A5035477951- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Polyomavirus and related diseases
- Advanced X-ray and CT Imaging
- Advanced Radiotherapy Techniques
- Antenna Design and Analysis
- Full-Duplex Wireless Communications
- Lung Cancer Treatments and Mutations
- Head and Neck Cancer Studies
- Bacteriophages and microbial interactions
- Plant Virus Research Studies
- Cancer Immunotherapy and Biomarkers
- AI in cancer detection
- Pituitary Gland Disorders and Treatments
- Glioma Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- MRI in cancer diagnosis
- Radiation Therapy and Dosimetry
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
- Esophageal Cancer Research and Treatment
- COVID-19 epidemiological studies
- Autism Spectrum Disorder Research
- Adrenal and Paraganglionic Tumors
University of Maryland, Baltimore
2024-2025
University of Washington
2016-2025
University of Cambridge
2025
Christian Medical College, Vellore
2007-2024
Christian Medical College
2007-2024
University of Maryland Medical Center
2024
Seattle University
2018-2019
University of Washington Medical Center
2017-2018
Vellore Institute of Technology University
2014-2017
Royal Gwent Hospital
2014
Understanding mechanisms of late/acquired cancer immunotherapy resistance is critical to improve outcomes; cellular trials offer a means probe complex tumor-immune interfaces through defined T cell/antigen interactions. We treated two patients with metastatic Merkel cell carcinoma autologous polyomavirus specific CD8+ cells and immune-checkpoint inhibitors. In both cases, dramatic remissions were associated dense infiltration activated CD8+s into the regressing tumors. However, late relapses...
<h3>Importance</h3> Merkel cell carcinoma (MCC) often behaves aggressively; however, disease-recurrence data are not captured in national databases, and it is unclear what proportion of patients with MCC experience a recurrence (estimates vary from 27%-77%). Stage-specific that includes time diagnosis would provide more precise prognostic information contribute to risk-appropriate clinical surveillance. <h3>Objective</h3> To estimate risk stage-specific mortality over since diagnosis....
Abstract Approximately one‐third of Merkel cell carcinoma (MCC) patients eventually develop distant metastatic disease. Little is known about whether the location primary lesion predictive initial site, or if survival likelihood differs depending on site. Such data could inform imaging/surveillance practices and improve prognostic accuracy. Multivariate competing‐risk analyses were performed a cohort 215 MCC with metastases, 31% whom had two more sites metastasis. At time metastasis in...
Merkel cell carcinoma (MCC) is an aggressive, high‐grade, cutaneous neuroendocrine tumour (NET). Agents blocking programmed death 1/programmed ligand 1 have efficacy in metastatic MCC (mMCC), but half of patients do not derive durable benefit. Somatostatin analogues (SSAs) are commonly used to treat low‐ and moderate‐grade NETs that express somatostatin receptors (SSTRs). To assess SSTR expression the SSAs mMCC, a high‐grade NET. Methods In this retrospective study 40 with was assessed...
There is an inequitable distribution of radiology facilities in India. This scoping review aimed at mapping the available technology instruments to improve access imaging primary health care; identify facilitators and barriers, knowledge gaps for widespread adaptation solutions. A search was conducted using broad inclusive terms non-specific subtypes medical devices or informatics. Work published English language between 2005 2022, primarily India, with full manuscripts were included. Two...
<h3>Background</h3> Immune checkpoint inhibitors (ICIs) are the treatment of choice for several cancers and can be associated with remarkable clinical benefit, but also cause serious immune-related adverse events (irAEs). Management rare severe irAEs is challenged by an incomplete knowledge their natural history pathogenetic mechanisms. We report a case fatal acute-onset gastro-intestinal (GI) hypomotility from myenteric plexus neuropathy following single dose ipilimumab plus nivolumab given...
BACKGROUND:Merkel cell carcinoma (MCC) is a rare but aggressive neuroendocrine skin cancer. The estimated 5-year survival of patients with metastatic disease approximately 14%. Cytotoxic chemotherapy associated modest median progression-free (PFS) only 3 months. In recent studies, immunotherapy anti-PD-1/anti-PD-L1 antibodies has demonstrated high response rate in immunocompetent (>50% chemotherapy-naïve patients) and responses are typically durable. However, 50% do not respond to...
Abstract Background: Immune checkpoint inhibitors (ICIs) have revolutionized treatment of advanced cutaneous melanoma by leveraging the host immune system to target and eliminate tumour cells. However, predictive biomarkers for clinical response ICIs remain elusive, limiting ability stratify patients effectively. The heterogeneity in outcomes, coupled with limited sensitivity timeliness radiographic assessments, particularly stable disease, underscores urgent need molecularly guided,...
This study addresses the limited noninvasive tools for Head and Neck Squamous Cell Carcinoma (HNSCC) progression-free survival (PFS) prediction by identifying Computed Tomography (CT)-based biomarkers predicting prognosis. A retrospective analysis was conducted on data from 203 HNSCC patients. An ensemble feature selection involving correlation analysis, univariate best-subset selection, LASSO-Cox algorithm used to select functional features, which were then build final Cox Proportional...
Abstract Thymic epithelial tumours (TETs) are rare and exhibit varied behaviour prognosis based on their histological subtype, as classified by the World Health Organization (WHO). These subtypes further categorized into low-risk high-risk groups. Low-risk thymomas generally allow for complete surgical resection without adjuvant therapy, while types often require multimodal treatment due to aggressive nature. This study aims evaluate role of CT radiomics in discriminating between high- TETs....
Patients undergoing chemoradiation and immune checkpoint inhibitor (ICI) therapy for locally advanced non-small cell lung cancer (NSCLC) experience pulmonary toxicity at higher rates than historical reports. Identifying biomarkers beyond conventional clinical factors radiation dosimetry is especially relevant in the modern immunotherapy era. We investigated role of novel functional radiomics, relative to characteristics, pneumonitis risk stratification NSCLC.
Purpose of the Report We evaluated reliability 18 F-FDG PET imaging biomarkers to classify early response status across observers, scanners, and reconstruction algorithms in support biologically adaptive radiation therapy for locally advanced non–small cell lung cancer. Patients Methods Thirty-one patients with unresectable cancer were prospectively enrolled on a phase 2 trial (NCT02773238) underwent GE Discovery STE (DSTE) or MI (DMI) PET/CT systems at baseline during third week external...
The effect of functional lung avoidance planning on radiation dose-dependent changes in regional perfusion is unknown. We characterized dose-perfusion response longitudinal single photon emission computed tomography (SPECT)/CT two cohorts cancer patients treated with and without techniques.The study included 28 primary patients: 20 from interventional (NCT02773238) (FLARE-RT) eight observational (NCT01982123) (LUNG-RT) clinical trials. FLARE-RT treatment plans perfused dose constraints while...
There are limited clinical data on scanning-beam proton therapy (SPT) in treating locally advanced lung cancer, as most published studies have used passive-scatter technology. is increasing interest whether the dosimetric advantages of SPT compared with photon can translate into superior outcomes. We present our experience and intensity modulated radiation (IMRT) dosimetry outcomes patients stage III cancer.
This paper presents an improved GrowCut (IGC), a positron emission tomography-based segmentation algorithm, and tests its clinical applicability. Contrary to the traditional method that requires user provide initial seeds, IGC algorithm starts with threshold-based estimate of tumor three-dimensional morphologically grown shell around as foreground background respectively. The repeatability from same observer at multiple time points was compared algorithm. tested in 11 nonsmall cell lung...
<h3>Objective</h3> The present study evaluates the concurrent and predictive validity of Seguin Form Board Test (SFBT) as an intelligence tool for children in low- middle-income countries. <h3>Methods</h3> In a cohort normal children, followed up South India, two cross-sectional analyses were done at 3 7 years age on 95 children. SFBT Vineland Social Maturity Scale (VSMS) Malin's Intelligence Indian Children (MISIC) VSMS age, results compared SFBT. <h3>Results</h3> quotient social had...
Radiomics involves the extraction of information from medical images that are not visible to human eye. There is evidence these features can be used for treatment stratification and outcome prediction. However, there much discussion about reproducibility results between different studies. This paper studies CT texture in radiomics, comparing two feature implementations, namely MATLAB toolkit Pyradiomics, when applied independent datasets scans patients: (i) open access RIDER dataset...
3044 Background: 80% of Merkel cell carcinomas (MCCs) are caused by polyomavirus (MCPyV) oncoproteins. Although absent in most cases, abundant MCPyV-specific CD8+ TIL associated with good MCC outcomes, implying tumor susceptibility to immune attack. Indeed, anti-PD-1 axis blockade has a response rate 32-56%. However, half patients do not respond, suggesting lack adequate T cells and/or evasion from MCC-related reduced HLA expression. We hypothesized the combination adoptive transfer...