A5101595701- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Galectins and Cancer Biology
- Traditional Chinese Medicine Analysis
- Dermatology and Skin Diseases
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Cancer Mechanisms and Therapy
- Cytokine Signaling Pathways and Interactions
- Cancer-related molecular mechanisms research
- Food Allergy and Anaphylaxis Research
- Pancreatic and Hepatic Oncology Research
- Enzyme Catalysis and Immobilization
- Angiogenesis and VEGF in Cancer
- Lung Cancer Treatments and Mutations
- Allergic Rhinitis and Sensitization
- Biochemical Acid Research Studies
- Inflammasome and immune disorders
- Colorectal Cancer Treatments and Studies
- Ion channel regulation and function
- Cancer Treatment and Pharmacology
- HIV/AIDS drug development and treatment
- Autophagy in Disease and Therapy
- Asthma and respiratory diseases
- Virus-based gene therapy research
Tongji University
2016-2025
Shanghai Tenth People's Hospital
2016-2025
Qilu University of Technology
2025
Shandong Academy of Sciences
2025
Eli Lilly (United States)
2018-2024
Anhui University of Traditional Chinese Medicine
2013-2024
Central South University
2022-2024
Xiangya Hospital Central South University
2024
Second Xiangya Hospital of Central South University
2023
Merck & Co., Inc., Rahway, NJ, USA (United States)
2013-2023
Lebrikizumab, a high-affinity IgG4 monoclonal antibody targeting interleukin-13, prevents the formation of interleukin-4Rα-interleukin-13Rα1 heterodimer receptor signaling complex.We conducted two identically designed, 52-week, randomized, double-blind, placebo-controlled, phase 3 trials; both trials included 16-week induction period and 36-week maintenance period. Eligible patients with moderate-to-severe atopic dermatitis (adults [≥18 years age] adolescents [12 to <18 age, weighing ≥40...
Abstract Background Lebrikizumab is a novel, high-affinity monoclonal antibody that selectively binds to interleukin (IL)-13. Objectives To evaluate the efficacy and safety of lebrikizumab monotherapy in adolescent adult patients with moderate-to-severe atopic dermatitis (AD) over 52 weeks treatment ADvocate1 (NCT04146363) ADvocate2 (NCT04178967). Methods Patients who responded 250 mg every 2 (Q2W) at end 16-week induction period were re-randomized : 1 receive Q2W, 4 (Q4W) or placebo Q2W...
The adequate stimuli and molecular receptors for muscle metaboreceptors nociceptors are still under investigation. We used calcium imaging of cultured primary sensory dorsal root ganglion (DRG) neurons from C57Bl/6 mice to determine candidates metabolites that could be the detect these stimuli. Retrograde DiI labeling determined some innervated skeletal muscle. found combinations protons, ATP, lactate were much more effective than individually applied compounds activating rapid increases in...
No animal models replicate the complexity of human depression. However, a number behavioral tests in rodents are sensitive to antidepressants and may thus tap important underlying biological factors. Such also offer best opportunity discover novel treatments. Here, we used several these test hypothesis that acid-sensing ion channel-1a (ASIC1a) might be targeted reduce Genetically disrupting ASIC1a mice produced antidepressant-like effects forced swim test, tail suspension following...
This study examined the extent to which posthospitalization change in connectedness with family, peers, and nonfamily adults predicted suicide attempts, severity of suicidal ideation, depressive symptoms across a 12-month follow-up period among inpatient adolescents. Participants were 338 adolescents, ages 13 17, who assessed at 3, 6, 12 months posthospitalization. General liner models fitted for ideation outcomes, logistic regression was used dichotomous attempt outcome. The moderating...
Purpose: Regulatory T (Treg) cells are important suppressive among tumor-infiltrating lymphocytes (TIL). Treg express the well-known immune checkpoint receptor PD-1, which is reported to mark "exhausted" with lower function. T-cell immunoglobulin mucin (Tim)-3, a negative regulator of Th1 immunity, expressed by sizeable fraction TIL Tregs, but functional status Tim-3+ Tregs remains unclear.Experimental Design: CD4+CTLA-4+CD25high were sorted from freshly excised head and neck squamous cell...
Objective: Taohong Siwu decoction (THSWD) is one of the classic prescriptions for promoting blood circulation and removing stasis, it has a good therapeutic effect on ischemic stroke. We sought to explore effects THSWD pyroptosis in rats with middle cerebral artery occlusion-reperfusion (MCAO/R). Methods: MCAO/R model were established by suture-occluded method. randomly divided into five groups, which group, nimodipine high, medium low dose group (18, 9, 4.5 g/kg, respectively), sham without...
Objective: Globally, cerebral ischemia has been shown to be the second leading cause of death. Our previous studies have that Taohong Siwu Decoction (THSWD) exhibits obvious neuroprotective effects on ischemia/reperfusion (I/R) injury (CIRI). In this study, we further explored modulatory effect THSWD mitochondrial autophagy in CIRI and relationship between NLRP3 inflammatory vesicle activation, so as explain mechanism THSWD. Methods: Middle artery occlusion reperfusion (MCAO/R) model rats...
Abstract Described here is an efficient stereoselective synthesis of vibegron enabled by enzymatic dynamic kinetic reduction that proceeds in a high‐pH environment. To overcome enzyme performance limitations under these conditions, ketoreductase was evolved computationally and structurally aided strategy to increase cofactor stability through tighter binding.
Currently, the biological understanding of Crohn's disease (CD) remains limited. PANoptosis is a revolutionary form cell death reported to participate in numerous diseases, including CD. In our study, we aimed uncover roles Differentially expressed PANoptosis-related genes (DE-PRGs) were identified by overlapping and differentially between CD normal samples combined microarray dataset. Three machine learning algorithms adopted detect hub DE-PRGs. To stratify heterogeneity within patients,...
Atopic dermatitis (AD) affects multiple areas of the body, some which may be more refractory to treatment. We evaluated improvements in Eczema Area and Severity Index (EASI) by body region clinical signs for each lebrikizumab-treated patients with moderate-to-severe AD. ADvocate 1 2 compared lebrikizumab 250 mg as monotherapy every weeks versus placebo 16 weeks. Efficacy measures included EASI, rates extent severity four (erythema, edema/papulation, excoriation, lichenification) regions...
To attenuate the safety, food spoilage and growing eco-friendly concerns cauesed by platics used in packaging, green degradable materials with antimicrobial high barrier properties are critical. Herein, a bacterial cellulose/polyvinyl alcohol based packaging film (PBPT) high-barrier, excellent property UV resistance was devoloped for preservation. Bacterial cellulose (BC) to improve gas performance hydrogen bonding interactions situ induced crystallization of polyvinyl (PVA) composites. TiO2...
246 Background: Regimen of metastatic colon cancer (mCOAD) is moving towards combination immune checkpoint inhibitors (ICBs) and targeted therapy, however ICBs are rarely effective in MSI-L cancers, limiting options for backline treatments, new therapy on demand to improve immunogenicity mCOAD. As targeting fatty acid metabolism or cell cycle has shown potential improving the efficacy ICBs, our team focused CTMP, a thioesterase (ACOT) family member, mainly modulates β oxidation, meanwhile it...
240 Background: SDC2 gene encodes the transmembrane proteoglycan molecule Syndecan-2. Syndecan-2 protein affects proliferation, migration and invasion of colorectal cancer cells by participating in regulation cell adhesion, tissue differentiation angiogenesis. Plasma methylated SEPTIN9 has been shown to be a sensitive specific biomarker for detection CRC, which is involved apoptosis, pseudopod projection, tumor invasion. The aim this study validate value S9 methylation diagnosis efficacy...
Federated learning allows multiple clients to collaboratively train a global model with the assistance of server. However, its distributed nature makes it susceptible poisoning attacks, where malicious can compromise by sending harmful local updates To unlearn an accurate from poisoned one after identifying clients, federated unlearning has been introduced. Yet, current research on primarily concentrated effectiveness and efficiency, overlooking security challenges presents. In this work, we...