A5103115384- Atrial Fibrillation Management and Outcomes
- Lipoproteins and Cardiovascular Health
- Acute Myocardial Infarction Research
- Cancer-related molecular mechanisms research
- Heart Failure Treatment and Management
- Hormonal Regulation and Hypertension
- Blood Pressure and Hypertension Studies
- Cardiac Imaging and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Prostate Cancer Treatment and Research
- Angiogenesis and VEGF in Cancer
- Antiplatelet Therapy and Cardiovascular Diseases
- Cancer, Lipids, and Metabolism
- Cancer Genomics and Diagnostics
- Cardiovascular Health and Disease Prevention
- Drug Transport and Resistance Mechanisms
- Lung Cancer Treatments and Mutations
- Acute Ischemic Stroke Management
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Immunotherapy and Biomarkers
- Coronary Interventions and Diagnostics
- Adipose Tissue and Metabolism
- Eicosanoids and Hypertension Pharmacology
- Cancer, Stress, Anesthesia, and Immune Response
Southern Medical University
2011-2025
Nanfang Hospital
2014-2025
Shenzhen Second People's Hospital
2023-2025
Research Center for Eco-Environmental Sciences
2022-2024
Chinese Academy of Sciences
2003-2024
Jiangsu University
2017-2024
Affiliated Hospital of Jiangsu University
2017-2024
Tianjin Medical University
2024
Tianjin Huanhu Hospital
2024
University of Chinese Academy of Sciences
2024
Emerging clinical and experimental evidence demonstrates that neuroinflammation plays an important role in cognitive impairment associated with neuropathic pain. However, how peripheral nerve challenge induces remote inflammation the brain remains largely unknown. Methods: The circulating leukocytes plasma C-X-C motif chemokine 12 (CXCL12) perivascular macrophages (PVMs) were analyzed by flow cytometry, Western blotting, ELISA, immunostaining spared injury (SNI) mice. memory function was...
// Lei Pan 1, 2, * , Wei Liang Jianmei Gu 3, Xueyan Zang 2 Zhenhua Huang 4 Hui Shi Jingyan Chen Min Fu 4, 5 Peng Zhang Xiudi Xiao 1 Qian Wenrong Xu Pengcheng Jiang and Department of Breast Surgery, The Affiliated People's Hospital Jiangsu University, Zhenjiang, 212002, China Key Laboratory Medical Science Medicine, School 212013, 3 Clinical Laboratory, Nantong Tumor Hospital, Nantong, 226361, Institute Digestive Diseases, General These authors contributed equally to this work Correspondence...
Abstract Objectives Long noncoding RNA s (lnc s) play important roles in cancer development and progression. The deregulated expression of LINC 00978 has been reported human cancers. However, the pattern biological gastric ( GC ) remain unclear. In this study, we investigated potential clinical value cancer. Materials methods QRT ‐ PCR was performed to investigate cell lines, tissues serum samples. Cell counting, colony formation, transwell migration matrigel invasion assays were determine...
Tissue factor pathway inhibitor (TFPI) is a multivalent Kunitz-type protease inhibitor, which inhibits Xa directly and in dependent manner the VIIa/tissue catalytic complex. Altered forms of recombinant TFPI (rTFPI) were tested for their ability to inhibit human bovine γ-carboxyglutamate (Gla)-domainless presence absence calciumions, heparin, phospholipids, Va. Sequential deletions positively charged C-terminus produces proteins that have decreasing inhibitory activity against as well...
Prostate cancer is the second leading cause of death among United States men. However, disease aggressiveness varied, with low-grade often being indolent and high-grade accounting for greatest density deaths. Outcomes are also disparate men prostate cancer, upwards 65% having recurrence even after primary treatment. Identification at risk elucidation molecular processes that drive their paramount, as these most likely to benefit from multimodal therapy. We previously showed androgen-induced...
Zhenhua Huang 1,2,3 , Paula J Hurley 1 Brian W Simons Luigi Marchionni 2,3 David M Berman Ashley E Ross and Edward Schaeffer Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD, USA. 2 Pathology, 3 Oncology, Received: June 26, 2012; Accepted: 30, Published: July 2, Keywords: Sox9, prostate, development, cancer, initiation Correspondence: Schaeffer, email: // Abstract Prostate cancer is one the most common malignancies second leading cause death from in men. The molecular...
Long non-coding RNAs (lncRNAs) have emerged as important regulators of human cancers. However, the functional roles lncRNAs and mechanisms responsible for their aberrant expression in gastric cancer (GC) not been well characterized. In this study, we examined lncRNA UFC1 GC by qRT-PCR explored its correlation with clinicopathological parameters. vitro cell assays vivo animal studies were performed to determine progression. was elevated predicted poorer prognosis GC. knockdown inhibited while...
Abstract Background Depression is a common, easily ignored, accompanied disease of gastric cancer (GC) patients and often observed with elevated plasma catecholamine levels. frequently promotes GC progression leads to poor clinical outcomes; however, the molecular mechanisms underlying depression‐induced remain poorly understood. We aimed study effects depression on explore possible mediating action depression‐associated catecholamines GC. Methods states were graded using Patient Health...
Abstract Cyanobacterial blooms, which not only threaten the health and stability of aquatic ecosystems but also influence microbial community within, emerges as one most concerning problems in China. However, how cyanobacterial blooms affect spatiotemporal variation communities remains relatively unclear. In this study, we used high-throughput sequencing to investigate bacterial spatiotemporally vary along with main bloom phases upstream rivers a eutrophicated water source reservoir. Both...
Objective This study aims to investigate the relationship between atherogenic index of plasma (AIP) and diabetes risk in Chinese non-obese adults. is important because incidence significant populations, evidence regarding this association limited. Methods We conducted a retrospective cohort with 82,977 used Cox proportional hazards regression assess baseline AIP levels incidence. also employed cubic spline functions smooth curve fitting potential nonlinear relationships. Sensitivity subgroup...
Objectives The pulse pressure (PP) is an important factor influencing the outcomes of diabetes. However, relationship between PP and prediabetes has been rarely studied how this association might be impacted by hypertension not clear. Methods In study, we retrospectively included 184,252 adults from 32 regions in China, spanning 2010 to 2016. Cox regression sensitivity analysis were used examine prediabetes. For hypertensive population, proportional hazards smooth curve fitting performed...
ABSTRACT This study endeavors to assess the potential protective role of bergapten (BP) in mitigating abdominal aortic aneurysm (AAA) and decipher underlying mechanisms molecular targets. Network pharmacology was utilized search for targets BP against AAA. Molecular docking dynamics simulations were validate interaction with core targets, then therapeutic effect mechanism on AAA verified by using an elastase‐induced model. analysis identified five pharmacological BP, including EGFR, SRC,...
The water-soluble protein from Phascolosoma esculenta was hydrolyzed by pepsin to obtain the hydrolysate with angiotensin I-converting enzyme (ACE) inhibitory activity. (PEPH) then further separated membrane bioreactor system, ion-exchange chromatography, gel filtration, and reversed phase high-performance liquid chromatography (RP-HPLC) a novel ACE peptide named as PeP IC50 value of 135 M isolated. amino acid sequence, Ala-Trp-Leu-His-Pro-Gly-Ala-Pro-Lys-Val-Phe, identified matrix-assisted...
Post-translational modification of protein is one the most important biological processions in field proteomics and bioinformatics. Pupylation a novel post translational which small, intrinsically disordered prokaryotic ubiquitin-like conjugated to lysine residues potential segments. Both experimental computational prediction methods such modified sites have proved be challenging issue. Computational mainly aimed at extracting effective features from In this paper, statistical feature...
Abstract Homologous recombination (HR) repair is an important determinant of chemosensitivity. However, the mechanisms underlying HR regulation remain largely unknown. Cysteine-rich intestinal protein 1 (CRIP1) a member LIM/double-zinc finger family and overexpressed associated with prognosis in several tumor types. to date, functional role CRIP1 cancer biology poorly understood. Here we found that downregulation causes deficiency concomitant increase cell sensitivity cisplatin, epirubicin,...
Circulating tumor DNA (ctDNA) has been becoming a novel convenient and noninvasive method for dynamically monitoring landscape of genomic information to guild personalized cancer treatment. In this study we comprehensively evaluated the additional value plasma ctDNA routine tissue next generation sequencing (NGS) therapeutically targetable mutations in lung cancers.The tissues peripheral blood samples from 423 cases patients with were subjected NGS oncodrivers (EGFR, ERBB2, ALK, ROS1, C-MET,...