A5088247275- Classical Antiquity Studies
- Classical Philosophy and Thought
- Organic Chemistry Synthesis Methods
- Linguistics and language evolution
- Historical, Religious, and Philosophical Studies
- Classical Studies and Legal History
- Byzantine Studies and History
- Fibroblast Growth Factor Research
- Indian and Buddhist Studies
- Eurasian Exchange Networks
- Immune cells in cancer
- Protein Tyrosine Phosphatases
- Chemical synthesis and alkaloids
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Asian Geopolitics and Ethnography
- RNA modifications and cancer
- Cancer-related gene regulation
- Historical and Literary Analyses
- Historical and Linguistic Studies
- Immunotherapy and Immune Responses
- Historical Linguistics and Language Studies
- Historical and Religious Studies of Rome
- Theology and Canon Law Studies
- Historical and Literary Studies
Moderna Therapeutics (United States)
2018-2023
Dana-Farber Cancer Institute
2009-2019
Harvard University
1987-2014
Jesus University
1959-2014
Brigham and Women's Hospital
2008-2012
Ann Arbor Center for Independent Living
2001
Harvard University Press
1977-1987
University of Michigan–Ann Arbor
1969-1970
University of Cambridge
1961
Trinity College
1956
Predicting drug response in cancer patients remains a major challenge the clinic. We have perfected an ex vivo, reproducible, rapid and personalized culture method to investigate antitumoral pharmacological properties that preserves original microenvironment. Response signal transduction inhibitors is determined not only by of target but also mutations other signaling molecules tumor As proof concept, we, therefore, focused on PI3K/Akt pathway, because it plays prominent role its activity...
Local mRNA therapy encoding inflammatory cytokines and T cell costimulator OX40L mediates persistent anticancer immunity across tumor models.
While immune checkpoint inhibitors such as anti-PD-L1 are rapidly becoming the standard of care in treatment many cancers, only a subset treated patients have long-term responses. IL12 promotes antitumor immunity mouse models; however, systemic recombinant had significant toxicity and limited efficacy early clinical trials.We therefore designed novel intratumoral mRNA therapy to promote local tumor production while mitigating effects.A single dose (m)IL12 induced IFNγ CD8+ T-cell-dependent...
Abstract The success of targeted or immune therapies is often hampered by the emergence resistance and/or clinical benefit in only a subset patients. We hypothesized that combining therapy with modulation would show enhanced antitumor responses. Here, we explored combination potential erdafitinib, fibroblast growth factor receptor (FGFR) inhibitor under development, PD-1 blockade an autochthonous FGFR2K660N/p53mut lung cancer mouse model. Erdafitinib monotherapy treatment resulted...
At weaning and again after postweaning gain tests, height width at hips, withers, body length, girth, head length width, muzzle cannon bone circumference measurements were obtained from Angus Hereford bulls heifers born in 1964, 1984, 1985 (n = 989). The cattle the initial final two calf crops selected for when fed either a high-concentrate diet or an all-hay diet. Analysis of variance canonical discriminant analysis used to examine relationships among major sources variation (breed, year...
Abstract Purpose: SPINK1 overexpression has been described in prostate cancer and is linked with poor prognosis many cancers. The objective of this study was to characterize the association between cancer–specific survival. Experimental Design: included 879 participants U.S. Physicians' Health Study Professionals Follow-Up Study, diagnosed (1983–2004) treated by radical prostatectomy. Protein tumor expression evaluated immunohistochemistry on tissue microarrays. Results: Seventy-four (8%)...
Genomic amplification of c-Jun and its upstream kinases have been implicated as a mechanism progression from well-differentiated to dedifferentiated liposarcoma. To further define the role in liposarcoma progression, we performed immunohistochemistry for activating kinase ASK1 on series liposarcomas (n = 81). We correlated results with fluorescence situ hybridization detect amplification. also derived new cell lines protein is expressed majority (91%) their components (59%), but only...
Background Automated scanning devices and image analysis software provide a means to overcome the limitations of manual semiquantitative scoring immunohistochemistry. Common drawbacks automated imaging systems include an inability classify tissue type segregate cytoplasmic nuclear staining. Methods Immunohistochemistry for membranous marker α-catenin, stathmin Ki-67 was performed on microarrays (TMA) archival formalin-fixed paraffin-embedded comprising 471 (α-catenin stathmin) 511 (Ki-67)...
The following collection of possible imitations or reminiscences Propertius in later Latin verse (Ovid excepted) down to Sidonius Apollinaris is intended supplement that published by Hosius his third (Teubner) edition this author and reproduced (along with some additions Professor G. B. A. Fletcher x)) the Prolegomena Enk's recent Cynthia 2). Taken together, these lists should give a fairly well-balanced comprehensive idea Propertius' influence on successors so far as verbal similarities reveal it.
In 49 B.C., on 23rd January by the contemporary calendar, now running over six weeks ahead of schedule, nearly a fortnight after Caesar had crossed Rubicon and week Republican exodus from Rome, Cicero at Minturnae wrote to Atticus, who remained behind, as follows (VII, 13a, 2): L. Caesarem vidi Minturnis a.d. VIII Kal. Febr. mane cum absurdissimis mandatis, non hominem sed scopas solutas, ut id ipsum mihi ille [sc. Caesar] videatur irridendi causa fecisse, qui tantis de rebus huic mandata...
Ancient historians must be thankful for what they get; but it seems a pity that the fall of Corfinium in mid-February, 49 B.C., should best recorded episode Roman warfare, so far as contemporary documents are concerned. Regrets apart, however, affair is interest, psychological and dramatic well austerely military; I think relevant letters Cicero's correspondence will repay further investigation. ‘quae qui legat non multum desideret historiam contextam’—if he reads perceptively. O. E. Schmidt...
Lymphangioleiomyomatosis (LAM) is a rare multisystem disease leading to cystic destruction of the lung parenchyma and associated with abnormal smooth muscle proliferation affecting airways, lymphatics, blood vessels. LAM occurs sporadically or in association tuberous sclerosis complex (TSC). Recent evidence demonstrates role aberrant β-catenin signaling TSC. To further understand pathogenesis examine diagnostic usefulness β-catenin, we examined protein expression 28 pulmonary cases 10 renal...