A5103060814- Pain Mechanisms and Treatments
- Cultural and Mythological Studies
- Ion Channels and Receptors
- Cannabis and Cannabinoid Research
- Ion channel regulation and function
- Philosophical and Cultural Analysis
- Spanish Philosophy and Literature
- Dermatology and Skin Diseases
- Child and Adolescent Health
- Archaeological and Historical Studies
- Platelet Disorders and Treatments
- Multiple Sclerosis Research Studies
- Historical Linguistics and Language Studies
- History, Culture, and Society
- Neuropeptides and Animal Physiology
- Neuroscience and Music Perception
- Autoimmune Bullous Skin Diseases
- Spanish Literature and Culture Studies
- Infant Development and Preterm Care
- Diabetes and associated disorders
- Neurobiology and Insect Physiology Research
- Asthma and respiratory diseases
- Historical Studies in Latin America
- Pediatric Pain Management Techniques
- Long-Term Effects of COVID-19
National Autonomous University of Honduras
2025
Universidad El Bosque
2019
Fundación Universitaria Juan N. Corpas
2019
Hospital Universitario San Ignacio
2019
University of California, San Francisco
2010-2015
University of California, Irvine
2010
Universidad Nacional Autónoma de México
1966
Identifying points of control in inflammation is essential to discovering safe and effective antiinflammatory medicines. Palmitoylethanolamide (PEA) a naturally occurring lipid amide that, when administered as drug, inhibits inflammatory responses by engaging peroxisome proliferator-activated receptor-alpha (PPAR-alpha). PEA preferentially hydrolyzed the cysteine amidase N-acylethanolamine-hydrolyzing acid (NAAA), which highly expressed macrophages. Here we report discovery potent selective...
Dorsal root ganglia (DRG) neurons, including the nociceptors that detect painful thermal, mechanical, and chemical stimuli, transmit information to spinal cord neurons via glutamatergic peptidergic neurotransmitters. However, specific contribution of glutamate pain generated by distinct sensory modalities or injuries is not known. Here we mice in which vesicular transporter 2 (VGLUT2) ablated selectively from DRG neurons. We report conditional knockout (cKO) Slc17a6 gene encoding VGLUT2...
There is continuing controversy relating to the primary afferent neurotransmitter that conveys itch signals spinal cord. Here, we investigated DRG and cord expression of putative afferent-derived “itch” neurotransmitter, gastrin-releasing peptide (GRP). Using ISH, qPCR, immunohistochemistry, conclude GRP expressed abundantly in cord, but not neurons. Titration most commonly used antiserum tissues from wild-type mutant mice indicates only selective for at high dilutions. Paralleling these...
Background An alarming portion of patients develop persistent or chronic pain following surgical procedures, but the mechanisms underlying transition from acute to states are not fully understood. In general, endocannabinoids (ECBs) inhibit nociceptive processing by stimulating cannabinoid receptors type 1 (CB1) and 2 (CB2). We have previously shown that intrathecal administration a CB2 receptor agonist reverses both incision-induced behavioral hypersensitivity associated over-expression...
El síndrome de Devic, también conocido como trastorno del espectro la neuromielitis óptica (NMOSD, por sus sigla en inglés), es considerado una enfermedad inflamatoria, desmielinizante y autoinmune sistema nervioso central que afecta su mayoría los nervios ópticos, el quiasma óptico médula espinal. Si bien algunos casos se puede simular un cuadro clínico similar a esclerosis múltiple, hoy día conocen aspectos imagenológicos, inmunológicos patológicos permiten establecer las diferencias entre...