A5101463214- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Molecular Biology Techniques and Applications
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Circular RNAs in diseases
- Forensic and Genetic Research
- Cancer Research and Treatments
- Acute Myeloid Leukemia Research
- T-cell and B-cell Immunology
- RNA Interference and Gene Delivery
- Migraine and Headache Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Bone and Dental Protein Studies
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Phytochemicals and Antioxidant Activities
- CAR-T cell therapy research
- Lung Cancer Research Studies
- Galectins and Cancer Biology
- Angiogenesis and VEGF in Cancer
Ningxia Medical University
2023-2025
Sichuan Academy of Forestry
2023-2024
Sichuan Agricultural University
2023-2024
Beijing University of Technology
2024
First Hospital of Qinhuangdao
2012-2024
Bristol-Myers Squibb (United States)
2020-2024
Nanjing University of Science and Technology
2024
Macquarie University
2021-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Beihang University
2024
Abstract Acute liver failure (ALF) is a life-threatening systemic disorder. Here we investigated the impact of circulating histones, recently identified inflammatory mediators, on inflammation and injury in murine models patients with ALF. We analyzed histone levels blood samples from 62 ALF, 60 chronic disease, 30 healthy volunteers. incubated patients' sera human L02 hepatocytes monocytic U937 cells to assess cellular damage cytokine production. d -galactosamine plus lipopolysaccharide...
Abstract Background: Systemic inflammation is a key feature in acid aspiration-induced acute respiratory distress syndrome (ARDS), but the factors that trigger are unclear. The authors hypothesize extracellular histones, newly identified inflammatory mediator, play important roles pathogenesis of ARDS. Methods: used hydrochloric ARDS model to investigate whether histones pathogenic and targeting protective. Exogenous antihistone antibody were administered mice. Heparin can bind so studied...
Abstract Sustained intratumoral delivery of interleukin-12 (IL-12) and granulocyte macrophage colony-stimulating factor induces tumor regression via restoration tumor-resident CD8+ T-effector/memory cell cytotoxicity subsequent repriming a secondary T-effector response in tumor-draining lymph nodes (TDLN). However, treatment-induced activity is transient accompanied with CD4+ CD25+ Foxp3+ T-suppressor rebound. Molecular cellular changes posttherapy microenvironment TDLN were monitored to...
MicroRNAs might act as oncogenes or tumor suppressors in cancer. Recent studies have shown that miR-421 is up-regulated human gastric Here, we found was over-expressed cancer tissues and cell lines. Bioinformatics analysis predicted the caspase-3 gene a target of miR-421. Caspase-3 negatively regulated by at post-transcriptional level. Bax Bcl-2 were also Moreover, necrosis factor receptor-I -II, death receptors apoptosis pathway, The over-expression promoted growth inhibited BGC-823 line....
This study aimed to investigate the protective effects of echinacoside, one phenylethanoids isolated from stems Cistanche salsa, a Chinese herbal medicine, on D-galactosamine (GalN) and lipopolysaccharide (LPS)-induced acute liver injury in mice.We administered GalN (650 mg/kg) together with LPS (30 μg/kg) mice by intraperitoneal injection induce damage. Echinacoside (60 was given intraperitoneally at 1 h prior GalN/LPS exposure. Mice were sacrificed different time points following...
Abstract Diets rich in fat, smoking, as well exposure to environmental pollutants and dysbiosis of gut microbiota, increase the risk developing colorectal cancer. Much progress has been made combating However, options for chemoprevention from insult microbiota remain elusive. We investigated influence berry-derived anthocyanidins (Anthos), with without encapsulating them bovine milk–derived exosomes (ExoAnthos), on bacteria-driven colon tumor development. Anthos ExoAnthos treatment cancer...
Sustained delivery of IL-12 and GM-CSF to tumors induces the activation tumor-resident CD8(+) T effector/memory cells (Tem) followed by cytotoxic effector cell expansion. To determine whether secondary effectors expanded from tumor-associated Tem or were primed de novo, kinetics tumor-draining lymph node (TDLN) analyzed. Treatment promoted a 4-fold increase in numbers TDLN displaying CD69(+)CCR5(+)CD62L(-) periphery-homing phenotype day 4 posttherapy. Pulse labeling tumor with BrdU confirmed...
Tanshinone IIA is a natural extract derived from Chinese medicinal herb with multiple bioactivities; however, whether and how tanshinone protects against colorectal cancer (CRC) are uncertain.We investigated the potential beneficial effects of in colitis-associated tumorigenesis mouse model its underlying mechanisms.Male C57BL/6 mice were treated azoxymethane (AOM) 10 mg/kg body weight dextran sulphate sodium (2.5% DSS) to induce model. (200 weight) was given intraperitoneally. After 12...
The passive WiFi sensing research has largely centered on activity using fixed-location transceivers, leading to the development of several theoretical models that aim map received signals human activity. Of these models, Fresnel zone model shown be particularly noteworthy. However, growing popularity mobile receivers not been matched by corresponding receiver-based models. This paper fills this gap presenting first quantify impact moving a receiver for sensing. We propose novel dynamic in...
Tumor-resident CD8(+) T cells display a quiescent effector/memory phenotype that is maintained in part by infiltrating CD4(+) CD25(+) Foxp3(+) T-suppressor cells. Intratumoral delivery of IL-12, contrast, can restore cytotoxic function to tumor-associated and induce the apoptotic death Depletion from tumors before IL-12 treatment resulted abrogation treatment-mediated cell apoptosis revealing link between activation elimination. Furthermore, failed loss IFN-gamma- or FasL-deficient mice...
To investigate the effects of miR-106b on malignant characteristics gastric cancer cells, and explore possible mechanisms.Expression miR-106b, p21 E2F was determined by real-time PCR. Transfection with mimics conducted, cells overexpression were obtained. Cells transfected mimic mutants those without transfection served as negative blank controls, respectively. Flow cytometry transwell assays adopted to detect cell cycle, migration invasion cells.. The expression miR- 106b in significantly...
Acupuncture has been proven to be effective as an alternative therapy in treating migraine, but the pathophysiological mechanisms of treatment remain unclear. This study investigated possible neurochemical responses acupuncture treatment.Proton magnetic resonance spectroscopy imaging was used investigate biochemical levels pre- and post-acupuncture treatment. Participants (N=45) included subjects diagnosed with: 1) migraine without aura; 2) cervicogenic headache; 3) healthy controls. two...
Up-regulation of UHRF1 has been observed in a variety cancers and appears to serve as an independent prognostic factor.To explore the effect gene silencing on apoptosis proliferation cervical squamous cell carcinoma (CSCC) CaSki cells.This study consisted 47 CSCC tissues 40 normal tissues. The cells were assigned into Blank group (CaSki not transfected), NC transfected with control siRNA), Silence siRNA). qRT-PCR Western blot used for mRNA protein expressions, CKK-8 assay proliferation, flow...
This study aimed at exploring the role of microRNA-21 (miR-21) in predicting brain metastases (BM) from non-small cell lung cancer (NSCLC).A total 132 NSCLC patients, including 68 patients with BM and 64 without BM, were included study. cells collected assigned to inhibitor (IN) group, mock negative control (NC) group. The quantitative real-time polymerase chain reaction assay was used detect miR-21 expression. Cell proliferation, migration, invasion, apoptosis detected by colony-forming...
To investigate the metabolite concentration ratios including N-acetylaspartate (NAA), choline-containing compounds (Cho) and creatine plus phosphocreatine (Cr) in thalami of patients with migraine without aura, trigeminal neuralgia healthy comparison subjects using multi-voxel proton magnetic resonance spectroscopy (1H-MRS).1H-MRS was performed a 3.0 T MR system on thalamus bilaterally 20 16 14 control subjects.In neuralgia, except for Cho/Cr were different from those (p>0.05). In group,...