Abstract Bacteria can bypass the blood-brain barrier (BBB), suggesting possibility of employment bacteria for combating central nervous system diseases. Herein, we develop a bacteria-based drug delivery glioblastoma (GBM) photothermal immunotherapy. The system, which name as ‘Trojan bacteria’, consists loaded with glucose polymer and photosensitive ICG silicon-nanoparticles. In an orthotopic GBM mouse model, demonstrate that intravenously injected BBB, targeting penetrating tissues. Upon 808...

Abstract Electrotherapy is of great interest in the field tissue repair as an effective, well‐tolerated, and noninvasive treatment. Triboelectric nanogenerator (TENG) has shown advantages promoting wound healing due to its peak output characteristic low Joule heating effect. However, it limited infected poor antimicrobial capacity. Here, a wearable triboelectric stimulator (WTS) developed that consists flexible TENG (F‐TENG) triboelectric‐responsive drug delivery hydrogel (TR‐DDH) for...

Herein, we present the first example of a silicon nanoshuttle-based security ink simultaneously featuring attractive optical and magnetic properties, suitable for fluorescent anti-counterfeiting encryption.

Abstract Simultaneous imaging and treatment of infections remains a major challenge, with most current approaches being effective against only one specific group bacteria or not useful for diagnosis. Here we develop multifunctional nanoagents that can potentially be used caused by diverse bacterial pathogens. The are made fluorescent silicon nanoparticles (SiNPs) functionalized glucose polymer (e.g., poly[4-O-(α-D-glucopyranosyl)-D-glucopyranose]) loaded chlorin e6 (Ce6). They rapidly...

Fluorescent silicon nanoparticles (SiNPs), as the most important zero-dimensional nanostructures, hold high promise for long-awaited silicon-based optic applications. There currently remain major challenges green, inexpensive, and mass production of fluorescent SiNPs, resulting in difficulties sufficiently exploiting properties these remarkable materials. Here, we show that small-sized (∼3.8 nm) SiNPs can be produced through biomimetic synthesis rapid (10 min), low-cost, environmentally...

Silicon nanoparticle (SiNP) nanocarriers feature strong fluorescence, ultrasmall size, robust photostability, and tunable drug-loading capacity. Using SiNP nanocarriers, the first example of long-term cancer cell tracking is successfully demonstrated. Furthermore, in vivo experiments show that tumor-bearing mice treated with survive over 20 d without observable tumor growth, demonstrating high-efficacy chemotherapy Si nanocarriers. As a service to our authors readers, this journal provides...

We herein report a kind of one-dimensional biocompatible fluorescent silicon nanorods (SiNRs) with tunable lengths ranging ∼100–250 nm, which can be facilely prepared through one-pot microwave synthesis. In addition to the strong fluorescence (quantum yield value: ∼15%) and negligible toxicity, resultant SiNRs exhibit excitation wavelength-dependent photoluminescence whose maximum emission wavelength ranges from ∼450 ∼600 nm under serial wavelengths 390 560 providing feasibility for...

Ni-rich cathode materials have attracted wide attention on account of their high specific capacity. However, the poor cycle retention materials, especially at voltage or temperature, is recognized as main obstacle for extensive commercialization. In this research, we propose a new strategy doping NCM622 (LiNi0.6Co0.2Mn0.2O2) with Ta5+ to improve structural stability due Ta–O dissociation bond energy. XRD refinement results indicate that almost all are located in Li sites play pillar role and...

Currently optical-based techniques for in vivo microbial population imaging are limited by low depth and highly light-scattering tissue; moreover, generally effective against only one specific group of bacteria. Here, we introduce an therapy strategy, which different bacteria actively eat the glucose polymer (GP)-modified gold nanoparticles through ATP-binding cassette (ABC) transporter pathway, followed laser irradiation-mediated aggregation bacterial cells. As a result, aggregates display...

Current treatments for fundus disorders, such as intravitreal injections, pose risks, including infection and retinal detachment, are limited in their ability to deliver macromolecular drugs across the blood‒retinal barrier. Although non-invasive methods safer, delivery efficiency remains suboptimal (<5%). We have developed a wearable electrodriven switch (WES) that improves of macromolecules fundus. The WES system, which integrates an drug lens with square wave generator, leverages...

Fluorescent sensors suitable for dynamic measurement of intracellular pH (pHi) fluctuations should feature the following properties: feeble cytotoxicity, wide-pH range response, and strong fluorescence coupled with good photostability, which are still remaining scanty to date. Herein, by functionalizing fluorescent silicon nanoparticles (SiNPs) pH-sensitive dopamine (DA) pH-insensitive rhodamine B isothiocyanate (RBITC), we present first demonstration SiNPs-based sensors, simultaneously...

Crystalline, excitation-wavelength-dependent fluorescent and small-sized silicon nanoparticles (SiNPs) are prepared by using gramineae plants as natural accessible reaction precursors.

More and more attention has been focused on Ni-rich ternary materials due to their superior specific capacity, but they still suffer inherent structural irreversibility rapid capacity degradation under a high voltage. Oxidation of unstable oxygen will lead the irreversible transformation structure. Taking into account strong W–O bond, an appropriate amount W-doping is studied reinforce thermal stability electrochemical performance LiNi0.6Co0.2Mn0.2O2 (NCM622) at 4.5 V. Combining experiments...

Single-crystal LiNi1–x–yCoxMnyO2 cathode materials can effectively suppress intergranular cracks that usually is seen in commercial polycrystal materials. However, the surface structure degradation for single-crystal still aggravated at a higher cutoff voltage (over 4.5 V). In this work, we prepare LiNi0.6Co0.2Mn0.2O2 via solid-state method and then coat an ultrathin Li–Si–O layer on their by wet coating method. The results show with deliver excellent cycling performance even of V. optimized...

Herein, we designed and synthesized a novel microRNA (miR)-responsive nanoantenna capable of early diagnosis smart treatment acute kidney injury (AKI). The was made two miniature gold nanorods (AuNRs) (e.g., length: ∼48 nm; width: ∼9 nm) linked together by rectangular DNA origami nanostructure (rDONs) scaffold ∼90 ∼60 (rDONs@AuNR dimer). surface plasmon resonance peak the constructed is located within NIR-II window ∼1060 nm), thus guaranteeing photoacoustic (PA) imaging in deep tissues....

Optogenetic therapy has emerged as a promising technique for the treatment of ocular diseases; however, most optogenetic tools rely on external blue light to activate photoswitch, whose relatively strong phototoxicity may induce retinal damage. Herein, we present demonstration camouflage nanoparticle-based vectors in situ bioluminescence-driven retinoblastoma. In biomimetic vectors, photoreceptor CRY2 and its interacting partner CIB1 plasmid are camouflaged with folic acid ligands luciferase...

To date, long-term and continuous ultrasonic imaging for guiding the puncture biopsy remains a challenge. In order to address this issue, multimodality therapeutic method was developed in present study facilitate fluorescence imaging-guided precision diagnosis combined therapy of tumors. regard, certain types photoactivated gas-generating nanocontrast agents (PGNAs), capable exhibiting both ability along with photothermal sonodynamic function, were designed fabricated. The advantages these...

Extensive investigations have been carried out for evaluating the toxicology of various nanomaterials (e.g., carbon- and metal-based nanomaterials), which offer invaluable information assessing feasibility nanomaterial-based wide-ranging applications. In recent years, sufficient efforts made to develop fluorescent small-sized silicon nanoparticles (SiNPs) as a novel optical material simultaneously featuring strong fluorescence ultrahigh photostability, providing high promise myriad...

Long-term and real-time investigation of the dynamic process pHi changes is critically significant for understanding related pathogenesis diseases design intracellular drug delivery systems. Herein, we present a one-step synthetic strategy to construct ratiometric pH sensors, which are made europium (Eu)-doped one-dimensional silicon nanorods (Eu@SiNRs). The as-prepared Eu@SiNRs have distinct emission maxima peaks at 470 620 nm under 405 excitation. Of particular note, fluorescence intensity...

Abstract The development of effective and safe vehicles to deliver small interfering RNA (siRNA) chemotherapeutics remains a major challenge in interference-based combination therapy with chemotherapeutics, which has emerged as powerful platform treat drug-resistant cancer cells. Herein, we describe the novel all-in-one fluorescent silicon nanoparticles (SiNPs)-based nanomedicine for imaging-guided co-delivery siRNA doxorubicin (DOX). This approach enhanced therapeutic efficacy...