A5100391510- Diet and metabolism studies
- Nanoparticle-Based Drug Delivery
- Orthopedic Infections and Treatments
- Histiocytic Disorders and Treatments
- Oral microbiology and periodontitis research
- Bone Metabolism and Diseases
- Systemic Lupus Erythematosus Research
- Nanoplatforms for cancer theranostics
- Metabolism and Genetic Disorders
- Rheumatoid Arthritis Research and Therapies
- Orthopaedic implants and arthroplasty
- Pain Mechanisms and Treatments
- Bone and Joint Diseases
- Bone health and treatments
- Immune cells in cancer
- Osteoarthritis Treatment and Mechanisms
- Asthma and respiratory diseases
- Metabolism, Diabetes, and Cancer
- Thyroid Cancer Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Thyroid Disorders and Treatments
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Bone health and osteoporosis research
University of Nebraska Medical Center
2016-2025
Nebraska Medical Center
2015-2025
Chengdu University of Traditional Chinese Medicine
2025
Zhongda Hospital Southeast University
2017-2025
Capital Medical University
2021-2024
Shandong Center for Disease Control and Prevention
2024
Beijing Children’s Hospital
2020-2024
Center for Children
2024
Endocrinology Research Center
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Abstract Background Abnormal lipid metabolism poses a risk for prediabetes. However, research on parameters used to predict the of prediabetes is scarce, and significance traditional untraditional remains unexplored in This study aimed comprehensively evaluate association between 12 their diagnostic value. Methods cross-sectional included data from 100,309 Chinese adults with normal baseline blood glucose levels. New onset was outcome concern. Untraditional were derived parameters....
Glut-1 deficiency syndrome (Glut-1 DS, OMIM #606777) is characterized by infantile seizures, developmental delay, acquired microcephaly and hypoglycorrhachia. It caused haploinsufficiency of the blood–brain barrier hexose carrier. Heterozygous mutations or hemizygosity GLUT-1 gene cause DS. We generated a heterozygous haploinsufficient mouse model targeted disruption promoter exon 1 regions gene. GLUT-1+/− mice have epileptiform discharges on electroencephalography (EEG), impaired motor...
BACKGROUND: Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory disease that affects approximately 0.5 to 1 percent of the adults worldwide and commonly results in joint destruction significant impairment quality life. RA considered as an autoimmune with unknown etiology. Many pathogenic pathways have been revealed recently, which led development various novel therapies. OBJECTIVE: The current treatments include 4 categories: non-steroidal anti-inflammatory drugs (NSAIDs),...
Rheumatoid arthritis (RA) is a chronic autoimmune disease of unknown etiology. Effective treatment this disorder has been hampered by the lack availability agents that selectively target affected joint tissue. We developed novel pH-sensitive drug delivery system dexamethasone (Dex) based on an N-(2-hydroxypropyl)methacrylamide copolymer (P-Dex) and have shown specifically accumulates in inflamed joints animal model arthritis. hypothesize arthrotropism local acidosis-mediated release provide...
As an emerging research direction, nanomedicine has been increasingly utilized to treat inflammatory diseases. In this head-to-head comparison study, four established formulations of dexamethasone, including liposomes (L-Dex), core-cross-linked micelles (M-Dex), slow releasing polymeric prodrugs (P-Dex-slow), and fast (P-Dex-fast), were evaluated in adjuvant-induced arthritis rat model with equivalent dose treatment design. It was found that after a single i.v. injection, the slower drug...
Cellular interactions between delta and mu opioid receptors (DORs MORs), including heteromerization, are thought to regulate analgesia. However, the identity of nociceptive neurons in which such could occur vivo remains elusive. Here we show that DOR-MOR co-expression is limited small populations excitatory interneurons projection spinal cord dorsal horn unexpectedly predominates ventral motor circuits. Similarly, rare parabrachial, amygdalar, cortical brain regions processing information....
Polymerizable and hydrolytically cleavable dexamethasone (DEX, red dot in picture) derivatives were covalently entrapped core-cross-linked polymeric micelles that prepared from a thermosensitive block copolymer (yellow gray building block). By varying the oxidation degree of thioether drug linker, release rate DEX could be controlled. The DEX-loaded used for efficient treatment inflammatory arthritis two animal models.
Emerging clinical and experimental evidence demonstrates that neuroinflammation plays an important role in cognitive impairment associated with neuropathic pain. However, how peripheral nerve challenge induces remote inflammation the brain remains largely unknown. Methods: The circulating leukocytes plasma C-X-C motif chemokine 12 (CXCL12) perivascular macrophages (PVMs) were analyzed by flow cytometry, Western blotting, ELISA, immunostaining spared injury (SNI) mice. memory function was...
Abstract Periodontitis is a widespread oral disease characterized by continuous inflammation of the periodontal tissue and an irreversible alveolar bone loss, which eventually leads to tooth loss. Four-octyl itaconate (4-OI) cell-permeable derivative has been recognized as promising therapeutic target for treatment inflammatory diseases. Here, we explored, first time, protective effect 4-OI on inhibiting destruction, ameliorating local inflammation, underlying mechanism in periodontitis....
The negative impact of COVID-19 on physical activity has been improved, while the research changes in fitness that may be caused by inactivity is still scarce. This study aims to explore pandemic lockdown fitness, and initial indicators their during adolescents. A longitudinal including 265 adolescents aged 14.1 ± 0.4 years old was conducted China. Physical measurement at baseline follow-up were respectively measured before (November 2019) after (July 2020). Several aerobic (i.e., 800-m or...
Abstract Mitochondrial dysfunction plays a major role in the development of intervertebral disc degeneration (IDD). Sirtuin 5 (SIRT5) participates maintenance mitochondrial homeostasis through its desuccinylase activity. However, it is still unclear whether succinylation or SIRT5 involved impairment mitochondria and IDD induced by excessive mechanical stress. Our 4D label-free quantitative proteomic results showed decreased expression rat nucleus pulposus (NP) tissues under loading....
Risk assessment for triple-vessel disease (TVD) remain challenging. Stress hyperglycemia represents the regulation of glucose metabolism in response to stress, and stress ratio (SHR) is recently found reflect true acute hyperglycemic status. This study aimed evaluate prognostic value SHR its role risk stratification TVD patients with coronary syndrome (ACS).
Abstract Glut‐1 deficiency syndrome was first described in 1991 as a sporadic clinical condition, later shown to be the result of haploinsufficiency. We now report family with affecting 5 members over 3 generations. The behaves an autosomal dominant condition. Affected manifested mild severe seizures, developmental delay, ataxia, hypoglycorrhachia, and decreased erythrocyte 3‐ O ‐methyl‐ D ‐glucose uptake. Seizure frequency severity were aggravated by fasting, responded carbohydrate load....
HPMA copolymer−d-aspartic acid octapeptide (D-Asp8) conjugates have been found to target the entire skeleton after systemic administration. In a recent study using ovariectomized rat model of osteoporosis, we surprisingly discovered that D-Asp8 would favorably recognize resorption sites in skeletal tissues, while another bone-targeting moiety, alendronate (ALN), directs delivery system both formation and sites. Atomic force microscopy (AFM) analyses reveal ALN has stronger binding...
The biodistribution and pharmacokinetics of bone-targeting N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer−alendronate conjugates were evaluated following intravenous administration radioiodinated to young healthy BALB/c mice. synthesis a polymerizable cathepsin K cleavable alendronate derivative, N-methacryloylglycylglycylprolylnorleucylalendronate, enabled the preparation HPMA with varying composition. Using RAFT (reversible addition−fragmentation chain transfer) polymerization...