A5051498795- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Lung Cancer Research Studies
- Head and Neck Cancer Studies
- Immune Response and Inflammation
- Head and Neck Surgical Oncology
- Salivary Gland Tumors Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Mesenchymal stem cell research
- Colorectal and Anal Carcinomas
- Extracellular vesicles in disease
- Sinusitis and nasal conditions
- Ear and Head Tumors
- Inflammation biomarkers and pathways
- Lymphadenopathy Diagnosis and Analysis
- Lung Cancer Treatments and Mutations
- Cervical Cancer and HPV Research
- Breast Cancer Treatment Studies
- Adenosine and Purinergic Signaling
- Medical Practices and Rehabilitation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Economic and Financial Impacts of Cancer
Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde
2012-2024
Agaplesion Bethesda Krankenhaus
2024
University of Duisburg-Essen
2014-2023
Essen University Hospital
2012-2023
German Cancer Research Center
2021
Deutschen Konsortium für Translationale Krebsforschung
2021
University of Pittsburgh
2017-2018
UPMC Hillman Cancer Center
2015-2016
Data Harbor (United States)
2015
Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde
2015
Improved understanding of expression immune checkpoint receptors (ICR) on tumor-infiltrating lymphocytes (TIL) may facilitate more effective immunotherapy in head and neck cancer (HNC) patients. A higher frequency PD-1+ TIL has been reported human papillomavirus (HPV)+ HNC patients, despite the role PD-1 T-cell exhaustion. This discordance led us to hypothesize that extent accurately defines function prognostic impact, because PD-1high T cells be exhausted than PD-1low influence clinical...
Abstract Inhibitory immune-checkpoint receptors (ICRs), including programmed death 1 (PD-1), have been characterized as exhaustion markers on T cells that infiltrate the tumor microenvironment (TME) of many cancer types, head and neck (HNC). However, expression function ICRs, PD-1, natural killer (NK) remains less defined. NK are innate immune effector lyse epidermal growth factor receptor–overexpressing HNC via cetuximab-mediated antibody-dependent cytotoxicity. Cetuximab is clinically...
The incidence of human papillomavirus–positive (HPV+) head and neck squamous cell carcinoma (HNSCC) has surpassed that cervical cancer is projected to increase rapidly until 2060. coevolution HPV with transforming epithelial cells leads the shutdown host immune detection. Targeting proximal viral nucleic acid–sensing machinery an evolutionarily conserved strategy among viruses enable evasion. However, E7 from dominant subtype 16 in HNSCC shares low homology HPV18 E7, which was shown inhibit...
Abstract Purpose: The response rate of patients with head and neck squamous cell carcinoma (HNSCC) to cetuximab therapy is only 15% 20%, despite frequent EGFR overexpression. Because immunosuppression common in HNSCC, we hypothesized that adding a proinflammatory TLR8 agonist might result enhanced T-lymphocyte stimulation anti–EGFR-specific priming. Experimental Design: Fourteen previously untreated HNSCC were enrolled this neoadjuvant trial treated preoperatively 3 4 weekly doses motolimod...
Mesenchymal stromal cells (MSC) are an integral cellular component of the tumor microenvironment. Nevertheless, very little is known about MSC originating from human malignant tissue and modulation these by tumor-derived factors. The aim this study was to isolate characterize head neck squamous cell carcinoma (HNSCC) investigate their interaction with cells.MSC were isolated tissues HNSCC patients during routine oncological surgery. Immunophenotyping, immunofluorescence in vitro...
ABSTRACT The role of T cell receptor (TCR) signaling for adaptive immune responses is essential. ability to respond a broad spectrum tumor antigens requires an selection various TCR. So far, little known about the TCR richness and clonality in cellular response head neck cancer (HNC), though Endothelial Growth Factor Receptor (EGFR)-specific CD8+ can be enhanced by cetuximab therapy. Therefore, we investigated differences sequences between human papillomavirus (HPV)+ HPV− HNC patients, as...
Head and Neck Cancers (HNCs) have highly immunosuppressive properties. Small extracellular vesicles (sEVs), including exosomes, nanosized mediators of intercellular communication in the blood, carry proteins effectively inhibit anti-tumor immune responses HNCs. This study evaluates markers on sEVs from 40 HNC patients at different disease stages 3- 6-month follow-up after surgery and/or chemoradiotherapy. As controls, normal donors (NDs) are examined. Immunoregulatory surface were detected...
Meeting abstracts Co-inhibitory immune checkpoint receptors have become important targets for cancer immunotherapy. Programmed death 1 (PD-1) has been well-characterized on T cells in many types, including head and neck (HNC), its ability to mediate activation eventually
The role of neutrophils during cancer formation and elimination is diverse. Here, for the first time, we investigate neutrophil helper cells (NBH), their influence on B cell activity in regional lymph nodes (RLN) head-and-neck patients effect this neutrophil/B interaction patient prognosis. Circulating RLN with stage I–IV squamous carcinoma were investigated flow cytometry qPCR. In addition, co-localization RLNs was evaluated using immunohistochemistry. proliferation assessed correlated...
Abstract Patients with HPV − -localized head and neck cancer (HNC) show inferior outcomes after surgery radiochemotherapy compared to HPV-associated cancers. The underlying mechanisms remain elusive, but differences in immune status activity may be implicated. In this study, we analyzed profiles of CD8 + T cells myeloid-derived suppressor (MDSC) versus disease. overall frequency was reduced HNC healthy donors substantially increased curative therapy (surgery and/or radiochemotherapy)....
Cetuximab-based chemoimmunotherapy has been the standard of care for recurrent or metastatic squamous cell carcinoma head and neck (r/m SCCHN) more than a decade. To date, no predictive prognostic biomarkers have established to further guide systemic treatment with cetuximab-based in r/m SCCHN. Against this background, we retrospectively analyzed clinical blood-based parameters from 218 SCCHN patients treated including cetuximab. Multivariate Cox-regression models were used assess their...
Background: We investigated the expression patterns of cluster differentiation (CD) 44 and amphiregulin (AREG), two signaling molecules essential for cell proliferation differentiation, under influence selective tyrosine kinase inhibitors (TKIs) in human papillomavirus (HPV)<sup>+</sup> HPV<sup>−</sup> squamous carcinoma lines. Materials Methods: The protein CD44 AREG was determined by sandwich enzyme-linked immunosorbent assay lines UMSCC-11A UMSCC-14C, HPV<sup>+</sup> CERV-196 cells after...
Introduction Patients with HPV- localized head and neck cancer show distinct therapeutic responses compared to HPV-associated cancers, implicating differences in immune status response. Therefore, we analyzed profiles of myeloid-derived suppressor cells (MDSC) HPV+versus disease their influence on CD8+T cells.
Meeting abstracts T cell receptor (TCR) recognition of tumor antigen is essential for effective antitumor immunity. The immune system`s ability to respond a broad spectrum antigens requires sophisticated selection various TCR. So far, little known about the role TCR richness and
Zusammenfassung Hintergrund Schwannome sind seltene, benigne Tumore, die von den Gliazellen des peripheren Nervensystems (Schwannsche Zellen) ausgehen. Während es für intrakranielle Schwannome, insbesondere N. vestibularis, etablierte Therapiestrategien gibt, liegen zu extrakraniellen Schwannomen weniger belastbare Daten vor. Methode Es wurde eine retrospektive Analyse 20 Patienten mit histopathologisch gesicherten im Kopf-Hals-Bereich einem Schwerpunkt auf Tumorlokalisation und...