A5066695915- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Epilepsy research and treatment
- Prion Diseases and Protein Misfolding
- Marine and coastal plant biology
- Ichthyology and Marine Biology
- Neuroinflammation and Neurodegeneration Mechanisms
- Coral and Marine Ecosystems Studies
- Traumatic Brain Injury Research
- Pharmacological Effects and Toxicity Studies
- Cellular transport and secretion
- Neurological Disease Mechanisms and Treatments
- Medicinal Plants and Neuroprotection
- Aquaculture disease management and microbiota
- Terrorism, Counterterrorism, and Political Violence
- Stroke Rehabilitation and Recovery
- Trace Elements in Health
- Pharmacogenetics and Drug Metabolism
- Anesthesia and Neurotoxicity Research
- Vibrio bacteria research studies
- Stress Responses and Cortisol
- Posttraumatic Stress Disorder Research
- Genetics and Neurodevelopmental Disorders
- Coordination Chemistry and Organometallics
- Cardiovascular Effects of Exercise
University of Washington
2024
Ovid Therapeutics (United States)
2022
New York University
2003-2017
Marinus Pharmaceuticals (United States)
2007-2017
Cornell University
1999-2000
Presbyterian Hospital
2000
New York Hospital Queens
2000
NewYork–Presbyterian Hospital
2000
Rockefeller University
1999
University of Chicago
1999
The excessive generation and accumulation of 40- 42-aa beta-amyloid peptides (Abeta40/Abeta42) in selectively vulnerable brain regions is a major neuropathological feature Alzheimer's disease. Abeta, derived by proteolytic cleavage from the precursor protein (betaAPP), normally secreted. However, recent evidence suggests that significant levels Abeta also may remain inside cells. Here, we have investigated subcellular compartments within which distinct amyloid species are generated they...
Microglia are known as resident immune cells in the brain. β-amyloid (Aβ) plaques brain of Alzheimer's disease (AD) surrounded by microglia, but whether and how microglia affect formation maintenance remains controversial. We depleted injecting diphtheria toxin (DT) CX 3 CR1 CreER/+ :R26 DTR/+ (CX CR1-iDTR) mice crossed with APPswe/PSEN1dE9 (APP/PS1) mice. Intravital time-lapse imaging was performed to examine changes number size Congo Red-labeled amyloid over 1–2 weeks. also examined spine...
OBJECTIVE To determine whether the cognitive status of professional football players varies as a function age and apolipoprotein E (APOE) genotype. METHODS Fifty-three active underwent APOE neuropsychological assessments. Players were grouped according to (proxy indicator high/low exposure contact) presence/absence at least one copy ε4 allele. Outcome measures overall performance scores in domains. RESULTS As group, older possessing exhibited significantly lower test than did all other...
Abstract: Dystrophic neurites are associated with fibrillar amyloid deposition in Alzheimer's disease (AD), but the frequency and types of changes synaptic structures near deposits have not been well characterized. Using high‐resolution confocal microscopy to image lipophilic dye‐labeled dendrites thioflavin‐S‐labeled plaques, we systematically analyzed structural both a transgenic mouse model AD (PSAPP) human postmortem brain. We found that PSAPP mice, dendritic branches passing through or...
Abstract Strong evidence supports that CNS-specific CD4+ T cells are central to the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). Using a model spontaneous EAE, we demonstrated myelin basic protein (MBP)-specific up-regulate activation markers in CNS-draining cervical lymph nodes at time when there is no cell anywhere else, including CNS, before appearance clinical signs. In number MBP-specific numbers does not build up gradually CNS; instead, swift...
A pilot study of the safety, tolerability, dose range and potential efficacy ganaxolone for treatment refractory epilepsy in pediatric adolescent subjects.We report results a nonrandomized, nonblinded, open-label, dose-escalation trial subjects (5-15 years) suffering from epilepsy. Subjects received an oral suspension 1:1 complex with beta-cyclodextrin escalation (1 mg/kg, b.i.d. to 12 mg/kg t.i.d.) schedule over 16 days. This was followed by maintenance period 8 weeks. that showed...
Summary Objective To evaluate the efficacy and safety of ganaxolone as adjunctive therapy in adults with uncontrolled partial‐onset seizures despite taking up to three concomitant antiepileptic drugs ( AED s). Methods Adults aged 18–69 years refractory conventional s were enrolled a multicenter, double‐blind, placebo‐controlled trial. After an 8‐week baseline period, patients randomized 2:1 1,500 mg/day or placebo for 10‐week treatment period (2‐week forced titration maintenance) followed by...
Biofluorescence exists in only a few classes of organisms, with Anthozoa possessing the majority species known to express fluorescent proteins. Most within Anthozoan subgroup Scleractinia (reef-building corals) not green proteins, they also localize proteins distinct anatomical patterns.We examined distribution biofluorescence 33 coral species, representing 8 families, from study sites on Australia's Great Barrier Reef. For 28 these we report presence for first time. The dominant emissions...
The diagnosis of prion diseases in humans is challenging due to a lack specific and sensitive non-invasive tests. Many forms human disease including variant Creutzfeldt-Jakob (vCJD), Gerstmann-Sträussler-Scheinker (GSS) syndrome, 10% sporadic CJD cases are associated with amyloid deposition. Several positron emission tomography (PET) ligands have recently been developed directly image β-amyloid Alzheimer disease. One them, methoxy-X04, fluorescent derivative Congo red high binding affinity...
Drug treatment for children with epilepsy should, ideally, be governed by evidence from adequate and well-controlled clinical studies. However, these studies are difficult to conduct, so direct supporting the informed use of specific drugs is often lacking. The Research Roundtable Epilepsy (RRE) met in 2020 align on an approach therapy development focal seizures age 1 month <2 years age.The RRE reviewed regulatory landscape, epidemiology, seizure semiology, antiseizure medicine pharmacology,...
To assess ganaxolone as adjunctive therapy in drug-resistant focal-onset seizures
ABSTRACT Pharmaceutical-grade medium chain triglycerides (MCTs) are common excipients for in vivo pharmacological studies laboratory animals, and as an experimental therapeutic certain metabolic neurological disorders. In this study, we examined the tolerability of repeated administration a pharmaceutical-grade formulation three MCTs—caprylic, capric, lauric acid - mice via oral (PO) intraperitoneal (IP) routes. We administered either 8 or 4 µL 100% MCTs saline/gram body weight twice daily...
Extended abstract of a paper presented at Microscopy and Microanalysis 2004 in Savannah, Georgia, USA, August 1–5, 2004.
OBJECTIVE: To test IV ganaxolone in a clinically translatable rodent model of status epilepticus (SE). BACKGROUND: Ganaxolone (GNX) is synthetic analog the endogenous neurosteroid GABA modulator allopregnanolone (ALLO) and development for treatment epilepsy other neuropsychiatric conditions. DESIGN/METHODS: Convulsive SE (CSE) was induced by administration lithium chloride pilocarpine to male Sprague-Dawley rats. GNX (6, 9, 12 mg/kg) or ALLO (15 were administered via bolus injections at time...
Objective: These studies were designed to evaluate the potential of ganaxolone (GNX) for treatment status epilepticus (SE). Further conducted clarify activities GNX on human progesterone (PGR) receptor. Background: Ganaxolone is an analog neurosteroid GABA modulator allopregnanolone (ALLO) and in development epilepsy. Methods: SE was induced by lithium chloride pilocarpine administration Sprague-Dawley rats. Seizure response measured electroencephalographic recordings through cortical...
OBJECTIVE: To test IV ganaxolone in a clinically translatable rodent model of status epilepticus (SE). BACKGROUND: Ganaxolone (GNX) is synthetic analog the endogenous neurosteroid GABA modulator allopregnanolone (ALLO) and development for treatment epilepsy other neuropsychiatric conditions. DESIGN/METHODS: Convulsive SE (CSE) was induced by administration lithium chloride pilocarpine to male Sprague-Dawley rats. GNX (6, 9, 12 mg/kg) or ALLO (15 were administered via bolus injections at time...
To evaluate the safety and efficacy of ganaxolone (GNX) for treatment anxiety attention in subjects with fragile X syndrome (FXS).