A5074411325- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Galectins and Cancer Biology
- Lung Cancer Research Studies
- Immune cells in cancer
- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- interferon and immune responses
- Pancreatic and Hepatic Oncology Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immune Response and Inflammation
- Lymphoma Diagnosis and Treatment
- Inflammation biomarkers and pathways
- Radiopharmaceutical Chemistry and Applications
- Cancer Mechanisms and Therapy
- Neuroblastoma Research and Treatments
- Neuroendocrine Tumor Research Advances
- Tracheal and airway disorders
- Adrenal and Paraganglionic Tumors
- Lung Cancer Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Tsinghua University
2016-2022
Peking Union Medical College Hospital
2019-2022
University of Pittsburgh
2016-2018
UPMC Hillman Cancer Center
2015-2017
University of Pittsburgh Medical Center
2016
Programmed Death 1 (PD-1) and T cell Ig mucin domain-3 protein (Tim-3) are immune checkpoint receptors that expressed on tumor-infiltrating lymphocytes (TIL) in tumor-bearing mice humans. As anti-PD-1 single agent response rates only <20% head neck squamous carcinoma (HNSCC) patients, it is important to understand how multiple inhibitory maintain suppressed cellular immunity. One such receptor, Tim-3, activates downstream proliferative pathways through Akt/S6, highly dysfunctional TIL. We...
Improved understanding of expression immune checkpoint receptors (ICR) on tumor-infiltrating lymphocytes (TIL) may facilitate more effective immunotherapy in head and neck cancer (HNC) patients. A higher frequency PD-1+ TIL has been reported human papillomavirus (HPV)+ HNC patients, despite the role PD-1 T-cell exhaustion. This discordance led us to hypothesize that extent accurately defines function prognostic impact, because PD-1high T cells be exhausted than PD-1low influence clinical...
Purpose: Regulatory T (Treg) cells are important suppressive among tumor-infiltrating lymphocytes (TIL). Treg express the well-known immune checkpoint receptor PD-1, which is reported to mark "exhausted" with lower function. T-cell immunoglobulin mucin (Tim)-3, a negative regulator of Th1 immunity, expressed by sizeable fraction TIL Tregs, but functional status Tim-3+ Tregs remains unclear.Experimental Design: CD4+CTLA-4+CD25high were sorted from freshly excised head and neck squamous cell...
Abstract Purpose: The response rate of patients with head and neck squamous cell carcinoma (HNSCC) to cetuximab therapy is only 15% 20%, despite frequent EGFR overexpression. Because immunosuppression common in HNSCC, we hypothesized that adding a proinflammatory TLR8 agonist might result enhanced T-lymphocyte stimulation anti–EGFR-specific priming. Experimental Design: Fourteen previously untreated HNSCC were enrolled this neoadjuvant trial treated preoperatively 3 4 weekly doses motolimod...
The intracellular DNA sensor stimulator of interferon genes (STING) has recently been shown to play a vital role in anti-viral and anti-tumor immune responses stimulating cytokine production. While human papillomavirus (HPV) is causative agent for subset head neck squamous cell carcinoma (HNSCC) with unique etiology clinical outcome, how the STING pathway regulated virus-induced tumor microenvironment not well understood. Since inactivation likely reflects immunoescape via innate immunity,...
Programmed Death 1 (PD-1) and T cell Ig mucin domain-3 protein (Tim-3) are immune checkpoint receptors highly expressed on tumor infiltrating lymphocytes (TIL). PD-1 inhibits activation type-1 responses, while Tim-3 is proposed to mark more extensively exhausted cells, although the mechanisms underlying function not clear. Trials of anti-PD-1 therapy have identified a large subset non-responder patients, likely due expression alternative molecules like Tim-3. We investigated phenotypic...
ABSTRACT The role of T cell receptor (TCR) signaling for adaptive immune responses is essential. ability to respond a broad spectrum tumor antigens requires an selection various TCR. So far, little known about the TCR richness and clonality in cellular response head neck cancer (HNC), though Endothelial Growth Factor Receptor (EGFR)-specific CD8+ can be enhanced by cetuximab therapy. Therefore, we investigated differences sequences between human papillomavirus (HPV)+ HPV− HNC patients, as...
Purpose This study aims to investigate the prognostic value of composition and spatial architecture tumor-infiltrating lymphocytes (TILs) as well PDL1 expression on TILs subpopulations in nasopharyngeal carcinoma (NPC). Methods A total 121 patients with NPC were included divided into two groups: favorable (n = 68) unfavorable 53). The archived tumor tissues retrieved, a tissue microarray was constructed. density distribution infiltration analyzed using multiplex fluorescent...
Lymph node ratio (LNR) has been increasingly reported as a prognostic factor in oral cavity squamous cell carcinoma (OCSCC). This study aimed to develop and validate nomogram integrating LNR further assess its role guiding adjuvant therapy for OCSCC.A total of 8703 OCSCC patients treated primarily with surgery the Surveillance, Epidemiology End Results (SEER) database were retrieved randomly divided into training validation cohorts. The was created based on factors identified by Cox model....
Abstract Background Consolidative thoracic radiotherapy (cTRT) has previously shown benefit to patients with extensive stage small cell lung cancer (ES‐SCLC) who respond chemotherapy. However, the optimum dose of cTRT is unknown. The purpose this randomized trial compare efficacy 45 Gy in 15 fractions 30 10 ES‐SCLC. Methods This phase III, multicenter, designed evaluate safety and different Eligible pathologically confirmed ES‐SCLC responded 4–6 cycles etoposide plus cisplatin (EP) or...
Meeting abstracts Programmed Death 1 (PD-1) and T cell Ig mucin domain-3 protein (Tim-3) are immune check point receptors that upregulated on tumor infiltrating lymphocytes (TIL) in tumor-bearing mice humans. As anti-PD-1 single agent response rates still relatively low (20%) HNC
PURPOSE To develop and validate a nomogram integrating lymph node ratio (LNR) to predict cancer-specific survival (CSS) assist decision making for postoperative management in nonmetastatic oral cavity squamous cell carcinoma (OCSCC). MATERIALS AND METHODS We retrospectively retrieved 6,760 patients with OCSCC primarily treated surgery from surveillance, epidemiology, end results database between 2010 2015. They were randomly divided into training validation cohorts. Performance of the was...
The objectives of this study were to prospectively 1) explore the characteristics and enhanced patterns carotid body tumors (CBTs) at color Doppler ultrasound (CDU) contrast-enhanced ultrasonography (CEUS) qualitatively quantitatively 2) compare CDU CEUS for their morphology vascularity signature.CDU with Sonovue® used evaluate 25 CBT lesions. comparison between these ultrasonic modalities included size, Shamblin type, vascularity, feeding vessels lesion areas. time-intensity curve (TIC)...
Cervical aortic arch with aneurysm formation is considered an extremely rare condition. Here, we summarize our experience in treating 8 patients. We validated extra-anatomic ascending-to-infrarenal abdominal aorta bypass through the retroperitoneal cavity without circulatory arrest as alternative treatment for patients a tortuous that was unsuitable endovascular repair.From March 2015 to April 2018, (7 women; median age 46 years) diagnosed cervical complicated were treated at Peking Union...
Meeting abstracts Prognosis varies dramatically in head and neck squamous cell carcinoma (HNSCC) based on HPV status. In HPV+ patients, programmed death (PD)-1 expression has been linked to a better clinical outcome. We hypothesized that extent of PD-1 may differentially impact T
<div>Abstract<p>Improved understanding of expression immune checkpoint receptors (ICR) on tumor-infiltrating lymphocytes (TIL) may facilitate more effective immunotherapy in head and neck cancer (HNC) patients. A higher frequency PD-1<sup>+</sup> TIL has been reported human papillomavirus (HPV)<sup>+</sup> HNC patients, despite the role PD-1 T-cell exhaustion. This discordance led us to hypothesize that extent accurately defines function prognostic impact,...
<p>Supplementary Figure S1 shows identification of different subsets PD1+ cells</p>
<p>Supplementary Figure S1 shows identification of different subsets PD1+ cells</p>
<div>Abstract<p>Improved understanding of expression immune checkpoint receptors (ICR) on tumor-infiltrating lymphocytes (TIL) may facilitate more effective immunotherapy in head and neck cancer (HNC) patients. A higher frequency PD-1<sup>+</sup> TIL has been reported human papillomavirus (HPV)<sup>+</sup> HNC patients, despite the role PD-1 T-cell exhaustion. This discordance led us to hypothesize that extent accurately defines function prognostic impact,...
<p>For IL-10, Granzyme B and IFN-γ quantification, bulk TIL were stimulated in vitro with anti-CD3/CD28 beads protein transport inhibitor (BD GolgiPlugTM) for 6h.Cells then stained intracellular cytokine expression by flow cytometry. Summary data showing IL-10 MFI (P>0.05), percentage (p=0.0508), (P<0.01), LAP (P>0.05) Ki67 cytometry, gated on Tim-3- Tregs Tim-3+ from HNSCC TILs (n=4-11 patients per marker, as indicated).</p>