A5049687528- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Advanced biosensing and bioanalysis techniques
- Circular RNAs in diseases
- Pain Mechanisms and Treatments
- Organ Transplantation Techniques and Outcomes
- Cancer Research and Treatments
- Plant Virus Research Studies
- CRISPR and Genetic Engineering
- Ubiquitin and proteasome pathways
- Caveolin-1 and cellular processes
- Cancer Mechanisms and Therapy
- RNA Interference and Gene Delivery
- Neuroinflammation and Neurodegeneration Mechanisms
- Pancreatic function and diabetes
- Immune cells in cancer
- Cancer, Lipids, and Metabolism
- Lipid metabolism and disorders
- Endoplasmic Reticulum Stress and Disease
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
Beijing Tian Tan Hospital
2025
Capital Medical University
2025
Hangzhou First People's Hospital
2023-2025
Harbin Medical University
2020-2025
First Affiliated Hospital of Harbin Medical University
2020-2025
Westlake University
2025
Second Affiliated Hospital of Nanjing Medical University
2021-2024
Sun Yat-sen University
2017-2024
Zhejiang University
2023-2024
Northwestern University
2024
Emerging clinical and experimental evidence demonstrates that neuroinflammation plays an important role in cognitive impairment associated with neuropathic pain. However, how peripheral nerve challenge induces remote inflammation the brain remains largely unknown. Methods: The circulating leukocytes plasma C-X-C motif chemokine 12 (CXCL12) perivascular macrophages (PVMs) were analyzed by flow cytometry, Western blotting, ELISA, immunostaining spared injury (SNI) mice. memory function was...
Abstract Background The endoplasmic reticulum (ER) regulates critical processes, including lipid synthesis, which are affected by transmembrane proteins localized in the ER membrane. One such protein, protein 147 (TMEM147), has recently been implicated for its role hepatocellular carcinoma (HCC) tumorigenesis; however, mechanisms remain unclear. We investigated of TMEM147 HCC and underlying mechanisms. Methods expression was examined human cells adjacent non-tumorous tissues using...
Abstract Most existing bioluminescence imaging methods can only visualize the location of engineered bacteria in vivo, generally precluding natural bacteria. Herein, we leverage bacteria-specific ATP-binding cassette sugar transporters to internalize luciferase and luciferin by hitchhiking them on unique carbon source Typically, synthesized bioluminescent probes are made glucose polymer (GP), luciferase, Cy5 ICG-modified silicon nanoparticles their substrates GP D-luciferin-modified...
Sepsis-associated liver injury is with poor survival in intensive care units. Metformin well known for its therapeutic effects; however, impact on treating due to sepsis remains poorly understood. This study investigated the effects of metformin aged mice suffering from sepsis-associated injury. Male C57BL/6 J (18–19 months) were divided into 3 groups: 1) intraperitoneal injection sterile normal saline (C group), 12.5 mg/kg lipopolysaccharide (LPS) induce (LPS and 25 (MET) at 1 h after LPS...
Herein, we designed and synthesized a novel microRNA (miR)-responsive nanoantenna capable of early diagnosis smart treatment acute kidney injury (AKI). The was made two miniature gold nanorods (AuNRs) (e.g., length: ∼48 nm; width: ∼9 nm) linked together by rectangular DNA origami nanostructure (rDONs) scaffold ∼90 ∼60 (rDONs@AuNR dimer). surface plasmon resonance peak the constructed is located within NIR-II window ∼1060 nm), thus guaranteeing photoacoustic (PA) imaging in deep tissues....
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a new tick-borne pathogen that can cause severe hemorrhagic fever. Fever caused by SFTSV infectious disease has posed great threat to public health. Therefore, fast, sensitive, low-cost, and field-deployable detection method for diagnosing essential surveillance control. In this study, we developed rapid, highly instrument-flexible utilizes recombinase polymerase amplification the CRISPR/Cas12a system. We found three copies of L...
Sensitive and reliable clustered regularly interspaced short palindromic repeats (CRISPR) quantification without preamplification of the sample remains a challenge. Herein, we report CRISPR Cas12a-powered silicon surface-enhanced Raman spectroscopy (SERS) ratiometric chip for sensitive quantification. As proof-of-concept application, select platelet-derived growth factor-BB (PDGF-BB) as target. We first develop microfluidic synthetic strategy to prepare homogeneous SERS substrates, in which...
Optogenetic therapy has emerged as a promising technique for the treatment of ocular diseases; however, most optogenetic tools rely on external blue light to activate photoswitch, whose relatively strong phototoxicity may induce retinal damage. Herein, we present demonstration camouflage nanoparticle-based vectors in situ bioluminescence-driven retinoblastoma. In biomimetic vectors, photoreceptor CRY2 and its interacting partner CIB1 plasmid are camouflaged with folic acid ligands luciferase...
Intrahepatic cholangiocarcinoma (ICC) is a highly malignant and aggressive cancer whose incidence mortality continue to increase, whereas its prognosis remains dismal. Tumor-associated macrophages (TAMs) promote progression immune microenvironment remodeling through direct contact secreted mediators. Targeting TAMs has emerged as promising strategy for ICC treatment. Here, we revealed the potential regulatory function of responsive gene 1 (IRG1) in macrophage polarization. We found that IRG1...
Metal–organic frameworks (MOFs) are promising as novel disinfectants due to the reactive oxygen species (ROS) produced in their photocatalytic processes. The optimal MOF is screened best disinfectant, representing high-efficacy production of ROS under conditions. However, current methods screen abundant MOFs for disinfectant application generally semiquantitative or ex situ [such electron paramagnetic resonance (EPR) measurements], so achieving a strategy that can quantitatively an and...
Nicotinamide N-methyltransferase (NNMT), a member of the family, plays an important role in tumorigenesis. However, its expression and biological functions intrahepatic cholangiocarcinoma (iCCA) remain to be established. In our study, we identified NNMT as oncogene iCCA provided mechanistic insights into roles progression. High tissues was using western blotting immunohistochemistry (IHC). We significantly higher level human than that adjacent normal tissues. Increased promoted cell...
Escherichia coli K1 (EC-K1) can bypass the blood–brain barrier (BBB) and cause meningitis. Excitingly, we find "dead EC-K1" safely penetrate BBB because they retain intact structure chemotaxis of live EC-K1, while losing their pathogenicity. Based on this, develop a safe EC-K1"-based drug delivery system, in which EC-K1 engulf maltodextrin (MD)-modified therapeutics through bacteria-specific MD transporter pathway, followed by inactivation via UV irradiation. We demonstrate that dead...
Abstract Hepatocellular carcinoma (HCC) is one of the most common fatal cancers worldwide, and identification novel treatment targets prognostic biomarkers urgently needed because its unsatisfactory prognosis. Regulator G-protein signaling 19 (RGS19) a multifunctional protein that regulates progression various cancers. However, specific function RGS19 in HCC remains unclear. The expression was determined clinical samples. Functional molecular biology experiments involving were performed to...
Abstract Intestinal epithelium serves as the first barrier against infections and injuries that mediate colonic inflammation. Colorectal cancer is often accompanied with chronic Differed from its well-known oncogenic role in many malignancies, we present here Golgi membrane protein 1 (GOLM1, also referred to GP73) suppresses colorectal tumorigenesis via maintenance of intestinal epithelial barrier. GOLM1 deficiency mice conferred susceptibility mucosal inflammation colitis-induced damage,...
Arsenic trioxide (ATO) is indicated as a broad-spectrum medicine for variety of diseases, including cancer and cardiac disease. While the role ATO in hepatic ischemia/reperfusion injury (HIRI) has not been reported. Thus, purpose this study was to identify effects on HIRI. In present study, we established 70% warm I/R partial hepatectomy (30% resection) animal models vivo hepatocytes anoxia/reoxygenation (A/R) vitro with pretreatment further assessed liver function by histopathologic...
Abstract Recent studies have shown that abnormal activity of acid sphingomyelinase (Asm) has been associated with a range psychiatric disorders including schizophrenia and depression. However, the role Asm in regulation anxiety remains unclear. In present study, we employed Asm-knockout (Asm KO) mice to investigate association between using behavioral tests, RNA sequencing, q-PCR, immunohistochemical staining, other methods. The results showed KO exhibit enhanced anxiety-like behaviors, such...
Background Pediatric renal abscesses is a severe infectious disease with long treatment period. Due to atypical symptoms, there risk of delayed diagnosis, missed and misdiagnosis. Inadequate or incomplete can lead prolonged hospital stays, even Irreversible kidney damage. This study aimed analyze the clinical characteristics pediatric abscesses, aiming for early diagnosis timely, appropriate treatment. Methods A retrospective analysis was conducted on manifestations, laboratory tests,...