A5079549742- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Glioma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Advanced NMR Techniques and Applications
- Caveolin-1 and cellular processes
- NMR spectroscopy and applications
- Inflammatory Biomarkers in Disease Prognosis
- Molecular spectroscopy and chirality
- Metabolomics and Mass Spectrometry Studies
- Advanced MRI Techniques and Applications
- Cardiac tumors and thrombi
- Soft tissue tumor case studies
- Vascular Tumors and Angiosarcomas
- Chromatin Remodeling and Cancer
- Neurofibromatosis and Schwannoma Cases
- Meningioma and schwannoma management
- Bone Tumor Diagnosis and Treatments
- Synthetic Organic Chemistry Methods
- Crystallography and molecular interactions
- Fluorine in Organic Chemistry
- Tumors and Oncological Cases
- Cancer Cells and Metastasis
- Hedgehog Signaling Pathway Studies
- Neuroblastoma Research and Treatments
WinnMed
2020-2025
Mayo Clinic in Florida
2020-2025
Jacksonville College
2020-2025
Mayo Clinic
2024-2025
Mayo Clinic in Arizona
2014-2025
De Montfort University
2016-2024
Loughborough University
2011-2022
Emory University Hospital
2015-2020
Emory University
2012-2019
Stepping Hill Hospital
2018
PURPOSE Since activity of sorafenib was observed in sarcoma patients a phase I study, we performed multicenter II study daily oral with recurrent or metastatic sarcoma. PATIENTS AND METHODS We employed multiarm design, each representing subtype its own Simon optimal two-stage design. In arm, 12 who received 0 to 1 prior lines therapy were treated (0 3 for angiosarcoma and malignant peripheral-nerve sheath tumor). If at least one Response Evaluation Criteria Solid Tumors (RECIST) observed, 25...
Neuropsychiatric systemic lupus erythematosus, which often entails cognitive disturbances and memory loss, has become a major complication for patients. Previously, we developed murine model of neuropsychiatric based on Abs that cross-react with dsDNA the NMDA receptor (NMDAR). We showed these impair cognition when they access CNS through breach in blood–brain barrier (BBB) triggered by lipopolysaccharide. Because studies show patients possess anti-NMDAR their serum cerebrospinal fluid,...
Purpose To determine the prognostic significance of histologic type in radiation-associated soft tissue sarcomas (RASs) and whether RASs are associated with an inferior prognosis compared sporadic (STSs). Patients Methods One hundred thirty primary were identified from 7,649 STS patients 1982 to 2007. Multivariate analysis clinicopathologic factors for disease-specific survival (DSS) was performed RASs, a multivariate radiation exposure also sarcomas. A matched-cohort malignant fibrous...
Abstract The adult mammalian forebrain harbors neuronal precursor cells in the subependymal zone (SZ). Neuronal progenitors also persist human SZ and have been cultured from epileptic temporal lobe. In present study, we sought to identify these neural situ, direct their expansion differentiation vitro. We prepared explants of SZ, obtained lobe resections refractory epileptics. resultant cultures were treated with fibroblast growth factor‐2 (FGF–2) for a week, concurrent exposure [ 3 H]...
The zinc 1,4-benzenedicarboxylates [Zn3(bdc)3(H2O)3] . 4 DMF (1; bdc = 1,4-benzenedicarboxylate), [Zn(bdc)(H2O)] (2), and [Zn(bdc)] (3) crystallise at room temperature from mixtures of toluene/ dimethylformamide (DMF) under concentrated, dilute dry conditions, respectively. structure phase 1 (monoclinic: P2(1)/c, a 13.065(1), b 9.661(1), c 18.456(1) A, beta 106.868(2) degrees) consists layers containing stacks three cations linked by mono- bidentate groups. Structure converts to the known 2...
Malignant fibrous histiocytoma (MFH), now termed high-grade undifferentiated pleomorphic sarcoma, is a commonly diagnosed mesenchymal tumor, yet both the underlying molecular mechanisms of tumorigenesis and cell origin remain unidentified. We present evidence demonstrating that human stem cells (hMSCs) are progenitors MFH. DKK1, Wnt inhibitor mediator hMSC proliferation, overexpressed in Using recombinant proteins, antibody depletion, siRNA knockdown strategies specific elements, we show...
Abstract Gli signaling is critical for central nervous system development and implicated in tumorigenesis. To monitor gliomas vivo, we created platelet-derived growth factor–induced a Gli-luciferase reporter mouse. We find that activation found correlates with grade. In addition, sonic hedgehog (SHH) expressed these tumors also identify microvascular proliferation pseudopalisades, elements define high-grade as SHH-producing microenvironments. describe two populations of stromal cells reside...
Abstract Purpose: Biomarkers can facilitate diagnosis, monitor treatment response, and assess prognosis in some patients with cancer. YKL-40 matrix metalloproteinase-9 (MMP-9) are two proteins highly differentially expressed by malignant gliomas. We obtained prospective longitudinal serum samples from gliomas to determine whether or MMP-9 could be used as markers. Experimental Design: Serum were concurrently magnetic resonance imaging scans. determined ELISA the values correlated patient's...
BackgroundThe cellular basis of long term radiation damage in the brain is not fully understood.Methods and FindingsWe administered a dose 25Gy to adult rat brains while shielding olfactory bulbs. Quantitative analyses were serially performed on different regions over 15 months. Our data reveal an immediate permanent suppression SVZ proliferation neurogenesis. The bulb demonstrates transient but remarkable SVZ-independent ability for compensation maintenance calretinin interneuron...
We report 10 cases of a non-neurocytic, purely neuronal tumor affecting adults. Situated in the cerebral hemispheres, with 7 confined to temporal lobes, most presented seizures as their principal clinical manifestations. On magnetic resosnance imaging (MRI), tumors generally appeared solid and non-contrast enhancing minimal diffuse infiltration, edema, or mass effect. Six examples demonstrated internal nodularity. Microscopically, cells were largely distributed into discrete coalescent...
Erythroblast transformation specific related gene (ERG), a proto-oncogene member of the erythroblast transcription factor family, is sensitive marker endothelial differentiation and expressed in vascular tumours, including angiosarcomas (AS). Immunohistochemistry necessary for diagnosis AS fine needle aspirates where low cellularity lack preserved tissue architecture impedes diagnosis. The aim this study was to assess utility an ERG-enriched immunohistochemistry panel cytological AS.25...
Molecular analysis has reshaped the landscape of high grade sinonasal tumors by defining novel entities and identifying recurrent mutations in established tumor types. However, teratocarcinosarcoma (TCS), a rare aggressive with intermixed teratomatous, carcinomatous, sarcomatous elements, remains poorly understood. The multiphenotypic differentiation TCS engendered persistent controversy about its histogenesis leads to diagnostic overlap several other malignancies. In this study, we...
Objective: To describe the clinicopathologic and radiologic features of solitary fibrous tumors head neck.
Abstract Paediatric rhabdomyosarcomas (RMS) are classified into two major subtypes based on histological appearance, embryonal (ERMS) and alveolar (ARMS), but this clinically critical distinction is often difficult morphological grounds alone. ARMS, the more aggressive subtype, associated in most cases with unique recurrent translocations fusing PAX3 or PAX7 transcription factor genes to FKHR . In contrast, ERMS lacks genetic alterations. To identify novel diagnostic markers potential...
Prostate-specific membrane antigen (PSMA) is expressed in endothelium of vessels malignant solid tumors but not normal vessels.To examine whether neovasculature glioblastoma multiforme (GBM) expresses PSMA. Design.-After institutional review board approval at Memorial Sloan-Kettering Cancer Center, formalin-fixed paraffin-embedded tissue from 32 patients who underwent a maximally safe neurologic resection during 2004 to 2005 for GBM (World Health Organization criteria) was obtained. We...
To discriminate lipomas from atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) we perform fluorescence in situ hybridization (FISH) for MDM2 amplification several problematic situations: "lipomas" >10 cm, lesions with equivocal atypia, recurrent "lipomas," all retroperitoneal/pelvic/abdominal "lipomas", and cases not fitting the above criteria but having worrisome clinical or radiologic features. ascertain validity of these criteria, have reviewed our experience 301...
Novel sensing technologies for liquid biopsies offer promising prospects the early detection of metabolic conditions through omics techniques. Indeed, high-field nuclear magnetic resonance (NMR) facilities are routinely used metabolomics investigations on a range biofluids in order to rapidly recognise unusual patterns patients suffering from diseases. However, these techniques restricted by prohibitively large size and cost such facilities, suggesting possible role smaller, low-field NMR...
Although most cases of atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) can be diagnosed solely on the basis histologic features, those lacking diagnostic features require ancillary studies for accurate classification. Fluorescent in situ hybridization (FISH) amplification MDM2 has been considered gold standard diagnosis these situations. Immunostaining and/or CDK4 adopted as a surrogate method because its high concordance rate with FISH and lower cost. However, examining...
Soft tissue sarcomas (STS) have minimal expression of PD-L1, a biomarker for PD-1 therapy efficacy. Radiotherapy (RT) has been shown to increase PD-L1 pre-clinically. We examined the pre- and post-RT, in 46 Stage II-III STS patients treated with pre-operative RT (50–50.4 Gy 25–28 fractions) followed by resection. Five additional who did not receive were utilized as controls. on biopsy resection samples was evaluated immunochemistry using anti monoclonal antibody (E1L3 N clone; Cell...