A5068453167- Legionella and Acanthamoeba research
- Vibrio bacteria research studies
- Bacterial Genetics and Biotechnology
- Bacterial biofilms and quorum sensing
- Cancer Research and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nerve injury and regeneration
- Stress Responses and Cortisol
- Amoebic Infections and Treatments
- Neonatal and Maternal Infections
- Diet and metabolism studies
- Autism Spectrum Disorder Research
- Gut microbiota and health
- Transgenic Plants and Applications
- Neurofibromatosis and Schwannoma Cases
- Neuroblastoma Research and Treatments
- Endoplasmic Reticulum Stress and Disease
- Streptococcal Infections and Treatments
- Virus-based gene therapy research
- Escherichia coli research studies
- Nanoplatforms for cancer theranostics
- Pneumonia and Respiratory Infections
Centre National de la Recherche Scientifique
2015-2024
Inserm
2024
Université de Montpellier
2024
Institut de Génomique Fonctionnelle
2024
Massachusetts General Hospital
2022-2023
Harvard University
2022-2023
Sorbonne Paris Cité
2019
Sorbonne Université
2019
Institut Pasteur
2015-2018
Centre de Gestion Scientifique
2015-2018
The carbon storage regulator protein CsrA regulates cellular processes post-transcriptionally by binding to target-RNAs altering translation efficiency and/or their stability. Here we identified and analyzed the direct targets of in human pathogen Legionella pneumophila. Genome wide transcriptome, proteome RNA co-immunoprecipitation followed deep sequencing a wild type csrA mutant strain 479 RNAs with potential interaction sites located untranslated coding regions mRNAs or known non-coding...
Schwannomas are slow-growing benign neoplasms that develop throughout the body causing pain, sensory/motor dysfunction, and death. Because bacterial immunotherapy has been used in treatment of some malignant neoplasms, we evaluated attenuated Salmonella typhimurium strains as immunotherapies for murine schwannomas. Several were tested, including VNP20009, a highly strain was previously shown to be safe human subjects with advanced VNP20009 mutant altered motility other properties included...
Abstract FIC proteins regulate molecular processes from bacteria to humans by catalyzing post-translational modifications (PTM), the most frequent being addition of AMP or AMPylation. In many AMPylating proteins, a structurally conserved glutamate represses AMPylation and, in mammalian FICD, also supports deAMPylation BiP/GRP78, key chaperone unfolded protein response. Currently, direct signal regulating these has not been identified. Here, we use X-ray crystallography and vitro PTM assays...
ABSTRACT Legionella pneumophila is an environmental bacterium that parasitizes protozoa, but it may also infect humans, thereby causing a severe pneumonia called Legionnaires’ disease. To cycle between the environment and eukaryotic host, L. regulating expression of virulence factors in life cycle-dependent manner: replicating bacteria do not express factors, whereas transmissive are highly motile infective. Here we show Hfq important regulator this network. expressed at very low levels...
Streptococcus agalactiae (or Group B Streptococcus, GBS) is a commensal bacterium present in the intestinal and urinary tracts of approximately 30% humans. We others previously showed that PI-2a pilus polymers, made backbone pilin PilB, tip adhesin PilA cell wall anchor protein PilC, promote adhesion to host epithelia biofilm formation. Affinity-purified pili from GBS strain NEM316 were recognized by N-acetylneuraminic acid (NeuNAc, also known as sialic acid) specific lectins such Elderberry...
Abstract Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder marked by social deficits, repetitive behaviors, and atypical sensory perception. The link between ASD skin abnormalities, inducing itchiness, has never been investigated in depth. This study explores mechanical itch sensitivity the Shank3 ΔC/ΔC mouse model. Key observations include heightened scratching response to deformation hypersensitivity (i.e. alloknesis) mice. In mice, ex vivo electrophysiological experiments...
Schwannomas are slow-growing benign peripheral nerve sheath tumors derived from Schwann-lineage cells that develop in association with NF2-related schwannomatosis (NF2) and (NF3), as well spontaneously. Individuals affected NF2 NF3 have multiple schwannomas arising throughout life. Surgical resection, the standard management, is limited scope efficacy itself associated significant morbidity. We previously shown direct intratumoral injection of attenuated Salmonella Typhimurium (S....
Abstract FIC proteins regulate molecular processes from bacteria to humans by catalyzing post-translational modifications (PTM), the most frequent being addition of AMP using ATP as a cofactor, reaction coined AMPylation. In large group AMPylating proteins, which includes single-domain bacterial and animal FICD/HYPE, AMPylation is intrinsically repressed structurally conserved glutamate. Curiously, FICD departs previously characterized in that it acts bifunctionally AMPylate deAMPylate its...