A5051661724- Head and Neck Cancer Studies
- Advanced Radiotherapy Techniques
- Brain Metastases and Treatment
- Radiation Therapy and Dosimetry
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Lung Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Management of metastatic bone disease
- Head and Neck Surgical Oncology
- Radiomics and Machine Learning in Medical Imaging
- Meningioma and schwannoma management
- Neuroblastoma Research and Treatments
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Pancreatic and Hepatic Oncology Research
- Esophageal Cancer Research and Treatment
- Cancer Genomics and Diagnostics
- Sarcoma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Radiation Effects in Electronics
- Cancer and Skin Lesions
- Renal cell carcinoma treatment
- Nonmelanoma Skin Cancer Studies
University of Maryland, Baltimore
2020-2025
University of Maryland Upper Chesapeake Health
2023-2025
University of Maryland Medical System
2023-2024
Ghent University
2024
Lankenau Medical Center
2021
Virginia Cancer Specialists
2021
Emory University
2015-2019
Emory Clinic
2018
Emory Healthcare
2018
GTx (United States)
2018
Advances in the treatment of human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) include transoral robotic surgery (TORS) and proton beam therapy (PBT). This study aims to improve understanding toxicities associated with adjuvant PBT following TORS for OPSCC. A retrospective review. An academic tertiary care center Baltimore, Maryland. Patients undergoing followed by from 2017 2023 were reviewed. Forty-seven patients HPV-associated OPSCC underwent PBT....
Soft tissue sarcomas (STS) have minimal expression of PD-L1, a biomarker for PD-1 therapy efficacy. Radiotherapy (RT) has been shown to increase PD-L1 pre-clinically. We examined the pre- and post-RT, in 46 Stage II-III STS patients treated with pre-operative RT (50–50.4 Gy 25–28 fractions) followed by resection. Five additional who did not receive were utilized as controls. on biopsy resection samples was evaluated immunochemistry using anti monoclonal antibody (E1L3 N clone; Cell...
The optimal margin size in postoperative stereotactic radiosurgery (SRS) for brain metastases is unknown. Herein, the authors investigated effect of SRS planning target volume (PTV) on local recurrence and symptomatic radiation necrosis postoperatively.
Re-irradiation (re-RT) for recurrent head and neck cancer (rHNC) is challenging. We describe clinical outcomes toxicity of proton therapy (PT) HNC, report genomic alterations associated with patterns failure. performed a retrospective analysis rHNC patients treated PT. Outcomes were estimated using the Kaplan-Meier method. Univariate (UVA) multivariate analyses (MVA) to assess multiple patient factors. Next-generation sequencing on available samples. Eighty-nine PBS-PT median follow-up 12 mo...
The indications for adjuvant therapy in resected oral tongue cancers are based on both clinical and pathological factors, with clear evidence radiation patients pathologically positive neck lymph nodes, margins, extracapsular extension, but the data no nodal disease sparse.
Abstract BACKGROUND Brain metastases (BM) treated with surgical resection and focal postoperative radiotherapy have been associated an increased risk of subsequent leptomeningeal dissemination (LMD). BMs hemorrhagic and/or cystic features contain less solid components may therefore be at higher for tumor spillage during resection. OBJECTIVE To investigate the association between stereotactic radiosurgery LMD. METHODS One hundred thirty-four consecutive patients a single resected BM adjuvant...
This study addresses the limited noninvasive tools for Head and Neck Squamous Cell Carcinoma (HNSCC) progression-free survival (PFS) prediction by identifying Computed Tomography (CT)-based biomarkers predicting prognosis. A retrospective analysis was conducted on data from 203 HNSCC patients. An ensemble feature selection involving correlation analysis, univariate best-subset selection, LASSO-Cox algorithm used to select functional features, which were then build final Cox Proportional...
TPS283 Background: Some patients with oligometastases may have the potential for long-term disease-free survival just aggressive local therapy as shown by randomized trials total consolidation of macroscopic metastases using metastasis-directed (MDT). Long-term outcomes pooled STOMP and ORIOLE in oligorecurrent metastatic castration-sensitive prostate cancer (omCSPC) demonstrated MDT improved progression free survival. However, men high-risk mutations, including pathogenic alterations ATM ,...
ABSTRACT Objectives Nutritional outcomes following transoral robotic surgery (TORS) for human papillomavirus (HPV) associated oropharyngeal squamous cell carcinoma (OPSCC) are poorly understood. This study evaluates how TORS, with or without adjuvant treatment, impacts swallowing and weight loss. Methods All patients treated TORS HPV‐associated OPSCC from January 2016 to December 2023 were included. Weight loss, functional oral intake, feeding tube dependence, patient demographics, treatment...
Background and objectiveOligometastatic castration-sensitive prostate cancer (omCSPC) represents an early state in the progression of metastatic disease for which patients experience better outcomes comparison to those with higher burden. Despite generally more indolent nature, there is still much heterogeneity, some experiencing a aggressive clinical course unexplained by features alone. Our aim was investigate correlation tumor genomics mode (MOP) pattern failure (POF) following first...
Abstract Background Pathologic extranodal extension (ENE) has traditionally guided the management of head and neck cancers. The prognostic value radiographic ENE (rENE) in human papillomavirus (HPV)‐associated oropharyngeal squamous cell carcinoma (HPV + OPX) is uncertain. Methods Patients with HPV OPX adequate pretreatment nodal evaluation from a single institution were analyzed. rENE status was determined by neuroradiologists' at time diagnosis. Distant metastasis‐free survival (DMFS),...
Background Perioperative chemotherapy (POC) is one standard approach for the treatment of resectable cancers stomach and gastroesophageal junction (GEJ), whereas there has been growing interest in preoperative therapies. The objective current study was to compare survival between patients treated with chemoradiotherapy adjuvant (PCRT) those receiving POC using a large database. Methods National Cancer Data Base queried diagnosed 2004 2013 American Joint Committee on clinical group stage IB...
Single vocal cord irradiation (SVCI) is a promising technique to maintain excellent oncologic control and potentially improve upon toxicities for treatment of early-stage glottic squamous cell carcinomas. We sought investigate whether pencil beam scanning (PBS) proton therapy could the already favorable dose gradients demonstrated with volumetric modulated arc (VMAT) SVCI.
For the treatment of choroidal melanoma, palladium-103 (Pd) and ruthenium-106 (Ru) plaque brachytherapy shows reduced toxicity compared with historical standard iodine-125. No report has directly clinical outcomes between Pd Ru, reasons for selection one over other remain purely theoretical. Patients melanoma apical tumor height up to 5 mm were included. from Emory University treated 1993 2012. Cleveland Clinic Ru 2005 2010. Medical records retrospectively reviewed. We post-treatment visual...