A5046984887- Neuropeptides and Animal Physiology
- Pain Mechanisms and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Antimicrobial Peptides and Activities
- Memory and Neural Mechanisms
- Biochemical and Structural Characterization
- Immune Response and Inflammation
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Dermatology and Skin Diseases
- Receptor Mechanisms and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological disorders and treatments
- Prion Diseases and Protein Misfolding
- RNA Interference and Gene Delivery
- Acupuncture Treatment Research Studies
- Pharmacological Effects of Natural Compounds
- Urticaria and Related Conditions
- HIV Research and Treatment
- Musculoskeletal pain and rehabilitation
- Pharmacological Receptor Mechanisms and Effects
- Cancer, Stress, Anesthesia, and Immune Response
- Asthma and respiratory diseases
- Visual perception and processing mechanisms
- Neuroendocrine regulation and behavior
Neurosciences Institute
2017-2024
Stanford University
2017-2024
Johns Hopkins University
2021-2022
Johns Hopkins Medicine
2021-2022
Harvard University
2014-2015
Northeastern University
2011-2014
McLean Hospital
2014
Rider University
1993
In humans, intradermal administration of β-alanine (ALA) and bovine adrenal medulla peptide 8-22 (BAM8-22) evokes the sensation itch. Currently, it is unknown which human dorsal root ganglion (DRG) neurons express receptors these pruritogens, MRGPRD MRGPRX1, respectively, cutaneous afferents pruritogens activate in primate. situ hybridization studies revealed that MRGPRX1 are co-expressed a subpopulation TRPV1+ DRG neurons. electrophysiological recordings nonhuman primates (Macaca...
Microglia take on an altered morphology during chronic opioid treatment. This morphological change is broadly used to identify the activated microglial state associated with side effects, including tolerance and opioid-induced hyperalgesia (OIH). display similar responses in spinal cord after peripheral nerve injury (PNI). Consistent this observation, functional studies have suggested that microglia by opioids or PNI engage common molecular mechanisms induce hypersensitivity. In article, we...
Inhibition of Gβγ-subunit signaling to phospholipase C β3 has been shown potentiate morphine-mediated antinociception while attenuating the development tolerance and dependence in mice. The objective this study was determine effect inhibition on other pharmacological effects, such as respiratory depression, constipation, hyperlocomotion, mediated by μ-opioid receptor. inhibitor, gallein, administered C57BL/6J mice intraperitoneal injection before morphine, data were compared with treated...
Maladaptive behavioral responses characteristic of post-traumatic stress disorders are notably resistant to treatment. We hypothesized that the pharmacological disruption memories activated during reconsolidation might reverse established stress-induced increases in depression-like behaviors and cocaine reward. C57BL/6J mice were subjected repeated social defeat (SDS), examined for time spent immobile a subsequent forced swim test (FST). An additional set SDS-exposed place-conditioned with...
Alcoholism is associated with specific brain abnormalities revealed through postmortem studies, including a reduction in glial cell number and dysregulated glutamatergic neurotransmission. Whether these contribute to the etiology of alcoholism, are consequences alcohol use, or both still unknown.We investigated role astrocytic glutamate uptake ethanol (EtOH) binge drinking mice, using "drinking dark" (DID) paradigm by blocking transporter (GLT-1) intracerebroventricular (ICV) administration...
Healthy skin maintains a diverse microbiome and potent immune system to fight off infections. Here, we discovered that epithelial cell-derived antimicrobial peptides defensins activate orphan GPCRs Mrgpra2a/b on neutrophils. This signaling axis is required for effective neutrophil-mediated immunity homeostasis. We generated mutant mouse lines lacking the entire Defensin (Def) gene cluster or Mrgpra2a/b. Def Mrgpra2 animals both exhibited dysbiosis, with reduced microbial diversity expansion...
Abstract Microglia take on an altered morphology during chronic opioid treatment. This morphological change is broadly used to identify the activated microglial state associated with side effects, including tolerance and opioid-induced hyperalgesia (OIH). Following treatment peripheral nerve injury (PNI) microglia in spinal cord display similar responses. Consistent this observation, functional studies have suggested that by PNI or opioids engage common molecular mechanisms induce...