A5079416953- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Mosquito-borne diseases and control
- Genomics, phytochemicals, and oxidative stress
- Vector-Borne Animal Diseases
- Viral Infections and Immunology Research
- Advanced biosensing and bioanalysis techniques
- Ion Channels and Receptors
- interferon and immune responses
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Fire effects on ecosystems
- Plant Virus Research Studies
- Virus-based gene therapy research
- Transgenic Plants and Applications
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Bacteriophages and microbial interactions
- Helicobacter pylori-related gastroenterology studies
- Click Chemistry and Applications
- CRISPR and Genetic Engineering
- Viral Infectious Diseases and Gene Expression in Insects
- Animal Disease Management and Epidemiology
- Herpesvirus Infections and Treatments
- Animal Virus Infections Studies
Tianjin University
2019-2025
Tianjin Infectious Diseases Hospital
2025
Chengdu University
2024
Institute of Microbiology
2022
Center for Disease Control
2014
National Institute for Viral Disease Control and Prevention
2003-2013
Chinese Center For Disease Control and Prevention
2010
Jiangsu Agri-animal Husbandry Vocational College
2010
Lanzhou Institute of Husbandry and Pharmaceutical Sciences
2009
China Agricultural University
2005
The discovery of an emerging viral disease, severe fever with thrombocytopenia syndrome (SFTS), caused by SFTS virus (SFTSV), has prompted the need to understand pathogenesis SFTSV. We are unique in establishing infectious model C57/BL6 mice, resulting hallmark symptoms and leukocytopenia. Viral RNA histopathological changes were identified spleen, liver, kidney. However, replication was only found which suggested spleen be principle target organ Moreover, number macrophages platelets...
Severe fever with thrombocytopenia syndrome is an emerging infectious disease caused by a novel bunyavirus (SFTSV). Lack of vaccines and inadequate therapeutic treatments have made the spread virus global concern. Viral nucleocapsid protein (N) essential for its transcription replication. Here, we present crystal structures N from SFTSV homologs Buenaventura (BUE) Granada (GRA) viruses. The reveal that phleboviral folds into compact core domain extended N-terminal arm mediates...
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a new tick-borne pathogen that can cause severe hemorrhagic fever. Fever caused by SFTSV infectious disease has posed great threat to public health. Therefore, fast, sensitive, low-cost, and field-deployable detection method for diagnosing essential surveillance control. In this study, we developed rapid, highly instrument-flexible utilizes recombinase polymerase amplification the CRISPR/Cas12a system. We found three copies of L...
ABSTRACT Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne bunyavirus high pathogenicity. There has been a gradual increase in the number of reported cases recent years, morbidity and mortality rates. The cyclic GMP-AMP synthase (cGAS)-stimulator interferon genes (STING) signaling pathway plays important role innate immune defense activated by viral infection; however, cGAS-STING during SFTSV infection still unclear. In this study, we investigated...
To evaluate the role of small mammals as hosts severe fever with thrombocytopenia syndrome virus (SFTSV), we tested serum samples from rodents and shrews in China, collected 2013. SFTSV antibodies RNA were detected, suggesting that might be for SFTSV.
Excessive drinking poses serious health risks and is closely associated with oxidative damage. The KEAP1-NRF2-ARE axis serves as the primary antioxidant system. However, existing small molecule inhibitors are all covalently bound to KEAP1, meaning that once bound, they not easily dissociated, while continuous inhibition of KEAP1 exhibits severe side effects. In this study, BLI, CETSA, Pull-down, Co-IP HDX-MS assay analysis were conducted detect binding behavior natural product, capsaicin...
Background/Objectives: Enterovirus 71 (EV71) and coxsackieviruses A16 (CA16), A10 (CA10), A6 (CA6) are the primary pathogens that cause hand, foot, mouth disease (HFMD). Currently, many manufacturers developing bivalent, trivalent, tetravalent vaccines target these antigens. Cell-based neutralization assay (CBNA), gold standard for detecting neutralizing antibodies (NtAbs), which used as indicators of HFMD vaccine efficacy, has several limitations. We aimed to develop a novel NtAbs against...
Severe fever with thrombocytopenia syndrome (SFTS) is a novel emerging acute infectious disease caused by severe virus (SFTSV), characterized high and thrombocytopenia. It has been proved that traditional Chinese medicine (TCM) displayed definite therapeutic effects on viral hemorrhagic fever, indicating its potential to treat SFTS. In this study, SFTS-relative key targets were predicted via Gene ontology (GO) analysis Kyoto Encyclopedia of Genes Genomes (KEGG) enrichment analysis. Molecular...
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne pathogen that causes severe hemorrhagic fever. Although SFTSV poses serious threat to public health and was recently isolated, its pathogenesis remains unclear. In particular, the relationship between infection host cell cycle has not been described. Here, we show for first time both asynchronized synchronized SFTSV-susceptible cells arrest at G 2 /M checkpoint following accumulation of this facilitates viral...
Influenza A virus (IAV) poses a significant threat to human health, which calls for the development of efficient detection methods. The present study constructed fluorescence resonance energy transfer (FRET) system based on novel fluorescent probes and graphene oxide (GO) detecting H5N1 IAV hemagglutinin (HA). Here, we synthesized small (sub-20 nm) sandwich-structured upconversion nanoparticles (UCNPs) (SWUCNPs short) with high efficiency, allows controlling emitter in thin shell. π–π...
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a newly identified phlebovirus associated severe hemorrhagic in humans. Studies have shown that SFTSV nucleoprotein (N) induces BECN1-dependent autophagy to promote viral assembly and release. However, the function of other proteins regulating has not been reported. In this study, we identify NSs, nonstructural protein forms viroplasm-like structures cytoplasm infected cells as component mediating SFTSV-induced autophagy. We found...
Excessive drinking poses serious health risks and is closely associated with oxidative damage. The KEAP1-NRF2-ARE axis serves as the primary antioxidant system. However, existing small molecule inhibitors are all covalently bound to KEAP1, meaning that once bound, they not easily dissociated, while continuous inhibition of KEAP1 exhibits severe side effects. In this study, BLI, CETSA, Pull-down, Co-IP HDX-MS assay analysis were conducted detect binding behavior natural product, capsaicin...
Enterovirus D68 (EV-D68) is an emerging pathogen causing severe respiratory infections, and the immune evasion mediated by EV-D68 structural protein has been under discussion for several years. Our early research identified that VP3 targets specifically interferon regulatory factor 7 to inhibit type I signaling, but not 3, which indispensable mitochondrial antiviral signaling (MAVS)-activated signaling. Interestingly, in this study, we found co-localizes interacts with MAVS. Furthermore,...
Enterovirus D68 (EV-D68) is an emerging pathogen associated with severe respiratory diseases and neurological complications, such as acute flaccid myelitis. EV-D68 has developed sophisticated mechanisms to hijack host translation machinery, facilitating its replication impairing mRNA translation. In this study, we demonstrate that cleaves La-related protein 1 (LARP1) poly(A)-binding cytoplasmic (PABPC1) through proteases 3C pro 2A . Our results indicate overexpressing LARP1 PABPC1...
Stress granules (SGs) are formed in the cytoplasm under environmental stress, including viral infection. Human enterovirus D68 (EV-D68) is a highly pathogenic virus which can cause serious respiratory and neurological diseases. At present, there no effective drug or vaccine against EV-D68 infection, relationship between infection SGs poorly understood. This study revealed biological function of Our results suggest that induced accumulation SG marker proteins Ras GTPase-activated...
Enterovirus D68 (EV-D68) is a globally emerging pathogen causing severe respiratory illnesses mainly in children. The protease from EV-D68 could impair type I interferon (IFN-I) production. However, the role of structural protein antagonizing host antiviral responses remains largely unknown. We showed that VP3 interacted with IFN regulatory factor 7 (IRF7), and this interaction suppressed phosphorylation nuclear translocation IRF7 then repressed transcription IFN. Furthermore, inhibited TNF...
Type I interferon (IFN-I) plays a critical role in host cancer immunosurveillance, but its expression is often impaired the tumor microenvironment. We aimed at testing hypothesis that cationic lipid nanoparticle delivery of β (IFNβ)-encoding plasmid to tumors effective restoring IFNβ suppress immune evasion. determined IFN-I function suppression depends on cells. activates Cxcl9 and Cxcl10 enhance T cell infiltration. RNA-Seq detected low level IFNα13 colon tissue. scRNA-Seq revealed...
Enterovirus D68 (EV-D68) can cause respiratory diseases and acute flaccid paralysis, posing a great threat to public health. Interferons are cytokines secreted by host cells that have broad-spectrum antiviral effects, inducing the expression of hundreds interferon-stimulated genes (ISGs). EV-D68 activates ISG early in infection, but at later stage, virus suppresses expression, strategy evolved antagonize interferons. Here, we explore protein, suppressor cytokine signaling 3 (SOCS3), is...