A5075091950- Heme Oxygenase-1 and Carbon Monoxide
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Response and Inflammation
- Respiratory Support and Mechanisms
- Craniofacial Disorders and Treatments
- S100 Proteins and Annexins
- Alcohol Consumption and Health Effects
- Cleft Lip and Palate Research
- Bone Metabolism and Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Pluripotent Stem Cells Research
- Pain Mechanisms and Treatments
- Autophagy in Disease and Therapy
- Neuroscience of respiration and sleep
- Neurobiology and Insect Physiology Research
- Medicinal Plants and Bioactive Compounds
- Neuroscience and Neuropharmacology Research
- Advanced Glycation End Products research
- Tissue Engineering and Regenerative Medicine
- Lipid metabolism and disorders
- Endoplasmic Reticulum Stress and Disease
- Insect Utilization and Effects
- Medical and Biological Sciences
- Neonatal Respiratory Health Research
- Immune cells in cancer
Peking University Third Hospital
2011-2025
Peking University
2011-2025
Guangzhou Medical University
2024
People's Liberation Army 401 Hospital
2023
China National Rice Research Institute
2020-2023
Hunan Provincial Maternal and Child Health Hospital
2018
Xiamen University
2015
Shanghai Pulmonary Hospital
2014
Tongji University
2014
Chinese Academy of Agricultural Sciences
2013-2014
The potential of relapse craniofacial disharmony after trans-sutural distraction osteogenesis is high due to the failure produce a stable bone bridge in suture gap. aim this study evaluate whether hydroxyapatite nanoparticles (nHAP) have effect promoting osteoblast differentiation suture-derived stem cells (SuSCs) and formation sagittal during expansion.SuSCs were isolated from sutures exposed various concentrations nHAP (0, 25, 50, 100 μg mL-1) determine optimal concentration via performing...
Green vegetables are thought to have a chemoprotective effect on the basis of epidemiologic evidence. This study investigated whether chlorophyllin (CHL) could induce antioxidant enzymes and confer protection against oxidative damage. The results showed that CHL HO-1 NQO1 expression in human umbilical vein endothelial cell (HUVEC) time- dose-dependent manner protect them hydrogen peroxide caused induction by was accompanied with accumulation transcription factor Nrf2 nucleus activation...
Autophagy is a potentially inimical pathway and together with apoptosis, may be activated by similar stress stimuli that can lead to cell death. The molecular cues dictate the fate choice between autophagy apoptosis remain largely unknown. Here we report proapoptotic protein BBC3/PUMA (BCL2 binding component 3) bona fide substrate of chaperone-mediated (CMA). BBC3 associates HSPA8/HSC70 (heat shock 70kDa 8), leading its lysosome translocation uptake. Inhibition CMA results in stabilization...
Abstract Background: Systemic inflammation is a key feature in acid aspiration-induced acute respiratory distress syndrome (ARDS), but the factors that trigger are unclear. The authors hypothesize extracellular histones, newly identified inflammatory mediator, play important roles pathogenesis of ARDS. Methods: used hydrochloric ARDS model to investigate whether histones pathogenic and targeting protective. Exogenous antihistone antibody were administered mice. Heparin can bind so studied...
This study investigated pathogenic role and mechanism of extracellular histone H4 during oleic acid (OA)-induced acute respiratory distress syndrome (ARDS). Methods: ARDS was induced by intravenous injection OA in mice, evaluated blood gas, pathological analysis, lung edema, survival rate. Heparan sulfate (HS) degradation using immunofluorescence flow cytometry. The released von Willebrand factor (vWF) measured ELISA. P-selectin translocation neutrophil infiltration were via...
During the acute respiratory distress syndrome (ARDS), neutrophils play a central role in pathogenesis, and their activation requires interaction with endothelium. Extracellular histones have been recognized as pivotal inflammatory mediators. This study was to investigate of pulmonary endothelial during extracellular histone-induced response ARDS. ARDS induced male C57BL/6 mice by intravenous injection lipopolysaccharide (LPS) or exogenous histones. Concurrent LPS administration,...
It was previously thought that the odorant binding proteins (OBPs) in sensillum lymph might serve as carriers, which could carry lipophilic molecules to olfactory receptors. In this study, two novel OBP genes of scarab beetle Holotrichia oblita were screened using an antennal cDNA library. The full HoblOBP3 and HoblOBP4 cloned reverse transcription PCR rapid amplification ends. Homology modeling both OBPs performed SWISS-MODEL on-line tools. Next, expressed Escherichia coli purified Ni ion...
Chemosensory proteins (CSPs) play important roles in chemical communication by insects, as they recognize and transport environmental signals to receptors within sensilla. In this study, we identified HoblCSP1 HoblCSP2 from a cDNA library of Holotrichia oblita antennae, successfully expressed them E. coli purified Ni ion affinity chromatography. We then measured the ligand-binding specificities 50 selected ligands competitive binding assay. These results demonstrated that have similar...
BACKGROUND: Neuropathic pain is an intractable and complex disease. Recent studies have shown a close relationship between endoplasmic reticulum (ER) stress neuropathic pain. Here, we investigated the effect of α-asarone, ER inhibitor, on chronic constriction injury (CCI)–induced METHODS: Two parts were included in this study. In part 1, rats assigned to 7 groups: sham group, + α-asarone 20 mg/kg CCI vehicle 5 10 group. After surgery, treated with or normal saline daily. Pain thresholds...
Acute lung injury (ALI) is the leading cause of death in intensive care units. Extracellular histones have recently been recognized to be pivotal inflammatory mediators. Heparin and its derivatives can bind through electrostatic interaction. The purpose this study was investigate 1) role extracellular pathogenesis ALI caused by acid aspiration 2) whether N-acetyl-heparin (NAH) provides more protection than heparin against at high dose. induced mice via intratracheal instillation hydrochloric...
To clarify the genetic mechanism underlying grain protein content (GPC) and to improve rice qualities, mapping cloning of quantitative trait loci (QTLs) controlling natural variation GPC are very important. Based on genotyping-by-resequencing, a total 14 QTLs were detected with Huanghuazhan/Jizi1560 (HHZ/JZ1560) recombinant inbred line (RIL) population in 2016 2017. Seven fourteen repeatedly identified across two years. Using three residual heterozygote-derived populations, stably inherited...
Abstract Background Heparan sulfate (HS) degradation mediates pulmonary endothelial hyper-permeability and acute edema during respiratory distress syndrome (ARDS). The aim of this study was to examine whether histone H4 induced HS by activating heparanase (HPSE) in chlorine gas (Cl 2 )-induced ARDS. Methods Acute lung injury Cl exposure or injection C57BL/6 mice. Histone bronchoalveolar lavage fluid (BALF) plasma measured ELISA. immunostaining, ELISA, flow cytometry. HPSE mRNA protein were...
hESCs (human embryonic stem cells) can differentiate into tissue derivatives of all three germ layers in vitro and mimic the development embryo vivo. In this study, we have investigated potential an hESC-based assay for detection toxicity to cardiac differentiation development. First all, developed protocol induction from according our previous work distinguished precursor cells late mature cardiomyocytes differentiated cells, demonstrated by Q-PCR (quantitative real-time PCR),...
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) manifests as non-cardiogenic pulmonary edema, and refractory hypoxemia, which is caused by increased permeabili...
Abstract Background Chlorine gas (Cl 2 ) exposure remains a public health concern in household, occupational, and transportation accidents around the world. The death rate associated with acute respiratory distress syndrome (ARDS) caused by high concentrations of Cl is very high, mainly because pathogenesis ARDS unclear. Histone H4 has been identified as an important endogenous pro-inflammatory molecule. present study aimed to examine pathogenic role histone -induced ARDS. Methods was...