A5100436869- Pain Mechanisms and Treatments
- Magnetism in coordination complexes
- Cancer Treatment and Pharmacology
- Organic and Molecular Conductors Research
- Pain Management and Opioid Use
- Nerve injury and regeneration
- Cholinesterase and Neurodegenerative Diseases
- Antibiotics Pharmacokinetics and Efficacy
- Nicotinic Acetylcholine Receptors Study
- Anesthesia and Sedative Agents
- Neurobiology and Insect Physiology Research
- Heart Rate Variability and Autonomic Control
- Ion channel regulation and function
- Exercise and Physiological Responses
- Neuropeptides and Animal Physiology
- Biochemical effects in animals
- Neuroscience and Neuropharmacology Research
- Spine and Intervertebral Disc Pathology
- Veterinary Pharmacology and Anesthesia
- Botulinum Toxin and Related Neurological Disorders
- Stress Responses and Cortisol
- Metal-Catalyzed Oxygenation Mechanisms
- Advanced Drug Delivery Systems
- Lanthanide and Transition Metal Complexes
- Ion Channels and Receptors
University of Utah
1995-2022
Hunan Provincial Maternal and Child Health Hospital
2016-2022
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2020
Huazhong University of Science and Technology
2019
Tongji Hospital
2019
University of Alabama at Birmingham
2018
Guangdong Province Women and Children Hospital
2017
Sun Yat-sen University
2015
University of California, San Francisco
2010-2013
Peking University
2010
Two ambient-temperature molecule-based magnets (Curie temperatures Tc of ∼350 K and 372 K) are presented, which the result research to identify factors in synthesis that control magnetic properties compounds. The goal is increase Tc. two hexacyanochromate described (see also cover this issue) reasons for differences between them earlier (Tc ∼ 315 discussed. High Curie temperature materials may find applications shielding memory storage devices, example.
The adequate stimuli and molecular receptors for muscle metaboreceptors nociceptors are still under investigation. We used calcium imaging of cultured primary sensory dorsal root ganglion (DRG) neurons from C57Bl/6 mice to determine candidates metabolites that could be the detect these stimuli. Retrograde DiI labeling determined some innervated skeletal muscle. found combinations protons, ATP, lactate were much more effective than individually applied compounds activating rapid increases in...
Abstract The periaqueductal gray (PAG) is a significant modulator of both analgesic and fear behaviors in humans rodents, but the underlying circuitry responsible for these two phenotypes incompletely understood. Importantly, it not known if there way to produce analgesia without anxiety by targeting PAG, as modulation glutamate or GABA neurons this area initiates antinociceptive anxiogenic behavior. While dopamine (DA) ventrolateral PAG (vlPAG)/dorsal raphe display supraspinal effect, their...
Dorsal root ganglia (DRG) neurons, including the nociceptors that detect painful thermal, mechanical, and chemical stimuli, transmit information to spinal cord neurons via glutamatergic peptidergic neurotransmitters. However, specific contribution of glutamate pain generated by distinct sensory modalities or injuries is not known. Here we mice in which vesicular transporter 2 (VGLUT2) ablated selectively from DRG neurons. We report conditional knockout (cKO) Slc17a6 gene encoding VGLUT2...
Remarkable thermal stability is exhibited by [FeII(tcne)2]⋅x CH2Cl2 (57Fe Mössbauer spectra reveal that the oxidation state of iron II), which was prepared treating MeCN solvate FeI2 with tetracyanoethylene (TCNE). This method, can also be applied to synthesize analogous Mn, Co, and Ni compounds, provides a simple route novel molecule-based magnets interesting properties.
Background One of the most common side effects paclitaxel was dosage-dependently painful neuropathy. Various reports indicated that spinal neuroinflammation involved in paclitaxel-induced neuropathic pain. This study investigated effect icariin on and peripheral neuropathy rats. Methods Two parts were included this study. In part one, pain investigated. Mechanical thresholds measured as primary outcomes. Production proinflammatory factors (tumor necrosis factor-α, interleukin-1 β,...
Objectives. To examine the effects of locally applied heat on systemic delivery fentanyl through Transdermal Fentanyl Delivery System.
Bone cancer pain (BCP) is the most common complication in patients with bone cancer. Glial cell line-derived neurotrophic factor (GDNF) believed to be involved chronic conditions. In this article, expression and roles of GDNF were studied a rat model BCP induced by tibia injection Walker 256 mammary gland carcinoma cells. Significant mechanical thermal hyperalgesia ongoing observed beginning as early day 5 post injection. The level protein examined on 16 after was decreased L3 dorsal root...
We report magnetic studies of $\mathrm{Fe}(\mathrm{TCNE}{)}_{2}\ensuremath{\cdot}x({\mathrm{CH}}_{2}{\mathrm{Cl}}_{2}),$ a member the family high-${T}_{c}$ molecule-based magnets, $M(\mathrm{TCNE}{)}_{x}\ensuremath{\cdot}y(\mathrm{solvent})$ $(M=\mathrm{V},$ Mn, TCNE=tetracyanoethelyne). Based on extensive static and dynamic measurements we show that this system has complex behavior, with mixture ferrimagnetic random anisotropy characteristics. The constricted hysteresis curve spin-flop...
Painful peripheral neuropathy is a severe side effect in oxaliplatin therapy that compromises cancer patients' quality of life. However, its underlying pathogenic mechanisms remain largely unknown. Here, we found intraperitoneal consecutive administration significantly increased excitability small diameter dorsal root ganglion neurons and induced thermal hyperalgesia rats. Furthermore, the CX3CL1 expression was after treatment, intrathecal injection neutralizing antibody against markedly...
Patients with chronic neuropathic pain (CNP) have a higher incidence to develop depression. However, its pathogenesis has not yet been fully elucidated. Here we aimed investigate the role of inflammatory cytokines in CNP-related anhedonia, which is core symptom depression, and explore effects ketamine parecoxib on anhedonia.A rat model spared nerve injury (SNI) was constructed mimic CNP. Hierarchical cluster analysis sucrose preference test (SPT) applied classify SNI rats into anhedonia...
Results of static and dynamic magnetic studies the compound ${\mathrm{Mn}(\mathrm{TCNE})}_{x}\ensuremath{\cdot}y({\mathrm{CH}}_{2}{\mathrm{Cl}}_{2})$ (TCNE =tetracyanoethylene) are reported. Curie-Weiss analysis high-temperature susceptibility data indicates a relatively strong exchange. The ac susceptibility, measured as function frequency temperature, reveals frequency-independent peaks in both in-phase out-of-phase components near 75 K. Additional components, which dependent, observed 10...
BACKGROUND: Neuropathic pain is an intractable and complex disease. Recent studies have shown a close relationship between endoplasmic reticulum (ER) stress neuropathic pain. Here, we investigated the effect of α-asarone, ER inhibitor, on chronic constriction injury (CCI)–induced METHODS: Two parts were included in this study. In part 1, rats assigned to 7 groups: sham group, + α-asarone 20 mg/kg CCI vehicle 5 10 group. After surgery, treated with or normal saline daily. Pain thresholds...
Although most severe peripheral nerve injuries result from high-speed mechanisms, there is no laboratory model to replicate this clinical condition.To qualitatively and quantitatively describe microanatomical injury of rapid stretch.The sciatic nerves 36 Sprague-Dawley rats were subjected rapid-stretch injury, using fixed-direction strain produced via constrained weight drop applied an intact nerve. Nerve severity was categorized by biomechanical parameters. Injury microarchitecture...
High-resolution 1H nuclear magnetic resonance (NMR) analysis was employed to molecularly screen the lipid, lipid oxidation product (LOP), and antioxidant compositions of four natural (unrefined) cod liver oil (CLO) products. Products 1–3 were non-fermented CLOs, whilst Product 4 isolated from pre-fermented livers. Supporting analytical data that acquired included biogenic amine, flavanone, tannin, phenolic antioxidant, α-tocopherol, oxygen radical absorbance capacity (ORAC) determinations by...
In China, two common methods are used to detect serum glucose, glucose oxidase (GOD) and hexokinase (HK) methods. We evaluated five commercially available reagent kits with the Center of Disease Control (CDC) HK reference method.Five routine were compared method according Clinical Laboratory Standards Institute (CLSI) guideline (EP9-A2). These performed on an "open channel" Olympus 5400 analyzer.All closely correlated (r > 0.9998). Compared method, Olympus-HK Roche-GOD showed a very small...
Pain is often debilitating, and current treatments are neither universally efficacious nor without risks. Transient receptor potential (TRP) ion channels offer alternative targets for pain relief, but little known about the regulation or identities of endogenous TRP ligands that affect inflammation pain. Here, transcriptomic targeted lipidomic analysis damaged tissue from mouse spinal nerve ligation (SNL)-induced chronic model revealed a time-dependent increase in Cyp1b1 mRNA concurrent...