neurons pancreatic cells their potential role in driving tumorigenesis promoting metastasis. Published data has shown that ablation of sensory models ductal adenocarcinoma (PDAC) resulted delayed tumor initiation progression. In addition, perineural invasion (PNI), along nerve, a pathological characteristic frequently observed PDAC. PNI been detected...
Abstract Background Cygnal Therapeutics, pioneer in exoneuronal biology, has identified the neuronal protein, Neuropilin-1 (NRP1) as a critical regulator of tumor growth and anti-tumor immunity. NRP1 is co-receptor that complexes with diverse ligands their cognate receptors. As such, it plays role multiple different biological processes, including axon guidance angiogenesis. contains two CUB domains (a1 a2) involved binding ligand Semaphorin3A (SEMA3A), Factor V/VIII (b1 b2) VEGF one MAM...