A5064374742- Pain Mechanisms and Treatments
- Ion channel regulation and function
- Neurobiology and Insect Physiology Research
- Ion Channels and Receptors
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- Light effects on plants
- Cardiac electrophysiology and arrhythmias
- Advanced Sensor and Energy Harvesting Materials
- Tactile and Sensory Interactions
- Photoreceptor and optogenetics research
- Autism Spectrum Disorder Research
- Respiratory and Cough-Related Research
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Transgenic Plants and Applications
- Nicotinic Acetylcholine Receptors Study
- Sirtuins and Resveratrol in Medicine
- Circadian rhythm and melatonin
- Musculoskeletal pain and rehabilitation
- Anesthesia and Pain Management
- Neuroscience and Neural Engineering
- Transcranial Magnetic Stimulation Studies
- Infant Health and Development
- Nerve injury and regeneration
Université de Montpellier
2011-2024
Institut de Génomique Fonctionnelle
2011-2024
Centre National de la Recherche Scientifique
2011-2024
Inserm
2011-2024
Stanford University
2014-2018
Palo Alto University
2018
Neurosciences Institute
2014-2018
Bicêtre Hospital
1997
Research Article24 March 2011Open Access Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors Juliette Descoeur Département de Physiologie, CNRS, UMR-5203, Institut Génomique Fonctionnelle, Montpellier, France INSERM, U661, Universités Montpellier 1 and 2, Clermont Université, Université d'Auvergne, Pharmacologie Fondamentale et Clinique la Douleur, Clermont-Ferrand, U 766, Search for more papers by this author Vanessa Pereira Anne...
de niveau recherche, publiés ou non, émanant des établissements d'enseignement et recherche français étrangers, laboratoires publics privés.
Cellular interactions between delta and mu opioid receptors (DORs MORs), including heteromerization, are thought to regulate analgesia. However, the identity of nociceptive neurons in which such could occur vivo remains elusive. Here we show that DOR-MOR co-expression is limited small populations excitatory interneurons projection spinal cord dorsal horn unexpectedly predominates ventral motor circuits. Similarly, rare parabrachial, amygdalar, cortical brain regions processing information....
C-low-threshold mechanoreceptors (C-LTMRs) are unique among C-unmyelinated primary sensory neurons. These neurons convey two opposite aspects of touch sensation: a sensation pleasantness, and injury-induced mechanical pain. Here, we show that TAFA4 is specific marker C-LTMRs. Genetic labeling in combination with electrophysiological recordings TAFA4+ have intrinsic properties mechano-nociceptors. TAFA4-null mice exhibit enhanced chemical hypersensitivity following inflammation nerve injury...
Summary This study deciphers the mechanism of inhibition T-type calcium channels by TTA-A2, demonstrating that TTA-A2 affinity for CaV3.2-inactivated state confers a preferential analgesic efficacy toward pathological pain. encoded CaV3.2 isoform are expressed in nociceptive primary afferent neurons where they contribute to hyperalgesia and thus considered as potential therapeutic target treat Here we report small organic state-dependent channel antagonist efficiently inhibits recombinant...
Affective touch is necessary for proper neurodevelopment and sociability. However, it remains unclear how the neurons innervating skin detect affective social behaviors. The C low-threshold mechanoreceptors (C-LTMRs), a specific population of somatosensory in mice, appear particularly well suited, physiologically anatomically, to perceive touch. their contribution sociability has not been resolved yet. Our observations revealed that C-LTMR functional deficiency induced isolation reduced...
Spinal dorsal horn circuits receive, process, and transmit somatosensory information. To understand how specific components of these contribute to behavior, it is critical be able directly modulate their activity in unanesthetized vivo conditions. Here, we develop experimental tools that enable optogenetic control spinal circuitry freely moving mice using commonly available materials. We use examine mechanosensory processing the cord observe activation somatostatin-positive interneurons...
from teaching and research institutions in France or abroad, public private centers.L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques niveau recherche, publiés ou non, émanant des établissements d'enseignement recherche français étrangers, laboratoires publics privés.
Nerve growth factor/tropomyosin receptor kinase A (NGF/TrkA) signaling plays a key role in neuronal development, function, survival, and growth. The pathway is implicated neurodegenerative disorders including Alzheimer's disease, chronic pain, inflammation, cancer. NGF binds the extracellular domain of TrkA, leading to activation receptor's intracellular domain. As TrkA highly dynamic, mechanistic studies would benefit from tool with high spatial temporal resolution. Here we present design...
Confronting oxytocin and vasopressin deficits in autism spectrum disorders rare syndromes brought promises disappointments for the treatment of social disabilities. We searched downstream targets alleviating a mouse model Prader-Willi syndrome Schaaf-Yang syndrome, both associated with high prevalence autism. found population neurons lateral septum-activated on termination contacts-which inhibit as per degree peer affiliation. These are somatostatin expressing receptors coupled to GABA-B...
Background and Purpose T‐type calcium channels, mainly the Ca v 3.2 subtype, are important contributors to nociceptive signalling pathway. We investigated their involvement in inflammation related pain‐like symptoms. Experimental Approach The of channels was using genetic pharmacological inhibition assess mechanical allodynia/hyperalgesia oedema development two murine inflammatory pain models. location involved symptoms studied mice with knocked out C‐low threshold mechanoreceptors (C‐LTMR)...
Abstract Affective touch is necessary for proper neurodevelopment and sociability. However, it still unclear how the neurons innervating skin detect affective social behaviours. To clarify this matter, we targeted a specific population of somatosensory in mice, named C-low threshold mechanoreceptors (C-LTMRs), that appears particularly well suited physiologically anatomically to perceive but whose contribution these processes has not yet been resolved. Our observations revealed C-LTMRs...
Abstract T-type/Cav3 calcium channels are key in neuronal excitability and pain processing with Cav3.2 being the prominent isoform primary sensory neurons of dorsal root ganglion (DRG). Its pharmacological inhibition or gene silencing induces analgesia several preclinical models inflammatory neuropathic pain. However, presence Cav3.2, encoded by CACNA1H gene, human DRG remains unresolved. Using RNA in-situ hybridization electrophysiological recordings, we show that DRGs express a subset...
Abstract Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder marked by social deficits, repetitive behaviors, and atypical sensory perception. The link between ASD skin abnormalities, inducing itchiness, has never been investigated in depth. This study explores mechanical itch sensitivity the Shank3 ΔC/ΔC mouse model. Key observations include heightened scratching response to deformation hypersensitivity (i.e. alloknesis) mice. In mice, ex vivo electrophysiological experiments...
ABSTRACT The disinhibition of the excitatory PKCγ interneurons plays a central role during mechanical allodynia in dorsal horn spinal cord, routing harmless information to nociceptive pathways. T-type calcium channel Cav3.2, necessary for and cold allodynia, is found most neurons cord. In this study, Cav3.2 was studied after its pharmacological inhibition conditional deletion (KO) GFP-Flox KI x PKCγ-CreERT2 Ai14 mice normal conditions spared-nerve-injury (SNI) model neuropathic pain....
Abstract Nerve growth factor/tropomyosin receptor kinase A (NGF/TrkA) signaling plays a key role in neuronal development, function, survival, and growth. The pathway is implicated neurodegenerative disorders including Alzheimer’s disease, chronic pain, inflammation, cancer. NGF binds the extracellular domain of TrkA, leading to activation receptor’s intracellular domain. TrkA highly dynamic, thus mechanistic studies would benefit from tool with high spatial temporal resolution. Here we...