A5060599966- Lung Cancer Treatments and Mutations
- Cancer Diagnosis and Treatment
- Music Therapy and Health
- Asthma and respiratory diseases
- Head and Neck Cancer Studies
- Oral and Maxillofacial Pathology
- Anatomy and Medical Technology
- Psychosomatic Disorders and Their Treatments
- Vestibular and auditory disorders
- Cancer-related gene regulation
- Tumors and Oncological Cases
- Allergic Rhinitis and Sensitization
- HER2/EGFR in Cancer Research
- Ear and Head Tumors
- Nerve injury and regeneration
- Surgical Simulation and Training
- Respiratory and Cough-Related Research
- PI3K/AKT/mTOR signaling in cancer
- Soft tissue tumor case studies
- Sarcoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Obstructive Sleep Apnea Research
- Viral Infectious Diseases and Gene Expression in Insects
- Radiology practices and education
- Fibroblast Growth Factor Research
Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde
2021-2024
Heidelberg University
2015-2024
University Hospital Heidelberg
2015-2024
University Medical Centre Mannheim
2012-2024
Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde
2021-2024
Medizinische Fakultät Mannheim
2021-2024
Universitäts HNO Klinik Mannheim
2016-2023
Philipps University of Marburg
2023
University of Tübingen
1987-2022
Medical University of Vienna
2018
Although checkpoint inhibitors (CPI) have recently extended the treatment options and improved clinical response of advanced stage head neck squamous cell carcinoma (HNSCC), success remains unpredictable. Programmed death ligand‑1 (PD‑L1) is a key player in immunotherapy. Tumor cells, exosomes derived therefrom, are carriers PD‑L1 efficiently suppress immune responses. The aim present study was to analyze influence established therapies on expression HNSCC lines their exosomes. lines,...
Abstract Background After tracheostomy, the airway lacks an essential mechanism for warming and humidifying inspired air with consequent functional impairment discomfort. The purpose of this study was to compare hydration cold‐air nebulization versus heated high‐flow humidification on medical interventions tracheal ciliary beat frequency (CBF). Methods Newly tracheostomized patients (n = 20) were treated either or humidification. number required suctioning procedures clean trachea CBF...
Disease and therapy of head neck cancer impair quality life (QOL). QOL varies profoundly during follow-up.Aim: We sought to monitor nutritional status patients before, after (AT).Patients methods: This study evaluates by using the EORTC-questionnaires QLQ-C30 H&N35, body weight plasma albumin up two years AT.Results: Chemoradiotherapy is period most profound QOL-impairment. Postoperative almost reaches preoperative levels just before adjuvant does not differ significantly from pretherapeutic...
Purpose Ultrasound examinations are often criticized for having higher examiner dependency compared to other imaging techniques. Compared free-text reporting, structured reporting (SR) of head and neck sonography (HNS) achieves superior time efficiency as well report quality. However, there no findings concerning the influence SR on interrater reliability (IRR) HNS. Materials Methods Typical pathologies (n=4) in HNS were documented by video/images two certified ultrasound instructors....
Objectives: Obstructive sleep apnea (OSA) is a common disorder, which associated with recurrent oxygen desaturation during sleep. It has already been shown that nocturnal hypoxia may lead to cochlear dysfunction in patients OSA. Less known whether also impacts vestibular function those patients. Thus, the aim of presented study was assess potential vestibulotoxic effect nightly desaturations OSA by investigating possible correlation between respiratory parameters and tests. Methods: A total...
The validation of potential molecular targets in head and neck squamous cell carcinoma (SCC) is mandatory. β-Catenin E-cadherin are crucial for cancer progression through epithelial-mesenchymal transition. We analyzed the effect tyrosine kinase inhibitors nilotinib, dasatinib, erlotinib gefitinib on β-catenin expression SCC with respect to human papillomavirus (HPV) status.Expression lines UMSCC 11A, 14C CERV196 under influence were by enzyme-linked immunosorbent assay.All agents reduced...
Abstract Background An acute abdomen is an emergency that requires accurate diagnosis and prompt treatment. In pregnancy, the process even more challenging sometimes radiological findings are unclear. Moreover, endometriosis- related complications rare, especially in previously unknown endometriosis. Case presentation We report on a case of endometriosis-related sigmoid perforation during pregnancy (34 weeks gestation) due to deep intestinal infiltrating endometriosis with focal ulceration...
Digital twins derived from 3D scanning data were developed to measure soft tissue deformation in head and neck surgery by an artificial intelligence approach. This framework was applied suggesting feasibility of shift detection as a hitherto unsolved problem. In pig cadaver model 104 resection had been performed. The surface the removed (RTP) corresponding cavity (RC) scanned (N = 416) train (AI) with two different object detectors (HoloLens 2; ArtecEva). An (TS) created changing temperature...
Background/Aim: Therapeutic options of locally advanced or metastatic head and neck squamous cell carcinoma (HNSCC) are limited. Src cKIT key protein regulators for local tumor progression. The aim the study was to investigate therapeutic potential targeted therapies in human vitro. Therefore, influence selective tyrosine kinase inhibitors niotinib, dasatinib, erlotinib, gefitinib afatinib on expression Human papilloma virus (HPV)-positive HPV-negative cancer cells (SCC) analyzed Materials...
Background: The spatial gap between cochlear implants (CIs) and the auditory nerve limits frequency selectivity as large populations of spiral ganglion neurons (SGNs) are electrically stimulated synchronously. To improve CI performance, a possible strategy is to promote neurite outgrowth toward CI, thereby allowing discrete stimulation small SGN subpopulations. Brain-derived neurotrophic factor (BDNF) effective stimulate from SGNs. Method: TrkB (tropomyosin receptor kinase B) agonists, BDNF,...
Lung cancer rarely metastasizes to the palatine tonsil. There have only been a few cases that reported on tonsillar metastases of pulmonary adenocarcinoma. In majority these primary diagnosis is small cell lung cancer. The present case report resents an unusual 66-year-old woman with multiple metastasized adenocarcinoma, which was finally detected by tonsillectomy. and review literature revealed importance complete systematic tumor staging, including examination oral cavity in evident...
The results of surgical repair extensive muscle tissue defects are still primary concern, leaving patients with residual cosmetic and functional impairments. Therefore, skeletal engineering attempts to grow neo‑tissue from human stem cells promote regeneration support defect closure. Despite intensive research efforts, the goal stable induction myogenic differentiation in expanded by using clinically feasible stimuli, has not yet been reached a sufficient extent. present study investigated...
Patients with head and neck squamous cell carcinoma (HNSCC) are at risk for local regional relapse, as well occurrence of synchronous or metachronous secondary carcinoma. The aim this retrospective study was to evaluate the frequency malignancies amongst HNSCC patients their association age, sex TNM classification, smoking alcohol abuse. Data from 394 who were treated Department Otorhinolaryngology‑Head Neck Surgery University Hospital Mannheim between 2011 2015 retrieved analyzed using...
Background: Despite extensive research into new treatment options, the prognosis for head and neck squamous cell carcinoma remains poor. Platelet-derived growth factor (PDGF) is up-regulated in HNSCC expression levels decrease after surgery, suggesting its role tumour development. The influence of HPV on PDGF/PDGF receptor (PDGFR) pathway unclear. In this study, we investigated effect small-molecule tyrosine kinase inhibitors (TKIs) PDGF vitro using cancer lines with different human...
Augmented Reality can improve surgical planning and performance in parotid surgery. For easier application we implemented a voice control manual for our augmented reality system. The aim of the study was to evaluate feasibility real-life situations.We used HoloLens 1® (Microsoft Corporation) with special speech recognition software evaluation took place audiometry cubicle during real procedures. Voice commands were display various 3D structures patient 1®. Commands had different variations...
The identification of molecular targets in the therapy human papilloma virus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) is a primary aim cancer research. Matrix metalloproteinase 9 (MMP-9) vascular endothelial growth factor receptor (VEGFR) have important roles development HNSCC. tyrosine kinase inhibitors, nilotinib, dasatinib, erlotinib gefitinib are well established targeted tumors other than present study aimed to investigate alteration MMP-9 VEGFR-1 expression...